CYC4_PSEST
ID CYC4_PSEST Reviewed; 210 AA.
AC Q52369;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Cytochrome c4;
DE Flags: Precursor;
GN Name=cc4;
OS Pseudomonas stutzeri (Pseudomonas perfectomarina).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=316;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 11607 / DSM 50227 / LMG 1228 / NCIMB 9721 / NCTC 10475;
RX PubMed=8026750; DOI=10.1016/0378-1119(94)90219-4;
RA Christensen H.E.M.;
RT "Cloning and characterisation of the gene encoding cytochrome c4 from
RT Pseudomonas stutzeri.";
RL Gene 144:139-140(1994).
RN [2]
RP X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS).
RC STRAIN=ATCC 11607 / DSM 50227 / LMG 1228 / NCIMB 9721 / NCTC 10475;
RX PubMed=9032080; DOI=10.1016/s0969-2126(97)00179-2;
RA Kadziola A., Larsen S.;
RT "Crystal structure of the dihaem cytochrome c4 from Pseudomonas stutzeri
RT determined at 2.2-A resolution.";
RL Structure 5:203-216(1997).
CC -!- FUNCTION: Diheme, high potential cytochrome c believed to be an
CC intermediate electron donor to terminal oxidation systems.
CC -!- SUBCELLULAR LOCATION: Periplasm.
CC -!- PTM: Binds 2 heme c groups covalently per subunit.
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DR EMBL; U05988; AAA20247.1; -; Genomic_DNA.
DR RefSeq; WP_014818660.1; NZ_PJJZ01000003.1.
DR PDB; 1ETP; X-ray; 2.20 A; A/B=21-210.
DR PDB; 1M6Z; X-ray; 1.35 A; A/B/C/D=21-210.
DR PDB; 1M70; X-ray; 1.25 A; A/B/C/D=21-210.
DR PDBsum; 1ETP; -.
DR PDBsum; 1M6Z; -.
DR PDBsum; 1M70; -.
DR AlphaFoldDB; Q52369; -.
DR SMR; Q52369; -.
DR STRING; 32042.PstZobell_09982; -.
DR DrugBank; DB03317; Ferroheme C.
DR EvolutionaryTrace; Q52369; -.
DR GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR GO; GO:0009055; F:electron transfer activity; IEA:InterPro.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR Gene3D; 1.10.760.10; -; 2.
DR InterPro; IPR009056; Cyt_c-like_dom.
DR InterPro; IPR036909; Cyt_c-like_dom_sf.
DR InterPro; IPR024167; Cytochrome_c4-like.
DR Pfam; PF00034; Cytochrom_C; 2.
DR PIRSF; PIRSF000005; Cytochrome_c4; 1.
DR SUPFAM; SSF46626; SSF46626; 2.
DR PROSITE; PS51007; CYTC; 2.
PE 1: Evidence at protein level;
KW 3D-structure; Electron transport; Heme; Iron; Metal-binding; Periplasm;
KW Signal; Transport.
FT SIGNAL 1..20
FT CHAIN 21..210
FT /note="Cytochrome c4"
FT /id="PRO_0000006509"
FT BINDING 34
FT /ligand="heme c"
FT /ligand_id="ChEBI:CHEBI:61717"
FT /ligand_label="1"
FT /note="covalent"
FT BINDING 37
FT /ligand="heme c"
FT /ligand_id="ChEBI:CHEBI:61717"
FT /ligand_label="1"
FT /note="covalent"
FT BINDING 38
FT /ligand="heme c"
FT /ligand_id="ChEBI:CHEBI:61717"
FT /ligand_label="1"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="axial binding residue"
FT BINDING 86
FT /ligand="heme c"
FT /ligand_id="ChEBI:CHEBI:61717"
FT /ligand_label="1"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="axial binding residue"
FT BINDING 139
FT /ligand="heme c"
FT /ligand_id="ChEBI:CHEBI:61717"
FT /ligand_label="2"
FT /note="covalent"
FT BINDING 142
FT /ligand="heme c"
FT /ligand_id="ChEBI:CHEBI:61717"
FT /ligand_label="2"
FT /note="covalent"
FT BINDING 143
FT /ligand="heme c"
FT /ligand_id="ChEBI:CHEBI:61717"
FT /ligand_label="2"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="axial binding residue"
FT BINDING 187
FT /ligand="heme c"
FT /ligand_id="ChEBI:CHEBI:61717"
FT /ligand_label="2"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="axial binding residue"
FT HELIX 24..28
FT /evidence="ECO:0007829|PDB:1M70"
FT HELIX 32..34
FT /evidence="ECO:0007829|PDB:1M70"
FT HELIX 35..38
FT /evidence="ECO:0007829|PDB:1M70"
FT HELIX 57..71
FT /evidence="ECO:0007829|PDB:1M70"
FT HELIX 84..86
FT /evidence="ECO:0007829|PDB:1M70"
FT TURN 87..92
FT /evidence="ECO:0007829|PDB:1M70"
FT HELIX 95..107
FT /evidence="ECO:0007829|PDB:1M70"
FT HELIX 117..129
FT /evidence="ECO:0007829|PDB:1M70"
FT HELIX 132..134
FT /evidence="ECO:0007829|PDB:1M70"
FT HELIX 140..143
FT /evidence="ECO:0007829|PDB:1M70"
FT HELIX 151..153
FT /evidence="ECO:0007829|PDB:1M70"
FT HELIX 163..174
FT /evidence="ECO:0007829|PDB:1M70"
FT TURN 180..184
FT /evidence="ECO:0007829|PDB:1M70"
FT HELIX 186..191
FT /evidence="ECO:0007829|PDB:1M70"
FT HELIX 196..207
FT /evidence="ECO:0007829|PDB:1M70"
SQ SEQUENCE 210 AA; 21742 MW; C33CF23A6FAA6F99 CRC64;
MNKVLVSLLL TLGITGMAHA AGDAEAGQGK VAVCGACHGV DGNSPAPNFP KLAGQGERYL
LKQLQDIKAG STPGAPEGVG RKVLEMTGML DPLSDQDLED IAAYFSSQKG SVGYADPALA
KQGEKLFRGG KLDQGMPACT GCHAPNGVGN DLAGFPKLGG QHAAYTAKQL TDFREGNRTN
DGDTMIMRGV AAKLSNKDIE ALSSYIQGLH
