CYCH_RHIME
ID CYCH_RHIME Reviewed; 381 AA.
AC P45400;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 30-MAY-2000, sequence version 2.
DT 25-MAY-2022, entry version 116.
DE RecName: Full=Cytochrome c-type biogenesis protein CycH;
GN Name=cycH; OrderedLocusNames=R01017; ORFNames=SMc02361;
OS Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium
OS meliloti).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC Rhizobiaceae; Sinorhizobium/Ensifer group; Sinorhizobium.
OX NCBI_TaxID=266834;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=AK631;
RX PubMed=7715602; DOI=10.1007/bf00425819;
RA Kereszt A., Slaska-Kiss K., Putnoky P., Banfalvi Z., Kondorosi A.;
RT "The cycHJKL genes of Rhizobium meliloti involved in cytochrome c
RT biogenesis are required for 'respiratory' nitrate reduction ex planta and
RT for nitrogen fixation during symbiosis.";
RL Mol. Gen. Genet. 247:39-47(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1021;
RX PubMed=11481430; DOI=10.1073/pnas.161294398;
RA Capela D., Barloy-Hubler F., Gouzy J., Bothe G., Ampe F., Batut J.,
RA Boistard P., Becker A., Boutry M., Cadieu E., Dreano S., Gloux S.,
RA Godrie T., Goffeau A., Kahn D., Kiss E., Lelaure V., Masuy D., Pohl T.,
RA Portetelle D., Puehler A., Purnelle B., Ramsperger U., Renard C.,
RA Thebault P., Vandenbol M., Weidner S., Galibert F.;
RT "Analysis of the chromosome sequence of the legume symbiont Sinorhizobium
RT meliloti strain 1021.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:9877-9882(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1021;
RX PubMed=11474104; DOI=10.1126/science.1060966;
RA Galibert F., Finan T.M., Long S.R., Puehler A., Abola P., Ampe F.,
RA Barloy-Hubler F., Barnett M.J., Becker A., Boistard P., Bothe G.,
RA Boutry M., Bowser L., Buhrmester J., Cadieu E., Capela D., Chain P.,
RA Cowie A., Davis R.W., Dreano S., Federspiel N.A., Fisher R.F., Gloux S.,
RA Godrie T., Goffeau A., Golding B., Gouzy J., Gurjal M., Hernandez-Lucas I.,
RA Hong A., Huizar L., Hyman R.W., Jones T., Kahn D., Kahn M.L., Kalman S.,
RA Keating D.H., Kiss E., Komp C., Lelaure V., Masuy D., Palm C., Peck M.C.,
RA Pohl T.M., Portetelle D., Purnelle B., Ramsperger U., Surzycki R.,
RA Thebault P., Vandenbol M., Vorhoelter F.J., Weidner S., Wells D.H.,
RA Wong K., Yeh K.-C., Batut J.;
RT "The composite genome of the legume symbiont Sinorhizobium meliloti.";
RL Science 293:668-672(2001).
CC -!- FUNCTION: Required for the biogenesis of c-type cytochromes. Possible
CC subunit of a heme lyase.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC membrane protein {ECO:0000305}; Periplasmic side {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the CycH family. {ECO:0000305}.
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DR EMBL; X82560; CAA57904.1; -; Genomic_DNA.
DR EMBL; AL591688; CAC45589.1; -; Genomic_DNA.
DR PIR; S54748; S49614.
DR RefSeq; NP_385123.1; NC_003047.1.
DR RefSeq; WP_010968988.1; NC_003047.1.
DR AlphaFoldDB; P45400; -.
DR SMR; P45400; -.
DR STRING; 266834.SMc02361; -.
DR EnsemblBacteria; CAC45589; CAC45589; SMc02361.
DR GeneID; 61602482; -.
DR KEGG; sme:SMc02361; -.
DR PATRIC; fig|266834.11.peg.2421; -.
DR eggNOG; COG4235; Bacteria.
DR HOGENOM; CLU_036074_4_1_5; -.
DR OMA; IMQQMIG; -.
DR Proteomes; UP000001976; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0017004; P:cytochrome complex assembly; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.10; -; 2.
DR InterPro; IPR017560; Cyt_c_biogenesis_CcmI.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR SUPFAM; SSF48452; SSF48452; 1.
DR TIGRFAMs; TIGR03142; cytochro_ccmI; 1.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Cytochrome c-type biogenesis; Membrane;
KW Reference proteome; Repeat; TPR repeat; Transmembrane; Transmembrane helix.
FT CHAIN 1..381
FT /note="Cytochrome c-type biogenesis protein CycH"
FT /id="PRO_0000201574"
FT TRANSMEM 2..22
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 95..115
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 116..381
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT REPEAT 154..187
FT /note="TPR 1"
FT REPEAT 191..224
FT /note="TPR 2"
FT REPEAT 226..258
FT /note="TPR 3"
FT REPEAT 325..358
FT /note="TPR 4"
FT CONFLICT 74
FT /note="S -> A (in Ref. 1; CAA57904)"
FT /evidence="ECO:0000305"
FT CONFLICT 226
FT /note="R -> P (in Ref. 1; CAA57904)"
FT /evidence="ECO:0000305"
FT CONFLICT 240
FT /note="K -> R (in Ref. 1; CAA57904)"
FT /evidence="ECO:0000305"
FT CONFLICT 271..272
FT /note="EL -> DV (in Ref. 1; CAA57904)"
FT /evidence="ECO:0000305"
FT CONFLICT 280..281
FT /note="Missing (in Ref. 1)"
FT /evidence="ECO:0000305"
FT CONFLICT 286
FT /note="D -> N (in Ref. 1; CAA57904)"
FT /evidence="ECO:0000305"
FT CONFLICT 329
FT /note="M -> I (in Ref. 1; CAA57904)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 381 AA; 40321 MW; DFFB39391554033E CRC64;
MLFWILVAIL TAAVAAVLLL PLMRAAEPLP SRHSHDIEVY RDQLGELARD REAGLIGSEE
AELARAEIAR RMLSASAADQ AVAERTPKRL LSNRLAQAFI FLCLPAVGLC LYLTTGSPGV
PAQPLAARLA DPGDDVNILI AKAENHLALN PQDGAGWDLL APIYMRHGRL DDAVAAYDRA
IRLLGPTPAR MGGYAEALVA QAGGLVTAEA QNALQKALAL DPDDPRSAFY LALGLKQEGK
HAEALAAFRK LAESSPADAP WLSLVNQHIA ELAAAPAGPG PAAPGDPAPG DIAAAKEMNA
GDRQAMIRGM VDSLASRLKE DPANLEGWMR LVRSYVVLDQ RDRAKDALHD GLRAFPATGE
QGKQLLALAR ELGIDAGGEA E
