CYCLD_ANTMA
ID CYCLD_ANTMA Reviewed; 286 AA.
AC O49250; Q6Y9Y4; Q7XJF0; Q9LLF4;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1998, sequence version 1.
DT 25-MAY-2022, entry version 58.
DE RecName: Full=Transcription factor CYCLOIDEA;
GN Name=CYC;
OS Antirrhinum majus (Garden snapdragon).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Lamiales; Plantaginaceae; Antirrhineae; Antirrhinum.
OX NCBI_TaxID=4151;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND DEVELOPMENTAL STAGE.
RX PubMed=8893002; DOI=10.1038/383794a0;
RA Luo D., Carpenter R., Vincent C., Copsey L., Coen E.;
RT "Origin of floral asymmetry in Antirrhinum.";
RL Nature 383:794-799(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 22-270.
RX PubMed=12832647; DOI=10.1093/molbev/msg166;
RA Guebitz T., Caldwell A., Hudson A.;
RT "Rapid molecular evolution of CYCLOIDEA-like genes in Antirrhinum and its
RT relatives.";
RL Mol. Biol. Evol. 20:1537-1544(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 94-209.
RX PubMed=12885953; DOI=10.1093/molbev/msg211;
RA Reeves P.A., Olmstead R.G.;
RT "Evolution of the TCP gene family in Asteridae: cladistic and network
RT approaches to understanding regulatory gene family diversification and its
RT impact on morphological evolution.";
RL Mol. Biol. Evol. 20:1997-2009(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 121-284.
RX DOI=10.1006/anbo.2000.1178;
RA Citerne H., Moeller M., Cronk Q.C.B.;
RT "Diversity of cycloidea-like genes in Gesneriaceae in relation to floral
RT symmetry.";
RL Ann. Bot. 86:167-176(2000).
RN [5]
RP DNA-BINDING, AND FUNCTION.
RX PubMed=16236768; DOI=10.1242/dev.02085;
RA Costa M.M., Fox S., Hanna A.I., Baxter C., Coen E.;
RT "Evolution of regulatory interactions controlling floral asymmetry.";
RL Development 132:5093-5101(2005).
CC -!- FUNCTION: Involved in the dorsovental asymmetry of flowers. Retards
CC growth rate and reduces organ number in the dorsal region of flowers.
CC Binds specifically to the DNA sequence 5'-GGNCCCNC-3', and is able to
CC bind to the RAD promoter sequence in vivo.
CC {ECO:0000269|PubMed:16236768, ECO:0000269|PubMed:8893002}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00701}.
CC -!- DEVELOPMENTAL STAGE: First observed in a dorsal domain of floral
CC meristems, prior to any morphological dorsoventral asymmetry. Later
CC expressed in dorsal organ primordia. {ECO:0000269|PubMed:8893002}.
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DR EMBL; Y16313; CAA76176.1; -; mRNA.
DR EMBL; AY316729; AAP84126.1; -; Genomic_DNA.
DR EMBL; AY168141; AAO45702.1; -; Genomic_DNA.
DR EMBL; AF208341; AAF78184.1; -; Genomic_DNA.
DR PIR; T17028; T17028.
DR AlphaFoldDB; O49250; -.
DR SMR; O49250; -.
DR GO; GO:0005634; C:nucleus; NAS:UniProtKB.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; NAS:UniProtKB.
DR GO; GO:0048262; P:determination of dorsal/ventral asymmetry; IMP:UniProtKB.
DR GO; GO:0009908; P:flower development; IMP:UniProtKB.
DR GO; GO:0009799; P:specification of symmetry; IMP:UniProtKB.
DR InterPro; IPR017888; CYC/TB1_R_domain.
DR InterPro; IPR017887; TF_TCP_subgr.
DR InterPro; IPR005333; Transcription_factor_TCP.
DR PANTHER; PTHR31072; PTHR31072; 1.
DR Pfam; PF03634; TCP; 1.
DR PROSITE; PS51370; R; 1.
DR PROSITE; PS51369; TCP; 1.
PE 1: Evidence at protein level;
KW Developmental protein; DNA-binding; Nucleus; Transcription;
KW Transcription regulation.
FT CHAIN 1..286
FT /note="Transcription factor CYCLOIDEA"
FT /id="PRO_0000330800"
FT DOMAIN 87..145
FT /note="TCP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00701"
FT DOMAIN 200..217
FT /note="R"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00702"
FT REGION 72..100
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 193..213
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 84..100
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 142
FT /note="I -> V (in Ref. 4; AAF78184)"
FT /evidence="ECO:0000305"
FT CONFLICT 169
FT /note="D -> E (in Ref. 3; AAO45702 and 4; AAF78184)"
FT /evidence="ECO:0000305"
FT CONFLICT 258
FT /note="A -> T (in Ref. 4; AAF78184)"
FT /evidence="ECO:0000305"
FT CONFLICT 268..269
FT /note="LS -> FA (in Ref. 2; AAP84126 and 4; AAF78184)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 286 AA; 32137 MW; 0EF39C651426586D CRC64;
MFGKNTYLHL PQVSSSLHSR AATSVVDLNG NEIQLHDMLS GHYLTTANAP VLESTALFNN
NNNFNHDVVN GLNRDPSPTF PTKQAVKKDR HSKIYTSQGP RDRRVRLSIG IARKFFDLQE
MLGFDKPSKT LDWLLTKSKT AIKELVQSKS TKSNSSSPCD DCEEVVSVDS ENVTDHSKGK
SLKANNKCKE AMDSHQAAAK ESRAKARARA RERTKEKMCI KQLNEAIVLR NHQFEVSGTR
EAFVHPVFGF HQQNYGNASH ENWDQSNLSS QSNQLCAILN QHKFIN