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CYCLD_ANTMA
ID   CYCLD_ANTMA             Reviewed;         286 AA.
AC   O49250; Q6Y9Y4; Q7XJF0; Q9LLF4;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   25-MAY-2022, entry version 58.
DE   RecName: Full=Transcription factor CYCLOIDEA;
GN   Name=CYC;
OS   Antirrhinum majus (Garden snapdragon).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Lamiales; Plantaginaceae; Antirrhineae; Antirrhinum.
OX   NCBI_TaxID=4151;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND DEVELOPMENTAL STAGE.
RX   PubMed=8893002; DOI=10.1038/383794a0;
RA   Luo D., Carpenter R., Vincent C., Copsey L., Coen E.;
RT   "Origin of floral asymmetry in Antirrhinum.";
RL   Nature 383:794-799(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 22-270.
RX   PubMed=12832647; DOI=10.1093/molbev/msg166;
RA   Guebitz T., Caldwell A., Hudson A.;
RT   "Rapid molecular evolution of CYCLOIDEA-like genes in Antirrhinum and its
RT   relatives.";
RL   Mol. Biol. Evol. 20:1537-1544(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 94-209.
RX   PubMed=12885953; DOI=10.1093/molbev/msg211;
RA   Reeves P.A., Olmstead R.G.;
RT   "Evolution of the TCP gene family in Asteridae: cladistic and network
RT   approaches to understanding regulatory gene family diversification and its
RT   impact on morphological evolution.";
RL   Mol. Biol. Evol. 20:1997-2009(2003).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 121-284.
RX   DOI=10.1006/anbo.2000.1178;
RA   Citerne H., Moeller M., Cronk Q.C.B.;
RT   "Diversity of cycloidea-like genes in Gesneriaceae in relation to floral
RT   symmetry.";
RL   Ann. Bot. 86:167-176(2000).
RN   [5]
RP   DNA-BINDING, AND FUNCTION.
RX   PubMed=16236768; DOI=10.1242/dev.02085;
RA   Costa M.M., Fox S., Hanna A.I., Baxter C., Coen E.;
RT   "Evolution of regulatory interactions controlling floral asymmetry.";
RL   Development 132:5093-5101(2005).
CC   -!- FUNCTION: Involved in the dorsovental asymmetry of flowers. Retards
CC       growth rate and reduces organ number in the dorsal region of flowers.
CC       Binds specifically to the DNA sequence 5'-GGNCCCNC-3', and is able to
CC       bind to the RAD promoter sequence in vivo.
CC       {ECO:0000269|PubMed:16236768, ECO:0000269|PubMed:8893002}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00701}.
CC   -!- DEVELOPMENTAL STAGE: First observed in a dorsal domain of floral
CC       meristems, prior to any morphological dorsoventral asymmetry. Later
CC       expressed in dorsal organ primordia. {ECO:0000269|PubMed:8893002}.
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DR   EMBL; Y16313; CAA76176.1; -; mRNA.
DR   EMBL; AY316729; AAP84126.1; -; Genomic_DNA.
DR   EMBL; AY168141; AAO45702.1; -; Genomic_DNA.
DR   EMBL; AF208341; AAF78184.1; -; Genomic_DNA.
DR   PIR; T17028; T17028.
DR   AlphaFoldDB; O49250; -.
DR   SMR; O49250; -.
DR   GO; GO:0005634; C:nucleus; NAS:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; NAS:UniProtKB.
DR   GO; GO:0048262; P:determination of dorsal/ventral asymmetry; IMP:UniProtKB.
DR   GO; GO:0009908; P:flower development; IMP:UniProtKB.
DR   GO; GO:0009799; P:specification of symmetry; IMP:UniProtKB.
DR   InterPro; IPR017888; CYC/TB1_R_domain.
DR   InterPro; IPR017887; TF_TCP_subgr.
DR   InterPro; IPR005333; Transcription_factor_TCP.
DR   PANTHER; PTHR31072; PTHR31072; 1.
DR   Pfam; PF03634; TCP; 1.
DR   PROSITE; PS51370; R; 1.
DR   PROSITE; PS51369; TCP; 1.
PE   1: Evidence at protein level;
KW   Developmental protein; DNA-binding; Nucleus; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..286
FT                   /note="Transcription factor CYCLOIDEA"
FT                   /id="PRO_0000330800"
FT   DOMAIN          87..145
FT                   /note="TCP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00701"
FT   DOMAIN          200..217
FT                   /note="R"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00702"
FT   REGION          72..100
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          193..213
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        84..100
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        142
FT                   /note="I -> V (in Ref. 4; AAF78184)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        169
FT                   /note="D -> E (in Ref. 3; AAO45702 and 4; AAF78184)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        258
FT                   /note="A -> T (in Ref. 4; AAF78184)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        268..269
FT                   /note="LS -> FA (in Ref. 2; AAP84126 and 4; AAF78184)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   286 AA;  32137 MW;  0EF39C651426586D CRC64;
     MFGKNTYLHL PQVSSSLHSR AATSVVDLNG NEIQLHDMLS GHYLTTANAP VLESTALFNN
     NNNFNHDVVN GLNRDPSPTF PTKQAVKKDR HSKIYTSQGP RDRRVRLSIG IARKFFDLQE
     MLGFDKPSKT LDWLLTKSKT AIKELVQSKS TKSNSSSPCD DCEEVVSVDS ENVTDHSKGK
     SLKANNKCKE AMDSHQAAAK ESRAKARARA RERTKEKMCI KQLNEAIVLR NHQFEVSGTR
     EAFVHPVFGF HQQNYGNASH ENWDQSNLSS QSNQLCAILN QHKFIN
 
 
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