ID   CYCLE_ANNCH             Reviewed;           6 AA.
AC   P85003;
DT   17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   17-OCT-2006, sequence version 1.
DT   11-DEC-2019, entry version 12.
DE   RecName: Full=Cyclopeptide E;
OS   Annona cherimola (Custard apple) (Cherimoya).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Magnoliidae; Magnoliales; Annonaceae;
OC   Annonoideae; Annoneae; Annona.
OX   NCBI_TaxID=49314;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, CROSS-LINK, FUNCTION, AND MASS SPECTROMETRY.
RC   TISSUE=Seed {ECO:0000269|PubMed:16040066};
RX   PubMed=16040066; DOI=10.1016/j.phytochem.2005.06.011;
RA   Wele A., Zhang Y., Brouard J.-P., Pousset J.-L., Bodo B.;
RT   "Two cyclopeptides from the seeds of Annona cherimola.";
RL   Phytochemistry 66:2376-2380(2005).
CC   -!- FUNCTION: Probably participates in a plant defense mechanism. Has
CC       cytotoxic activity against human nasopharyngeal carcinoma with an
CC       IC(50) of 17 nM. {ECO:0000269|PubMed:16040066}.
CC   -!- PTM: This is a cyclic peptide. {ECO:0000269|PubMed:16040066}.
CC   -!- MASS SPECTROMETRY: Mass=635; Method=Electrospray;
CC       Evidence={ECO:0000269|PubMed:16040066};
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DR   GO; GO:0006952; P:defense response; IDA:UniProtKB.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Plant defense.
FT   PEPTIDE         1..6
FT                   /note="Cyclopeptide E"
FT                   /evidence="ECO:0000269|PubMed:16040066"
FT                   /id="PRO_0000253927"
FT   CROSSLNK        1..6
FT                   /note="Cyclopeptide (Pro-Tyr)"
SQ   SEQUENCE   6 AA;  653 MW;  7B59C87728670000 CRC64;
     PGLGFY