ID   CYCL_WDSV               Reviewed;         297 AA.
AC   Q88939;
DT   21-SEP-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   23-FEB-2022, entry version 70.
DE   RecName: Full=Retroviral cyclin;
DE            Short=Rv-cyclin;
DE   AltName: Full=ORF-A protein;
GN   Name=orfA;
OS   Walleye dermal sarcoma virus (WDSV).
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Ortervirales; Retroviridae; Orthoretrovirinae; Epsilonretrovirus.
OX   NCBI_TaxID=39720;
OH   NCBI_TaxID=283036; Sander vitreus (Walleye) (Perca vitrea).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=7636975; DOI=10.1128/jvi.69.9.5320-5331.1995;
RA   Holzschu D.L., Martineau D., Fodor S.K., Vogt V.M., Bowser P.R.,
RA   Casey J.W.;
RT   "Nucleotide sequence and protein analysis of a complex piscine retrovirus,
RT   walleye dermal sarcoma virus.";
RL   J. Virol. 69:5320-5331(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=NY 2003;
RX   PubMed=17698670; DOI=10.1099/vir.0.82967-0;
RA   Rovnak J., Casey R.N., Brewster C.D., Casey J.W., Quackenbush S.L.;
RT   "Establishment of productively infected walleye dermal sarcoma explant
RT   cells.";
RL   J. Gen. Virol. 88:2583-2589(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RA   Chappey C.;
RL   Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=11162816; DOI=10.1006/viro.2000.0731;
RA   Rovnak J., Casey J.W., Quackenbush S.L.;
RT   "Intracellular targeting of walleye dermal sarcoma virus Orf A (rv-
RT   cyclin).";
RL   Virology 280:31-40(2001).
RN   [5]
RP   FUNCTION, AND INTERACTION WITH WALLEYE TAF9.
RX   PubMed=17035330; DOI=10.1128/jvi.01425-06;
RA   Rovnak J., Quackenbush S.L.;
RT   "Walleye dermal sarcoma virus retroviral cyclin directly contacts TAF9.";
RL   J. Virol. 80:12041-12048(2006).
RN   [6]
RP   FUNCTION.
RX   PubMed=19176230; DOI=10.1016/j.virol.2008.12.026;
RA   Quackenbush S.L., Linton A., Brewster C.D., Rovnak J.;
RT   "Walleye dermal sarcoma virus rv-cyclin inhibits NF-kappaB-dependent
RT   transcription.";
RL   Virology 386:55-60(2009).
RN   [7]
RP   INTERACTION WITH HUMAN CDK3 AND CDK8.
RX   PubMed=21067790; DOI=10.1016/j.virol.2010.10.022;
RA   Brewster C.D., Birkenheuer C.H., Vogt M.B., Quackenbush S.L., Rovnak J.;
RT   "The retroviral cyclin of walleye dermal sarcoma virus binds cyclin-
RT   dependent kinases 3 and 8.";
RL   Virology 409:299-307(2011).
CC   -!- FUNCTION: Transforming protein which induces the development of dermal
CC       sarcomas. Induces positive and negative regulation of transcription
CC       from host and viral promoters by interacting with various cellular
CC       factors involved in protein transcription regulation.
CC       {ECO:0000269|PubMed:11162816, ECO:0000269|PubMed:17035330,
CC       ECO:0000269|PubMed:19176230}.
CC   -!- SUBUNIT: Interacts (via transcription activation domain) with host TAF9
CC       in vitro. Interacts with host CDK3 and CDK8.
CC       {ECO:0000269|PubMed:17035330, ECO:0000269|PubMed:21067790}.
CC   -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000269|PubMed:11162816}.
CC       Note=Concentrated in interchromatin granule clusters and perichromatin
CC       fibrils.
CC   -!- DOMAIN: Contains two known functional domains, a cyclin box motif and a
CC       carboxy terminal transcription activation domain.
CC   -!- SIMILARITY: Belongs to the cyclin family. {ECO:0000305}.
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DR   EMBL; L41838; AAA99528.1; -; Genomic_RNA.
DR   EMBL; EF428979; ABO25844.1; -; Genomic_DNA.
DR   EMBL; AF033822; AAC82609.1; -; Genomic_RNA.
DR   PIR; T09396; T09396.
DR   RefSeq; NP_045940.1; NC_001867.1.
DR   SMR; Q88939; -.
DR   GeneID; 1403500; -.
DR   KEGG; vg:1403500; -.
DR   Proteomes; UP000007081; Genome.
DR   Proteomes; UP000008337; Genome.
DR   Proteomes; UP000156462; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0060153; P:modulation by virus of host cell cycle; IEA:UniProtKB-KW.
DR   InterPro; IPR036915; Cyclin-like_sf.
DR   InterPro; IPR012167; Cyclin_epsilonretrovir.
DR   InterPro; IPR006671; Cyclin_N.
DR   Pfam; PF00134; Cyclin_N; 1.
DR   PIRSF; PIRSF015200; Cyclin_WDSV; 1.
DR   SUPFAM; SSF47954; SSF47954; 1.
PE   1: Evidence at protein level;
KW   Activator; Coiled coil; Cyclin; Host nucleus; Host-virus interaction;
KW   Modulation of host cell cycle by viral cyclin-like protein;
KW   Modulation of host cell cycle by virus; Oncogene; Reference proteome;
KW   Repressor.
FT   CHAIN           1..297
FT                   /note="Retroviral cyclin"
FT                   /id="PRO_0000412274"
FT   DOMAIN          21..113
FT                   /note="Cyclin N-terminal"
FT   REGION          21..113
FT                   /note="Transcription activation domain"
FT   COILED          222..270
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   297 AA;  33071 MW;  7359364F198F2802 CRC64;
     MDIPVEFLTA QEPLSYGHIP PVYWKELLNW IDRILTHNQA TPNTWEATHM VLLKLHGTLS
     FSNPAQLPLV AAACLQIAAK HTEAHSRLAD PDYITMLGDG VYTKPSLLLT ETMALFIVGG
     HVGAYTLAAC DWLLGSLPFS QAENDLLHPY MYHYIKLSYR HRTPDYHSSP ALRAAVVIAA
     AVKGADLLEM NMLFIMMYHL THISTASLSL GLTHFTAALQ RQINLDFAEA EQREAAERRA
     LLEREREQQL QEARERLDDV MAVLEAEVAI TITTATEGTD AEDTSEVDVI NVVDPIG