ID   CYC_ALLPO               Reviewed;         111 AA.
AC   P00064;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Cytochrome c;
OS   Allium porrum (Leek) (Allium ampeloprasum var. porrum).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Asparagales; Amaryllidaceae;
OC   Allioideae; Allieae; Allium.
OX   NCBI_TaxID=4681;
RN   [1]
RP   PROTEIN SEQUENCE, ACETYLATION AT ALA-1, HYDROXYLATION AT PRO-79, AND
RP   METHYLATION AT LYS-80 AND LYS-94.
RX   PubMed=4352905; DOI=10.1042/bj1310247;
RA   Brown R.H., Boulter D.;
RT   "The amino acid sequence of cytochrome c from Allium porrum L. (leek).";
RL   Biochem. J. 131:247-251(1973).
CC   -!- FUNCTION: Electron carrier protein. The oxidized form of the cytochrome
CC       c heme group can accept an electron from the heme group of the
CC       cytochrome c1 subunit of cytochrome reductase. Cytochrome c then
CC       transfers this electron to the cytochrome oxidase complex, the final
CC       protein carrier in the mitochondrial electron-transport chain.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion intermembrane space. Note=Loosely
CC       associated with the inner membrane.
CC   -!- PTM: Binds 1 heme c group covalently per subunit.
CC   -!- PTM: It is not sure whether methylation is on Lys-80 or Lys-81.
CC       {ECO:0000269|PubMed:4352905}.
CC   -!- MISCELLANEOUS: There are amides at two of the three positions 5, 10,
CC       and 11 and at one of the three positions 68, 69, and 70.
CC   -!- SIMILARITY: Belongs to the cytochrome c family. {ECO:0000305}.
CC   -!- WEB RESOURCE: Name=Protein Spotlight; Note=Life shuttle - Issue 76 of
CC       November 2006;
CC       URL="https://web.expasy.org/spotlight/back_issues/076";
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DR   PIR; A00056; CCLK.
DR   iPTMnet; P00064; -.
DR   GO; GO:0005758; C:mitochondrial intermembrane space; IEA:UniProtKB-SubCell.
DR   GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR   GO; GO:0009055; F:electron transfer activity; IEA:InterPro.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.760.10; -; 1.
DR   InterPro; IPR009056; Cyt_c-like_dom.
DR   InterPro; IPR036909; Cyt_c-like_dom_sf.
DR   InterPro; IPR002327; Cyt_c_1A/1B.
DR   PANTHER; PTHR11961; PTHR11961; 1.
DR   Pfam; PF00034; Cytochrom_C; 1.
DR   PRINTS; PR00604; CYTCHRMECIAB.
DR   SUPFAM; SSF46626; SSF46626; 1.
DR   PROSITE; PS51007; CYTC; 1.
PE   1: Evidence at protein level;
KW   Acetylation; Direct protein sequencing; Electron transport; Heme;
KW   Hydroxylation; Iron; Metal-binding; Methylation; Mitochondrion;
KW   Respiratory chain; Transport.
FT   CHAIN           1..111
FT                   /note="Cytochrome c"
FT                   /id="PRO_0000108283"
FT   BINDING         22
FT                   /ligand="heme c"
FT                   /ligand_id="ChEBI:CHEBI:61717"
FT                   /note="covalent"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00433,
FT                   ECO:0000269|PubMed:4352905"
FT   BINDING         25
FT                   /ligand="heme c"
FT                   /ligand_id="ChEBI:CHEBI:61717"
FT                   /note="covalent"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00433,
FT                   ECO:0000269|PubMed:4352905"
FT   BINDING         26
FT                   /ligand="heme c"
FT                   /ligand_id="ChEBI:CHEBI:61717"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT   BINDING         88
FT                   /ligand="heme c"
FT                   /ligand_id="ChEBI:CHEBI:61717"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT   MOD_RES         1
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000269|PubMed:4352905"
FT   MOD_RES         79
FT                   /note="Hydroxyproline; partial"
FT                   /evidence="ECO:0000269|PubMed:4352905"
FT   MOD_RES         80
FT                   /note="N6,N6,N6-trimethyllysine"
FT                   /evidence="ECO:0000269|PubMed:4352905"
FT   MOD_RES         94
FT                   /note="N6,N6,N6-trimethyllysine"
FT                   /evidence="ECO:0000269|PubMed:4352905"
SQ   SEQUENCE   111 AA;  12080 MW;  0474CF245E34E5C3 CRC64;
     ATFSZAPPGB ZKAGQKIFKL KCAQCHTVEK GAGHKQGPNL NGLFGRQSGT AAGYSYSAAN
     KNMAVVWZZB TLYDYLLNPK KYIPGTKMVF PGLKKPQDRA DLIAYLKEST A