CYC_CHICK
ID CYC_CHICK Reviewed; 105 AA.
AC P67881; P00016; Q9PRU4;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Cytochrome c;
GN Name=CYC;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=6324108; DOI=10.1093/nar/11.24.8931;
RA Limbach K.J., Wu R.;
RT "Isolation and characterization of two alleles of the chicken cytochrome c
RT gene.";
RL Nucleic Acids Res. 11:8931-8950(1983).
RN [2]
RP PROTEIN SEQUENCE OF 2-105, AND ACETYLATION AT GLY-2.
RC TISSUE=Heart;
RX PubMed=5903744; DOI=10.1016/s0021-9258(18)96945-0;
RA Chan S.K., Margoliash E.;
RT "Amino acid sequence of chicken heart cytochrome c.";
RL J. Biol. Chem. 241:507-515(1966).
CC -!- FUNCTION: Electron carrier protein. The oxidized form of the cytochrome
CC c heme group can accept an electron from the heme group of the
CC cytochrome c1 subunit of cytochrome reductase. Cytochrome c then
CC transfers this electron to the cytochrome oxidase complex, the final
CC protein carrier in the mitochondrial electron-transport chain.
CC -!- SUBCELLULAR LOCATION: Mitochondrion intermembrane space. Note=Loosely
CC associated with the inner membrane.
CC -!- PTM: Binds 1 heme c group covalently per subunit.
CC -!- SIMILARITY: Belongs to the cytochrome c family. {ECO:0000305}.
CC -!- WEB RESOURCE: Name=Protein Spotlight; Note=Life shuttle - Issue 76 of
CC November 2006;
CC URL="https://web.expasy.org/spotlight/back_issues/076";
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; K02303; AAA48741.1; -; Genomic_DNA.
DR EMBL; X00230; CAA25046.1; -; Genomic_DNA.
DR PIR; A00014; CCCH.
DR RefSeq; NP_001072946.1; NM_001079478.1.
DR RefSeq; XP_015136937.1; XM_015281451.1.
DR RefSeq; XP_015136938.1; XM_015281452.1.
DR RefSeq; XP_015136939.1; XM_015281453.1.
DR AlphaFoldDB; P67881; -.
DR SMR; P67881; -.
DR STRING; 9031.ENSGALP00000017934; -.
DR iPTMnet; P67881; -.
DR PaxDb; P67881; -.
DR Ensembl; ENSGALT00000017955; ENSGALP00000017934; ENSGALG00000011020.
DR GeneID; 420624; -.
DR KEGG; gga:420624; -.
DR CTD; 54205; -.
DR VEuPathDB; HostDB:geneid_420624; -.
DR eggNOG; KOG3453; Eukaryota.
DR GeneTree; ENSGT00940000157883; -.
DR HOGENOM; CLU_060944_3_0_1; -.
DR InParanoid; P67881; -.
DR OMA; AQCHTIN; -.
DR OrthoDB; 1533604at2759; -.
DR PhylomeDB; P67881; -.
DR Reactome; R-GGA-111457; Release of apoptotic factors from the mitochondria.
DR Reactome; R-GGA-111458; Formation of apoptosome.
DR Reactome; R-GGA-111459; Activation of caspases through apoptosome-mediated cleavage.
DR Reactome; R-GGA-3299685; Detoxification of Reactive Oxygen Species.
DR Reactome; R-GGA-5620971; Pyroptosis.
DR Reactome; R-GGA-5628897; TP53 Regulates Metabolic Genes.
DR Reactome; R-GGA-611105; Respiratory electron transport.
DR Reactome; R-GGA-9627069; Regulation of the apoptosome activity.
DR Reactome; R-GGA-9707564; Cytoprotection by HMOX1.
DR PRO; PR:P67881; -.
DR Proteomes; UP000000539; Chromosome 2.
DR Bgee; ENSGALG00000011020; Expressed in heart and 14 other tissues.
DR GO; GO:0005737; C:cytoplasm; IDA:AgBase.
DR GO; GO:0005758; C:mitochondrial intermembrane space; IBA:GO_Central.
DR GO; GO:0005739; C:mitochondrion; IDA:AgBase.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0009055; F:electron transfer activity; IEA:InterPro.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006123; P:mitochondrial electron transport, cytochrome c to oxygen; IBA:GO_Central.
DR GO; GO:0006122; P:mitochondrial electron transport, ubiquinol to cytochrome c; IBA:GO_Central.
DR GO; GO:0043280; P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; IBA:GO_Central.
DR Gene3D; 1.10.760.10; -; 1.
DR InterPro; IPR009056; Cyt_c-like_dom.
DR InterPro; IPR036909; Cyt_c-like_dom_sf.
DR InterPro; IPR002327; Cyt_c_1A/1B.
DR PANTHER; PTHR11961; PTHR11961; 1.
DR Pfam; PF00034; Cytochrom_C; 1.
DR PRINTS; PR00604; CYTCHRMECIAB.
DR SUPFAM; SSF46626; SSF46626; 1.
DR PROSITE; PS51007; CYTC; 1.
PE 1: Evidence at protein level;
KW Acetylation; Direct protein sequencing; Electron transport; Heme; Iron;
KW Metal-binding; Mitochondrion; Reference proteome; Respiratory chain;
KW Transport.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000269|PubMed:5903744"
FT CHAIN 2..105
FT /note="Cytochrome c"
FT /id="PRO_0000108239"
FT BINDING 15
FT /ligand="heme c"
FT /ligand_id="ChEBI:CHEBI:61717"
FT /note="covalent"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00433,
FT ECO:0000269|PubMed:5903744"
FT BINDING 18
FT /ligand="heme c"
FT /ligand_id="ChEBI:CHEBI:61717"
FT /note="covalent"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00433,
FT ECO:0000269|PubMed:5903744"
FT BINDING 19
FT /ligand="heme c"
FT /ligand_id="ChEBI:CHEBI:61717"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="axial binding residue"
FT BINDING 81
FT /ligand="heme c"
FT /ligand_id="ChEBI:CHEBI:61717"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="axial binding residue"
FT MOD_RES 2
FT /note="N-acetylglycine"
FT /evidence="ECO:0000269|PubMed:5903744"
SQ SEQUENCE 105 AA; 11711 MW; 293CEF5B11DABC36 CRC64;
MGDIEKGKKI FVQKCSQCHT VEKGGKHKTG PNLHGLFGRK TGQAEGFSYT DANKNKGITW
GEDTLMEYLE NPKKYIPGTK MIFAGIKKKS ERVDLIAYLK DATSK
