ID   CYC_DANRE               Reviewed;         104 AA.
AC   Q6IQM2;
DT   01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   03-AUG-2022, entry version 126.
DE   RecName: Full=Cytochrome c;
GN   Name=cyc; ORFNames=zgc:86706;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Electron carrier protein. The oxidized form of the cytochrome
CC       c heme group can accept an electron from the heme group of the
CC       cytochrome c1 subunit of cytochrome reductase. Cytochrome c then
CC       transfers this electron to the cytochrome oxidase complex, the final
CC       protein carrier in the mitochondrial electron-transport chain (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion intermembrane space {ECO:0000250}.
CC       Note=Loosely associated with the inner membrane. {ECO:0000250}.
CC   -!- PTM: Binds 1 heme c group covalently per subunit. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the cytochrome c family. {ECO:0000305}.
CC   -!- WEB RESOURCE: Name=Protein Spotlight; Note=Life shuttle - Issue 76 of
CC       November 2006;
CC       URL="https://web.expasy.org/spotlight/back_issues/076";
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DR   EMBL; BC071383; AAH71383.1; -; mRNA.
DR   RefSeq; NP_001002068.1; NM_001002068.1.
DR   AlphaFoldDB; Q6IQM2; -.
DR   SMR; Q6IQM2; -.
DR   STRING; 7955.ENSDARP00000034555; -.
DR   PaxDb; Q6IQM2; -.
DR   PRIDE; Q6IQM2; -.
DR   Ensembl; ENSDART00000036456; ENSDARP00000034555; ENSDARG00000044562.
DR   GeneID; 415158; -.
DR   KEGG; dre:415158; -.
DR   CTD; 415158; -.
DR   ZFIN; ZDB-GENE-040625-38; cycsb.
DR   eggNOG; KOG3453; Eukaryota.
DR   GeneTree; ENSGT00940000157883; -.
DR   HOGENOM; CLU_060944_3_0_1; -.
DR   InParanoid; Q6IQM2; -.
DR   OMA; AQCHTIN; -.
DR   OrthoDB; 1533604at2759; -.
DR   PhylomeDB; Q6IQM2; -.
DR   TreeFam; TF300226; -.
DR   Reactome; R-DRE-111457; Release of apoptotic factors from the mitochondria.
DR   Reactome; R-DRE-111458; Formation of apoptosome.
DR   Reactome; R-DRE-111459; Activation of caspases through apoptosome-mediated cleavage.
DR   Reactome; R-DRE-2151201; Transcriptional activation of mitochondrial biogenesis.
DR   Reactome; R-DRE-3299685; Detoxification of Reactive Oxygen Species.
DR   Reactome; R-DRE-5620971; Pyroptosis.
DR   Reactome; R-DRE-5628897; TP53 Regulates Metabolic Genes.
DR   Reactome; R-DRE-611105; Respiratory electron transport.
DR   Reactome; R-DRE-9627069; Regulation of the apoptosome activity.
DR   Reactome; R-DRE-9707564; Cytoprotection by HMOX1.
DR   PRO; PR:Q6IQM2; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 6.
DR   Bgee; ENSDARG00000044562; Expressed in somite and 29 other tissues.
DR   GO; GO:0005758; C:mitochondrial intermembrane space; IBA:GO_Central.
DR   GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR   GO; GO:0009055; F:electron transfer activity; IEA:InterPro.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006123; P:mitochondrial electron transport, cytochrome c to oxygen; IBA:GO_Central.
DR   GO; GO:0006122; P:mitochondrial electron transport, ubiquinol to cytochrome c; IBA:GO_Central.
DR   GO; GO:0043280; P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; IBA:GO_Central.
DR   Gene3D; 1.10.760.10; -; 1.
DR   InterPro; IPR009056; Cyt_c-like_dom.
DR   InterPro; IPR036909; Cyt_c-like_dom_sf.
DR   InterPro; IPR002327; Cyt_c_1A/1B.
DR   PANTHER; PTHR11961; PTHR11961; 1.
DR   Pfam; PF00034; Cytochrom_C; 1.
DR   PRINTS; PR00604; CYTCHRMECIAB.
DR   SUPFAM; SSF46626; SSF46626; 1.
DR   PROSITE; PS51007; CYTC; 1.
PE   3: Inferred from homology;
KW   Acetylation; Electron transport; Heme; Iron; Metal-binding; Mitochondrion;
KW   Reference proteome; Respiratory chain; Transport.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..104
FT                   /note="Cytochrome c"
FT                   /id="PRO_0000108250"
FT   BINDING         15
FT                   /ligand="heme c"
FT                   /ligand_id="ChEBI:CHEBI:61717"
FT                   /note="covalent"
FT   BINDING         18
FT                   /ligand="heme c"
FT                   /ligand_id="ChEBI:CHEBI:61717"
FT                   /note="covalent"
FT   BINDING         19
FT                   /ligand="heme c"
FT                   /ligand_id="ChEBI:CHEBI:61717"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT   BINDING         81
FT                   /ligand="heme c"
FT                   /ligand_id="ChEBI:CHEBI:61717"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT   MOD_RES         2
FT                   /note="N-acetylglycine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   104 AA;  11456 MW;  23E5CF518C9C3C5F CRC64;
     MGDVEKGKKV FVQKCAQCHT VENGGKHKVG PNLWGLFGRK TGQAEGFSYT DANKSKGIVW
     GEDTLMEYLE NPKKYIPGTK MIFAGIKKKG ERADLIAYLK SATS