ID   CYC_TRYBB               Reviewed;          93 AA.
AC   P18822;
DT   01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1990, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Cytochrome c;
DE   Flags: Fragments;
OS   Trypanosoma brucei brucei.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX   NCBI_TaxID=5702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 25-93, AND PROTEIN SEQUENCE OF 1-24.
RX   PubMed=2850466; DOI=10.1128/mcb.8.11.4625-4633.1988;
RA   Torri A.F., Hajduk S.L.;
RT   "Posttranscriptional regulation of cytochrome c expression during the
RT   developmental cycle of Trypanosoma brucei.";
RL   Mol. Cell. Biol. 8:4625-4633(1988).
CC   -!- FUNCTION: Electron carrier protein. The oxidized form of the cytochrome
CC       c heme group can accept an electron from the heme group of the
CC       cytochrome c1 subunit of cytochrome reductase. Cytochrome c then
CC       transfers this electron to the cytochrome oxidase complex, the final
CC       protein carrier in the mitochondrial electron-transport chain.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion intermembrane space. Note=Loosely
CC       associated with the inner membrane.
CC   -!- PTM: Binds 1 heme c group covalently per subunit.
CC   -!- SIMILARITY: Belongs to the cytochrome c family. {ECO:0000305}.
CC   -!- WEB RESOURCE: Name=Protein Spotlight; Note=Life shuttle - Issue 76 of
CC       November 2006;
CC       URL="https://web.expasy.org/spotlight/back_issues/076";
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DR   EMBL; M23360; AAA30178.1; -; mRNA.
DR   PIR; B31558; A31558.
DR   AlphaFoldDB; P18822; -.
DR   SMR; P18822; -.
DR   GO; GO:0005758; C:mitochondrial intermembrane space; IEA:UniProtKB-SubCell.
DR   GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR   GO; GO:0009055; F:electron transfer activity; IEA:InterPro.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.760.10; -; 1.
DR   InterPro; IPR009056; Cyt_c-like_dom.
DR   InterPro; IPR036909; Cyt_c-like_dom_sf.
DR   InterPro; IPR002327; Cyt_c_1A/1B.
DR   PANTHER; PTHR11961; PTHR11961; 1.
DR   Pfam; PF00034; Cytochrom_C; 1.
DR   PRINTS; PR00604; CYTCHRMECIAB.
DR   SUPFAM; SSF46626; SSF46626; 1.
DR   PROSITE; PS51007; CYTC; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Electron transport; Heme; Iron; Metal-binding;
KW   Mitochondrion; Respiratory chain; Transport.
FT   CHAIN           <1..>93
FT                   /note="Cytochrome c"
FT                   /id="PRO_0000108280"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         70
FT                   /ligand="heme c"
FT                   /ligand_id="ChEBI:CHEBI:61717"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT   NON_CONS        9..10
FT                   /evidence="ECO:0000305"
FT   NON_CONS        12..13
FT                   /evidence="ECO:0000305"
FT   NON_TER         1
FT   NON_TER         93
SQ   SEQUENCE   93 AA;  9833 MW;  28251402407F871B CRC64;
     AALPPGDAAA AQGGSNGVGP NLYGIVGRKS GTVEGFTYSK ANQDSGVMWT PQVLDVYLEN
     PKKFMPGTKM SFAGLKKPQE RADLIAYLET LKD