CYDC_ECOLI
ID CYDC_ECOLI Reviewed; 573 AA.
AC P23886;
DT 01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-1993, sequence version 2.
DT 03-AUG-2022, entry version 179.
DE RecName: Full=ATP-binding/permease protein CydC;
GN Name=cydC; Synonyms=mdrA, mdrH, surB; OrderedLocusNames=b0886, JW0869;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=K12 / MC1061 / ATCC 53338 / DSM 7140;
RX PubMed=8331068; DOI=10.1128/jb.175.14.4364-4374.1993;
RA Shrader T.E., Tobias J.W., Varshavsky A.;
RT "The N-end rule in Escherichia coli: cloning and analysis of the leucyl,
RT phenylalanyl-tRNA-protein transferase gene aat.";
RL J. Bacteriol. 175:4364-4374(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8276245; DOI=10.1101/gad.7.12b.2629;
RA Siegele D.D., Kolter R.;
RT "Isolation and characterization of an Escherichia coli mutant defective in
RT resuming growth after starvation.";
RL Genes Dev. 7:2629-2640(1993).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=8905232; DOI=10.1093/dnares/3.3.137;
RA Oshima T., Aiba H., Baba T., Fujita K., Hayashi K., Honjo A., Ikemoto K.,
RA Inada T., Itoh T., Kajihara M., Kanai K., Kashimoto K., Kimura S.,
RA Kitagawa M., Makino K., Masuda S., Miki T., Mizobuchi K., Mori H.,
RA Motomura K., Nakamura Y., Nashimoto H., Nishio Y., Saito N., Sampei G.,
RA Seki Y., Tagami H., Takemoto K., Wada C., Yamamoto Y., Yano M.,
RA Horiuchi T.;
RT "A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to
RT the 12.7-28.0 min region on the linkage map.";
RL DNA Res. 3:137-155(1996).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [6]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-453.
RX PubMed=7934832; DOI=10.1111/j.1365-2958.1993.tb02673.x;
RA Poole R.K., Hatch L., Cleeter M.W.J., Gibson F., Cox G.B., Wu G.;
RT "Cytochrome bd biosynthesis in Escherichia coli: the sequences of the cydC
RT and cydD genes suggest that they encode the components of an ABC membrane
RT transporter.";
RL Mol. Microbiol. 10:421-430(1993).
RN [7]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 449-504.
RX PubMed=1909328; DOI=10.1016/s0021-9258(18)55327-8;
RA Cummings H.S., Sands J.F., Foreman P.C., Fraser J., Hershey J.W.B.;
RT "Structure and expression of the infA operon encoding translational
RT initiation factor IF1. Transcriptional control by growth rate.";
RL J. Biol. Chem. 266:16491-16498(1991).
RN [8]
RP SUBCELLULAR LOCATION.
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=15919996; DOI=10.1126/science.1109730;
RA Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.;
RT "Global topology analysis of the Escherichia coli inner membrane
RT proteome.";
RL Science 308:1321-1323(2005).
CC -!- FUNCTION: Somehow involved in the cytochrome D branch of aerobic
CC respiration. Seems to be a component of a transport system.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein
CC {ECO:0000255|PROSITE-ProRule:PRU00441, ECO:0000269|PubMed:15919996}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. Cysteine
CC exporter (TC 3.A.1.129.1) family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; L10383; AAA03230.1; -; Unassigned_DNA.
DR EMBL; L25859; AAC36864.1; -; Unassigned_DNA.
DR EMBL; U00096; AAC73972.1; -; Genomic_DNA.
DR EMBL; AP009048; BAA35611.1; -; Genomic_DNA.
DR EMBL; M63145; AAC36909.1; -; Genomic_DNA.
DR EMBL; L21749; AAA66172.1; -; Genomic_DNA.
DR PIR; B36888; B36888.
DR RefSeq; NP_415406.1; NC_000913.3.
DR RefSeq; WP_001202177.1; NZ_LN832404.1.
DR AlphaFoldDB; P23886; -.
DR SMR; P23886; -.
DR BioGRID; 4260004; 302.
DR ComplexPortal; CPX-4601; Glutathione/cysteine ABC exporter complex.
DR DIP; DIP-9362N; -.
DR IntAct; P23886; 6.
DR STRING; 511145.b0886; -.
DR TCDB; 3.A.1.129.1; the atp-binding cassette (abc) superfamily.
DR jPOST; P23886; -.
DR PaxDb; P23886; -.
DR PRIDE; P23886; -.
DR EnsemblBacteria; AAC73972; AAC73972; b0886.
DR EnsemblBacteria; BAA35611; BAA35611; BAA35611.
DR GeneID; 945504; -.
DR KEGG; ecj:JW0869; -.
DR KEGG; eco:b0886; -.
DR PATRIC; fig|1411691.4.peg.1392; -.
DR EchoBASE; EB0012; -.
DR eggNOG; COG4987; Bacteria.
DR HOGENOM; CLU_000604_84_9_6; -.
DR InParanoid; P23886; -.
DR OMA; VYQEIYY; -.
DR PhylomeDB; P23886; -.
DR BioCyc; EcoCyc:CYDC-MON; -.
DR BioCyc; MetaCyc:CYDC-MON; -.
DR PRO; PR:P23886; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0043190; C:ATP-binding cassette (ABC) transporter complex; ISM:EcoCyc.
DR GO; GO:0016021; C:integral component of membrane; IDA:EcoCyc.
DR GO; GO:0005887; C:integral component of plasma membrane; IDA:EcoCyc.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IDA:EcoCyc.
DR GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IDA:EcoCyc.
DR GO; GO:0045454; P:cell redox homeostasis; IC:ComplexPortal.
DR GO; GO:0033228; P:cysteine export across plasma membrane; IDA:EcoCyc.
DR GO; GO:0034775; P:glutathione transmembrane transport; IDA:EcoCyc.
DR GO; GO:0070453; P:regulation of heme biosynthetic process; IMP:EcoCyc.
DR Gene3D; 1.20.1560.10; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011527; ABC1_TM_dom.
DR InterPro; IPR036640; ABC1_TM_sf.
DR InterPro; IPR014223; ABC_CydC.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00664; ABC_membrane; 1.
DR Pfam; PF00005; ABC_tran; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR SUPFAM; SSF90123; SSF90123; 1.
DR TIGRFAMs; TIGR02868; CydC; 1.
DR PROSITE; PS50929; ABC_TM1F; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cell inner membrane; Cell membrane; Membrane;
KW Nucleotide-binding; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..573
FT /note="ATP-binding/permease protein CydC"
FT /id="PRO_0000092241"
FT TRANSMEM 16..36
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 37..57
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 137..157
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 162..182
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 250..270
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 277..297
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 18..306
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 339..572
FT /note="ABC transporter"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 373..380
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT CONFLICT 289
FT /note="A -> R (in Ref. 2; AAC36864)"
FT /evidence="ECO:0000305"
FT CONFLICT 480..481
FT /note="LR -> PG (in Ref. 2; AAC36864)"
FT /evidence="ECO:0000305"
FT CONFLICT 504
FT /note="G -> A (in Ref. 7; AAC36909)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 573 AA; 62920 MW; ACF4E7087EEEADAD CRC64;
MRALLPYLAL YKRHKWMLSL GIVLAIVTLL ASIGLLTLSG WFLSASAVAG VAGLYSFNYM
LPAAGVRGAA ITRTAGRYFE RLVSHDATFR VLQHLRIYTF SKLLPLSPAG LARYRQGELL
NRVVADVDTL DHLYLRVISP LVGAFVVIMV VTIGLSFLDF TLAFTLGGIM LLTLFLMPPL
FYRAGKSTGQ NLTHLRGQYR QQLTAWLQGQ AELTIFGASD RYRTQLENTE IQWLEAQRRQ
SELTALSQAI MLLIGALAVI LMLWMASGGV GGNAQPGALI ALFVFCALAA FEALAPVTGA
FQHLGQVIAS AVRISDLTDQ KPEVTFPDTQ TRVADRVSLT LRDVQFTYPE QSQQALKGIS
LQVNAGEHIA ILGRTGCGKS TLLQQLTRAW DPQQGEILLN DSPIASLNEA ALRQTISVVP
QRVHLFSATL RDNLLLASPG SSDEALSEIL RRVGLEKLLE DAGLNSWLGE GGRQLSGGEL
RRLAIARALL HDAPLVLLDE PTEGLDATTE SQILELLAEM MREKTVLMVT HRLRGLSRFQ
QIIVMDNGQI IEQGTHAELL ARQGRYYQFK QGL
