CYDC_HAEIN
ID CYDC_HAEIN Reviewed; 576 AA.
AC P45081;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=ATP-binding/permease protein CydC;
GN Name=cydC; OrderedLocusNames=HI_1156;
OS Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=71421;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX PubMed=7542800; DOI=10.1126/science.7542800;
RA Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT Rd.";
RL Science 269:496-512(1995).
CC -!- FUNCTION: Somehow involved in the cytochrome D branch of aerobic
CC respiration. Seems to be a component of a transport system (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. Cysteine
CC exporter (TC 3.A.1.129.1) family. {ECO:0000305}.
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DR EMBL; L42023; AAC22811.1; -; Genomic_DNA.
DR PIR; E64186; E64186.
DR RefSeq; NP_439314.1; NC_000907.1.
DR RefSeq; WP_005693471.1; NC_000907.1.
DR AlphaFoldDB; P45081; -.
DR SMR; P45081; -.
DR STRING; 71421.HI_1156; -.
DR EnsemblBacteria; AAC22811; AAC22811; HI_1156.
DR KEGG; hin:HI_1156; -.
DR PATRIC; fig|71421.8.peg.1207; -.
DR eggNOG; COG4987; Bacteria.
DR HOGENOM; CLU_000604_84_9_6; -.
DR OMA; VSHNATF; -.
DR PhylomeDB; P45081; -.
DR BioCyc; HINF71421:G1GJ1-1190-MON; -.
DR Proteomes; UP000000579; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0045454; P:cell redox homeostasis; IEA:InterPro.
DR GO; GO:0033228; P:cysteine export across plasma membrane; IBA:GO_Central.
DR GO; GO:0034775; P:glutathione transmembrane transport; IEA:InterPro.
DR Gene3D; 1.20.1560.10; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011527; ABC1_TM_dom.
DR InterPro; IPR036640; ABC1_TM_sf.
DR InterPro; IPR014223; ABC_CydC.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00664; ABC_membrane; 1.
DR Pfam; PF00005; ABC_tran; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR SUPFAM; SSF90123; SSF90123; 1.
DR TIGRFAMs; TIGR02868; CydC; 1.
DR PROSITE; PS50929; ABC_TM1F; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cell inner membrane; Cell membrane; Membrane;
KW Nucleotide-binding; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..576
FT /note="ATP-binding/permease protein CydC"
FT /id="PRO_0000092242"
FT TRANSMEM 16..36
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 38..58
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 133..153
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 155..175
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 244..264
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 281..301
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 18..308
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 338..574
FT /note="ABC transporter"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 372..379
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ SEQUENCE 576 AA; 64832 MW; A9ACD8B9B294B1B3 CRC64;
MRTLLPFIRL FKFAKFPLIL GLVLMILGLG SSMGLLTVSG WFLAATAIAG LGTLFNFFYP
SASVRGLAIG RTVMRYFEKI VTHDATFRIL SKLRVQVFEK IIPLSPAVLN RYRNSDLLNR
LVSDVDTLDS LYLRLLAPFF TAVFVIIAMM IGLSFINIPL ALGLGLFLLI LLMIIPTVFY
RLGQQFGERL IQARATYRTQ FLEFIQAQAE LLLFNAEDKL KEKMLVTEKT WQEDQAKEAK
LSGFSTALVL FLNGLLISGM LWFASNADFG TDEYHTAYIA LFTFAALAAF EIIMPLGAAF
LHIGQVIAAA ERVTEIIEQK PLVEFNGNEE FETKVRLISA KNLNFSYPEQ ETLVLKNLTL
DLEQGKKIAI LGKTGSGKSS LLQLLVRNYD ANQGELLLAE KPISAYSEET LRHQICFLTQ
RVHVFSDTLR QNLQFASADK ISDEQMIEML HQVGLSKLLE QEGKGLNLWL GDGGRPLSGG
EQRRLGLARI LLNNASILLL DEPTEGLDRE TERQILRLIL QHAENKTLII VTHRLSSIEQ
FDKICVIDNG RLIEEGDYNS LITKENGFFK RLIERV
