CYDD_HAEIN
ID CYDD_HAEIN Reviewed; 586 AA.
AC P45082;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=ATP-binding/permease protein CydD;
GN Name=cydD; OrderedLocusNames=HI_1157;
OS Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=71421;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX PubMed=7542800; DOI=10.1126/science.7542800;
RA Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT Rd.";
RL Science 269:496-512(1995).
CC -!- FUNCTION: Somehow involved in the cytochrome D branch of aerobic
CC respiration. Seems to be a component of a transport system (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. Cysteine
CC exporter (TC 3.A.1.129.1) family. {ECO:0000305}.
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DR EMBL; L42023; AAC22812.1; -; Genomic_DNA.
DR PIR; F64186; F64186.
DR RefSeq; NP_439315.1; NC_000907.1.
DR RefSeq; WP_005693472.1; NC_000907.1.
DR AlphaFoldDB; P45082; -.
DR SMR; P45082; -.
DR STRING; 71421.HI_1157; -.
DR EnsemblBacteria; AAC22812; AAC22812; HI_1157.
DR KEGG; hin:HI_1157; -.
DR PATRIC; fig|71421.8.peg.1208; -.
DR eggNOG; COG4988; Bacteria.
DR HOGENOM; CLU_000604_84_9_6; -.
DR OMA; FPLNWAA; -.
DR PhylomeDB; P45082; -.
DR BioCyc; HINF71421:G1GJ1-1191-MON; -.
DR Proteomes; UP000000579; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0042883; P:cysteine transport; IEA:InterPro.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR Gene3D; 1.20.1560.10; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011527; ABC1_TM_dom.
DR InterPro; IPR036640; ABC1_TM_sf.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR014216; ABC_transptr_CydD.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR039421; Type_1_exporter.
DR PANTHER; PTHR24221; PTHR24221; 1.
DR Pfam; PF00664; ABC_membrane; 1.
DR Pfam; PF00005; ABC_tran; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR SUPFAM; SSF90123; SSF90123; 1.
DR TIGRFAMs; TIGR02857; CydD; 1.
DR PROSITE; PS50929; ABC_TM1F; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cell inner membrane; Cell membrane; Membrane;
KW Nucleotide-binding; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..586
FT /note="ATP-binding/permease protein CydD"
FT /id="PRO_0000092245"
FT TRANSMEM 28..48
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 62..82
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 146..166
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 167..187
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 250..270
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 278..298
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 24..316
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 350..581
FT /note="ABC transporter"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 383..390
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ SEQUENCE 586 AA; 65645 MW; A01E8A9920BB5966 CRC64;
MNKLRQKYLQ KWLRAQQEPI KKLMRANIVL ATLSSFILVA QTYFLATLLD KLIMQNVPRD
ELIPYFLGLI IGFGMRAIIL WAREKIGFQS GQLLRNHIRQ KILDKIHLVG PATINQKPAG
SWASIMLEQV ENLHNFYARF LPQQSLSAIV PVVIFIAVFP LNWAAGLILM ITAPLVPLFM
IIVGIAAADN SQKNMDTLSR LSAQFLDRLR GLETLRLFNR TSEQTEHIEN ATEDFRETTM
DVLKLAFLSS AVLEFFTSIS IALMAVYFGF SYLGQIEFGT YNAPLTLFTG FFCLILAPEF
YQPLRDLGTY YHDRAAGIGA ADAIVDFLES DYLTVHQNEK TISLESAVEI SAENLVVLST
QGSALTKPLN FQIPANHNVA LVGQSGAGKT SLMNVILGFL PYEGSLKING QELRESNLAD
WRKHIAWVGQ NPLLLQGTIK ENLLLGDVQA NDEEINQALM RSQAKEFTDK LGLHHEIKDG
GLGISVGQAQ RLAIARALLR KGDLLLLDEP TASLDAQSEN LVLQALNEAS QHQTTLMITH
RIEDLKQCDQ IFVMQRGEIV QQGKFTELQH EGFFAELLAQ RQQDIQ
