ID   CYFP2_XENLA             Reviewed;        1253 AA.
AC   Q6GQD1;
DT   06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 59.
DE   RecName: Full=Cytoplasmic FMR1-interacting protein 2;
GN   Name=cyfip2;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1] {ECO:0000312|EMBL:AAH72814.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo {ECO:0000312|EMBL:AAH72814.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in T-cell adhesion and p53-dependent induction of
CC       apoptosis. Does not bind RNA (By similarity).
CC       {ECO:0000250|UniProtKB:Q5SQX6, ECO:0000250|UniProtKB:Q96F07}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q96F07}.
CC   -!- SIMILARITY: Belongs to the CYFIP family. {ECO:0000255}.
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DR   EMBL; BC072814; AAH72814.1; -; mRNA.
DR   RefSeq; NP_001085471.1; NM_001092002.1.
DR   AlphaFoldDB; Q6GQD1; -.
DR   SMR; Q6GQD1; -.
DR   MaxQB; Q6GQD1; -.
DR   DNASU; 443897; -.
DR   GeneID; 443897; -.
DR   KEGG; xla:443897; -.
DR   CTD; 443897; -.
DR   Xenbase; XB-GENE-922706; cyfip2.S.
DR   Proteomes; UP000186698; Chromosome 3S.
DR   Bgee; 443897; Expressed in brain and 20 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR   GO; GO:0030833; P:regulation of actin filament polymerization; IEA:InterPro.
DR   InterPro; IPR009828; CYRIA/CYRIB_Rac1-bd.
DR   InterPro; IPR008081; Cytoplasmic_FMR1-int.
DR   PANTHER; PTHR12195; PTHR12195; 1.
DR   Pfam; PF07159; DUF1394; 1.
DR   Pfam; PF05994; FragX_IP; 1.
DR   PIRSF; PIRSF008153; FMR1_interacting; 1.
DR   PRINTS; PR01698; CYTOFMRPINTP.
PE   2: Evidence at transcript level;
KW   Apoptosis; Cell adhesion; Cytoplasm; Reference proteome; RNA editing.
FT   CHAIN           1..1253
FT                   /note="Cytoplasmic FMR1-interacting protein 2"
FT                   /id="PRO_0000279712"
SQ   SEQUENCE   1253 AA;  145638 MW;  306621A4ABBC0E1B CRC64;
     MTTHVTLEDA LSNVDLLEEL PLPDQQPCIE PPPSSIMYQA NFDTNFEDRN AFVTGIARYI
     EQATVHSSMN EMLEEGQEYA VMLYTWRSCS RAIPQVKCNE QPNRVEIYEK TVEVLEPEVT
     KLMKFMYFQR KAIERFCNEV KRLCHTERRK DFVSEAYLLT LGKFINMFAV LDELKNMKCS
     VKNDHSAYKR AAQFLRKMAD PQSIQESQNL SMFLANHNRI TQCLHQQLEV IPGYEELLAD
     IVNICVDYYE NKMYLTPSEK HMLLKVMGFG LYLMDGNVSN IYKLDAKKRI NLSKIDKFFK
     QLQVVPLFGD MQIELARYIE TSAHYEENKS KWTCTQSSIS PQYNICEQMV QIRDDHIRFI
     SELARYSNSE VVTGSGLDSQ KSDEEYRELF DLALRGLQLL SKWSAHVMEV YSWKLVHPTD
     KFCNKDCPGT AEEYERATRY NYTSEEKFAF VEVIAMVKGL QVLMGRMESV FNQAIRNTIY
     AALQDFAQSS LREPLRQAVR KKKNVLISVL QAIRKTVCDW EAGREPPNDP CLRGEKDPKG
     GFDINVPRRA VGPSSTQLYM VRTMLESLIA DKSGSKKTLR SSLDGPIVQA IEEFHKQSFF
     FTHLLNFSEA LQQCCDLSQL WFREFFLELT MGRRIQFPIE MSMPWILTDH ILETKEPSMM
     EYVLYPLDLY NDSAYYALTK FKKQFLYDEI EAEVNLCFDQ FVYKLSDQIF AYYKAMSGSV
     LLDKRFRAEC KNYGVIIPYP PSNRYETLLK QRHVQLLGRS IDLNRLITQR ISAAMYKSLD
     QAISRFESED LTSIVELEWL LDINRLTHRL LSKHLTLDSF DAMFREANHN VSAPYGRNTL
     HVFWELNFDF LPNYCYNGST NRFVRTAIPF TQEPQRDKPA NVQPYYLYGS KPLNIAYSHI
     YSSYRNFVGP PHFKTICRLL GYQGIAVVME ELLKIVKSLL QGTVLQYVKT LIEVMPKICR
     LPRHEYGSPG ILEFFHHQLK DIIEYAELKT DVFQSLREVG NAILFCLLIE QALSQEEVCD
     LLHAAPFQNI LPRVYIKEGE RLEVRMKRLE AKYAPLHLVP LIERLGTPQQ IAIAREGDLL
     TKERLCCGLS MFEVILTRIR SYLQDPIWRG PPPTNGVMHV DECVELHRLW SAMQFVYCIP
     VGTNEFTAEQ CFGDGLNWAG CAIIVLLGQQ RRFDLFDFCY HLLKVQRQDG KDEIIKNVPL
     KKMADRIRKY QILNNEIFAV LNKYMKSVES DSSTVEHVRC FQPPIHQSLA TTC