ID   ACSA_COPCI              Reviewed;         661 AA.
AC   O13440; O13441;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=Acetyl-coenzyme A synthetase;
DE            EC=6.2.1.1;
DE   AltName: Full=Acetate--CoA ligase;
DE   AltName: Full=Acyl-activating enzyme;
GN   Name=ACS-1;
OS   Coprinopsis cinerea (Inky cap fungus) (Hormographiella aspergillata).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC   Agaricomycetidae; Agaricales; Psathyrellaceae; Coprinopsis.
OX   NCBI_TaxID=5346;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC   STRAIN=JV6;
RA   Chaure P.T., Casselton L.A., Connerton I.F.;
RL   Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate;
CC         Xref=Rhea:RHEA:23176, ChEBI:CHEBI:30089, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288,
CC         ChEBI:CHEBI:456215; EC=6.2.1.1;
CC   -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC       {ECO:0000305}.
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DR   EMBL; Y15417; CAA75612.1; -; mRNA.
DR   EMBL; Y15418; CAA75613.1; -; Genomic_DNA.
DR   AlphaFoldDB; O13440; -.
DR   SMR; O13440; -.
DR   VEuPathDB; FungiDB:CC1G_09467; -.
DR   VEuPathDB; FungiDB:CC2G_014513; -.
DR   GO; GO:0003987; F:acetate-CoA ligase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016208; F:AMP binding; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0019427; P:acetyl-CoA biosynthetic process from acetate; IEA:InterPro.
DR   Gene3D; 3.30.300.30; -; 1.
DR   Gene3D; 3.40.50.12780; -; 1.
DR   InterPro; IPR011904; Ac_CoA_lig.
DR   InterPro; IPR032387; ACAS_N.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig.
DR   InterPro; IPR042099; ANL_N_sf.
DR   Pfam; PF16177; ACAS_N; 1.
DR   Pfam; PF00501; AMP-binding; 1.
DR   Pfam; PF13193; AMP-binding_C; 1.
DR   TIGRFAMs; TIGR02188; Ac_CoA_lig_AcsA; 1.
DR   PROSITE; PS00455; AMP_BINDING; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Ligase; Nucleotide-binding.
FT   CHAIN           1..661
FT                   /note="Acetyl-coenzyme A synthetase"
FT                   /id="PRO_0000208409"
FT   BINDING         199..202
FT                   /ligand="CoA"
FT                   /ligand_id="ChEBI:CHEBI:57287"
FT                   /evidence="ECO:0000250"
FT   BINDING         317
FT                   /ligand="CoA"
FT                   /ligand_id="ChEBI:CHEBI:57287"
FT                   /evidence="ECO:0000250"
FT   BINDING         393..395
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250"
FT   BINDING         417..422
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250"
FT   BINDING         508
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250"
FT   BINDING         523
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250"
FT   BINDING         531
FT                   /ligand="CoA"
FT                   /ligand_id="ChEBI:CHEBI:57287"
FT                   /evidence="ECO:0000250"
FT   BINDING         534
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250"
FT   BINDING         596
FT                   /ligand="CoA"
FT                   /ligand_id="ChEBI:CHEBI:57287"
FT                   /evidence="ECO:0000250"
FT   CONFLICT        14
FT                   /note="A -> G (in Ref. 1; CAA75613)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        644
FT                   /note="F -> L (in Ref. 1; CAA75613)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   661 AA;  73094 MW;  D647C974095795D9 CRC64;
     MSEGPIRVAP HPIAKRVKHG CKTPHVSHID DYRSQHRETI GHESDKWWAK KAHELLYWDR
     PFHTVRSGSF ENGDIAWFPE GGLNASYNCV DRWAFKHPEK TAIIYEADEP GEGREISYAE
     LLREVCSIAN VLKSFGVKKG DTVSVYLPMT WQAVAAFLAC ARIGAIHSVV FAGFSAEALR
     DRMQDCKSRV LITSDEGRRG GKAIATKAIA DAALKECPAV EKVLVLKRTG NPVPWTEGRD
     VWWHEAVARV PRYCPPEVMA SEDPLFILYT SGSTGKPKGV VHTTGGYLLC AALTVKYVFD
     VHPDDRFACM ADVGWITGHT YIVYGPLAIG ATTTVFESTP VYPTPSRYWE TVEKYKLTQF
     YSAPTAIRLL RRLGHEHVNK HDLSSLRVLG SVGEPINPEA WHWYNEHVGK TECAIVDTFW
     QTETGSIVVT PFPGAIETKP GAATVPFFGI EPAILEPTTG KVLEGNDVEG VLTIAHPWPS
     IARTIYGDHQ RYLETYMKPY PGYFYTGDGA ARDEDGYIWI KGRVDDVINV SGHRLSTAEI
     ESALITHTGV AETAVIGTAD ELTGQAVYAF VTLKPEFKFD AENEAGLSKE LILQVRKIIG
     PFAAPKRIYI VSDLPKTRSG KIMRRILRKI VAGEADQLGD LSTFADPGIV EVIKEKVASA
     A