ID   CYGB1_DANRE             Reviewed;         174 AA.
AC   Q8UUR3; Q504J2;
DT   27-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   28-NOV-2006, sequence version 2.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Cytoglobin-1;
GN   Name=cygb1; Synonyms=cygb, cygb-1; ORFNames=zgc:109806;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=11919282; DOI=10.1093/oxfordjournals.molbev.a004096;
RA   Burmester T., Ebner B., Weich B., Hankeln T.;
RT   "Cytoglobin: a novel globin type ubiquitously expressed in vertebrate
RT   tissues.";
RL   Mol. Biol. Evol. 19:416-421(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Larva;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   TISSUE SPECIFICITY.
RX   PubMed=16199220; DOI=10.1016/j.bbrc.2005.08.271;
RA   Fuchs C., Luckhardt A., Gerlach F., Burmester T., Hankeln T.;
RT   "Duplicated cytoglobin genes in teleost fishes.";
RL   Biochem. Biophys. Res. Commun. 337:216-223(2005).
CC   -!- FUNCTION: May have a protective function during conditions of oxidative
CC       stress. May be involved in intracellular oxygen storage or transfer.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed in all tissues examined with highest
CC       levels in brain, eye, gut and heart. {ECO:0000269|PubMed:16199220}.
CC   -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00238}.
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DR   EMBL; AJ320232; CAC86225.1; -; mRNA.
DR   EMBL; BC094999; AAH94999.1; -; mRNA.
DR   RefSeq; NP_694484.1; NM_152952.2.
DR   AlphaFoldDB; Q8UUR3; -.
DR   SMR; Q8UUR3; -.
DR   STRING; 7955.ENSDARP00000055793; -.
DR   PaxDb; Q8UUR3; -.
DR   GeneID; 246090; -.
DR   KEGG; dre:246090; -.
DR   CTD; 246090; -.
DR   ZFIN; ZDB-GENE-020513-1; cygb1.
DR   eggNOG; KOG3378; Eukaryota.
DR   InParanoid; Q8UUR3; -.
DR   OrthoDB; 1379813at2759; -.
DR   PhylomeDB; Q8UUR3; -.
DR   PRO; PR:Q8UUR3; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0098809; F:nitrite reductase activity; IDA:ZFIN.
DR   GO; GO:0019825; F:oxygen binding; IDA:ZFIN.
DR   GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR   GO; GO:0046686; P:response to cadmium ion; IEP:ZFIN.
DR   Gene3D; 1.10.490.10; -; 1.
DR   InterPro; IPR000971; Globin.
DR   InterPro; IPR009050; Globin-like_sf.
DR   InterPro; IPR012292; Globin/Proto.
DR   InterPro; IPR013314; Globin_lamprey/hagfish.
DR   PANTHER; PTHR46783; PTHR46783; 1.
DR   Pfam; PF00042; Globin; 1.
DR   PRINTS; PR01906; FISHGLOBIN.
DR   SUPFAM; SSF46458; SSF46458; 1.
DR   PROSITE; PS01033; GLOBIN; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Heme; Iron; Metal-binding; Oxygen transport; Reference proteome;
KW   Transport.
FT   CHAIN           1..174
FT                   /note="Cytoglobin-1"
FT                   /id="PRO_0000053387"
FT   REGION          14..165
FT                   /note="Globin"
FT   BINDING         78
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="distal binding residue"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00238"
FT   BINDING         110
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="proximal binding residue"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00238"
FT   CONFLICT        77
FT                   /note="E -> K (in Ref. 1; CAC86225)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   174 AA;  19909 MW;  DAAF8924E7468ECA CRC64;
     MEGDGGVQLT QSPDSLTEED VCVIQDTWKP VYAERDNAGV AVLVRFFTNF PSAKQYFEHF
     RELQDPAEMQ QNAQLKEHGQ RVLNALNTLV ENLRDADKLN TIFNQMGKSH ALRHKVDPVY
     FKILAGVILE VLVEAFPQCF SPAEVQSSWS KLMGILYWQM NRVYAEVGWE NSKK