CYGB1_ORYLA
ID CYGB1_ORYLA Reviewed; 177 AA.
AC Q575T0;
DT 28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT 10-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 78.
DE RecName: Full=Cytoglobin-1;
GN Name=cygb1 {ECO:0000250|UniProtKB:Q8UUR3};
GN Synonyms=cygb-1 {ECO:0000312|EMBL:CAG25610.1};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090;
RN [1] {ECO:0000312|EMBL:CAG25610.1}
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=16199220; DOI=10.1016/j.bbrc.2005.08.271;
RA Fuchs C., Luckhardt A., Gerlach F., Burmester T., Hankeln T.;
RT "Duplicated cytoglobin genes in teleost fishes.";
RL Biochem. Biophys. Res. Commun. 337:216-223(2005).
CC -!- FUNCTION: May have a protective function during conditions of oxidative
CC stress. May be involved in intracellular oxygen storage or transfer.
CC {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q921A4}.
CC -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC ProRule:PRU00238}.
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DR EMBL; AJ635227; CAG25610.1; -; mRNA.
DR RefSeq; NP_001098237.1; NM_001104767.1.
DR RefSeq; XP_011476171.1; XM_011477869.1.
DR AlphaFoldDB; Q575T0; -.
DR SMR; Q575T0; -.
DR STRING; 8090.ENSORLP00000015610; -.
DR Ensembl; ENSORLT00000015611; ENSORLP00000015610; ENSORLG00000012468.
DR Ensembl; ENSORLT00000015613; ENSORLP00000015612; ENSORLG00000012468.
DR GeneID; 100049376; -.
DR KEGG; ola:100049376; -.
DR CTD; 246090; -.
DR eggNOG; KOG3378; Eukaryota.
DR GeneTree; ENSGT00940000155004; -.
DR InParanoid; Q575T0; -.
DR OrthoDB; 1379813at2759; -.
DR Proteomes; UP000001038; Chromosome 8.
DR Proteomes; UP000265180; Unplaced.
DR Proteomes; UP000265200; Unplaced.
DR Bgee; ENSORLG00000012468; Expressed in intestine and 12 other tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0019825; F:oxygen binding; IEA:InterPro.
DR GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR Gene3D; 1.10.490.10; -; 1.
DR InterPro; IPR000971; Globin.
DR InterPro; IPR009050; Globin-like_sf.
DR InterPro; IPR012292; Globin/Proto.
DR InterPro; IPR013314; Globin_lamprey/hagfish.
DR PANTHER; PTHR46783; PTHR46783; 1.
DR Pfam; PF00042; Globin; 1.
DR PRINTS; PR01906; FISHGLOBIN.
DR SUPFAM; SSF46458; SSF46458; 1.
DR PROSITE; PS01033; GLOBIN; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Heme; Iron; Metal-binding; Oxygen transport; Reference proteome;
KW Transport.
FT CHAIN 1..177
FT /note="Cytoglobin-1"
FT /id="PRO_0000262320"
FT REGION 15..165
FT /note="Globin"
FT /evidence="ECO:0000255"
FT BINDING 79
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="distal binding residue"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00238"
FT BINDING 111
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="proximal binding residue"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00238"
SQ SEQUENCE 177 AA; 19989 MW; 02133B2CB3635FE9 CRC64;
MERKQGEVDH LERSRPLTDK ERVMIQDSWA KVYQNCDDAG VAILVRLFVN FPSSKQYFSQ
FKHIEDAEEL EKSSQLRKHA RRVMNAINTL VESLDNSDKV SSVLNAVGKA HAIRHKVDPV
YFKILSGVIL EVLGEAYPQV MTAEVASAWT NLLAILCCSI KAVYEELGWP HLSNSTS
