ID   CYGB2_DANRE             Reviewed;         179 AA.
AC   Q575S8;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Cytoglobin-2;
GN   Name=cygb2 {ECO:0000312|ZFIN:ZDB-GENE-060920-1};
GN   Synonyms=cygb-2 {ECO:0000312|EMBL:CAG25612.1};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:CAG25612.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX   PubMed=16199220; DOI=10.1016/j.bbrc.2005.08.271;
RA   Fuchs C., Luckhardt A., Gerlach F., Burmester T., Hankeln T.;
RT   "Duplicated cytoglobin genes in teleost fishes.";
RL   Biochem. Biophys. Res. Commun. 337:216-223(2005).
CC   -!- FUNCTION: May have a protective function during conditions of oxidative
CC       stress. May be involved in intracellular oxygen storage or transfer.
CC       {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q921A4}.
CC   -!- TISSUE SPECIFICITY: Expressed in all tissues examined, with highest
CC       levels in brain and eye, and considerably lower levels in skin, gut,
CC       heart, gill, liver and muscle. {ECO:0000269|PubMed:16199220}.
CC   -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00238}.
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DR   EMBL; AJ635229; CAG25612.1; -; mRNA.
DR   AlphaFoldDB; Q575S8; -.
DR   SMR; Q575S8; -.
DR   STRING; 7955.ENSDARP00000120009; -.
DR   PaxDb; Q575S8; -.
DR   Ensembl; ENSDART00000187763; ENSDARP00000148052; ENSDARG00000114471.
DR   Ensembl; ENSDART00000188886; ENSDARP00000152544; ENSDARG00000109892.
DR   ZFIN; ZDB-GENE-060920-1; cygb2.
DR   eggNOG; KOG3378; Eukaryota.
DR   HOGENOM; CLU_003827_10_1_1; -.
DR   InParanoid; Q575S8; -.
DR   OMA; ETQRAWT; -.
DR   PhylomeDB; Q575S8; -.
DR   TreeFam; TF332967; -.
DR   Reactome; R-DRE-203615; eNOS activation.
DR   Reactome; R-DRE-8981607; Intracellular oxygen transport.
DR   PRO; PR:Q575S8; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0098809; F:nitrite reductase activity; IDA:ZFIN.
DR   GO; GO:0019825; F:oxygen binding; IDA:ZFIN.
DR   GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.490.10; -; 1.
DR   InterPro; IPR000971; Globin.
DR   InterPro; IPR009050; Globin-like_sf.
DR   InterPro; IPR012292; Globin/Proto.
DR   InterPro; IPR013314; Globin_lamprey/hagfish.
DR   PANTHER; PTHR46783; PTHR46783; 1.
DR   Pfam; PF00042; Globin; 1.
DR   PRINTS; PR01906; FISHGLOBIN.
DR   SUPFAM; SSF46458; SSF46458; 1.
DR   PROSITE; PS01033; GLOBIN; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Heme; Iron; Metal-binding; Oxygen transport; Reference proteome;
KW   Transport.
FT   CHAIN           1..179
FT                   /note="Cytoglobin-2"
FT                   /id="PRO_0000262322"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          17..167
FT                   /note="Globin"
FT                   /evidence="ECO:0000255"
FT   BINDING         81
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="distal binding residue"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00238"
FT   BINDING         113
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="proximal binding residue"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00238"
SQ   SEQUENCE   179 AA;  20598 MW;  EF7CFE95E34D41EF CRC64;
     MEKEREDEET EGRERPEPLT DVERGIIKDT WARVYASCED VGVTILIRFF VNFPSAKQYF
     SQFQDMEDPE EMEKSSQLRK HARRVMNAIN TVVENLHDPE KVSSVLVLVG KAHAFKYKVE
     PIYFKILSGV ILEILAEEFG ECFTPEVQTS WSKLMAALYW HITGAYTEVG WVKLSSSAV