ID   CYGB2_ORYLA             Reviewed;         179 AA.
AC   Q575S9;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   28-NOV-2006, sequence version 2.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=Cytoglobin-2;
GN   Name=cygb2 {ECO:0000250|UniProtKB:Q575S8};
GN   Synonyms=cygb-2 {ECO:0000312|EMBL:CAG25611.1};
OS   Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC   Oryzias.
OX   NCBI_TaxID=8090;
RN   [1] {ECO:0000312|EMBL:CAG25611.1}
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=16199220; DOI=10.1016/j.bbrc.2005.08.271;
RA   Fuchs C., Luckhardt A., Gerlach F., Burmester T., Hankeln T.;
RT   "Duplicated cytoglobin genes in teleost fishes.";
RL   Biochem. Biophys. Res. Commun. 337:216-223(2005).
CC   -!- FUNCTION: May have a protective function during conditions of oxidative
CC       stress. May be involved in intracellular oxygen storage or transfer.
CC       {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q921A4}.
CC   -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00238}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAG25611.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AJ635228; CAG25611.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001098238.1; NM_001104768.1.
DR   STRING; 8090.ENSORLP00000000821; -.
DR   GeneID; 100049377; -.
DR   KEGG; ola:100049377; -.
DR   CTD; 554176; -.
DR   eggNOG; KOG3378; Eukaryota.
DR   InParanoid; Q575S9; -.
DR   OrthoDB; 1379813at2759; -.
DR   Proteomes; UP000001038; Unplaced.
DR   Proteomes; UP000265180; Chromosome 9.
DR   Proteomes; UP000265200; Chromosome 9.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0019825; F:oxygen binding; IEA:InterPro.
DR   GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.490.10; -; 1.
DR   InterPro; IPR000971; Globin.
DR   InterPro; IPR009050; Globin-like_sf.
DR   InterPro; IPR012292; Globin/Proto.
DR   InterPro; IPR013314; Globin_lamprey/hagfish.
DR   PANTHER; PTHR46783; PTHR46783; 1.
DR   Pfam; PF00042; Globin; 1.
DR   PRINTS; PR01906; FISHGLOBIN.
DR   SUPFAM; SSF46458; SSF46458; 1.
DR   PROSITE; PS01033; GLOBIN; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Heme; Iron; Metal-binding; Oxygen transport; Reference proteome;
KW   Transport.
FT   CHAIN           1..179
FT                   /note="Cytoglobin-2"
FT                   /id="PRO_0000262321"
FT   REGION          17..167
FT                   /note="Globin"
FT   BINDING         81
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="distal binding residue"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00238"
FT   BINDING         113
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="proximal binding residue"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00238"
SQ   SEQUENCE   179 AA;  20392 MW;  826C730CEA422068 CRC64;
     MLGVQRGECE DRPERAEPLS DAEMEIIQHT WGHVYKNCED VGVSVLIRFF VNFPSAKQYF
     SQFQDMQDPE EMEKSSQLRQ HARRVMNAIN TVVENLQDPE KVSSVLALVG KAHAVKHKVE
     PIYFKIXSGV MLSVLSEDFP EFFTAEVQLV WTKLMAAVYW HVTGAYTEVG WLQVSSSAV