CYGPB_GLOPU
ID CYGPB_GLOPU Reviewed; 32 AA.
AC C0HL36;
DT 25-OCT-2017, integrated into UniProtKB/Swiss-Prot.
DT 25-OCT-2017, sequence version 1.
DT 25-MAY-2022, entry version 6.
DE RecName: Full=Cyclotide glopa B {ECO:0000303|PubMed:19879608};
OS Gloeospermum pauciflorum.
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Malpighiales; Violaceae; Gloeospermum.
OX NCBI_TaxID=685569 {ECO:0000303|PubMed:19879608};
RN [1] {ECO:0000305}
RP PROTEIN SEQUENCE, MASS SPECTROMETRY, IDENTIFICATION BY MASS SPECTROMETRY,
RP CYCLIZATION, AND PRESENCE OF DISULFIDE BONDS.
RC TISSUE=Leaf {ECO:0000303|PubMed:19879608};
RX PubMed=19879608; DOI=10.1016/j.phytochem.2009.09.023;
RA Burman R., Gruber C.W., Rizzardi K., Herrmann A., Craik D.J., Gupta M.P.,
RA Goransson U.;
RT "Cyclotide proteins and precursors from the genus Gloeospermum: filling a
RT blank spot in the cyclotide map of Violaceae.";
RL Phytochemistry 71:13-20(2010).
CC -!- FUNCTION: Probably participates in a plant defense mechanism.
CC {ECO:0000255|PROSITE-ProRule:PRU00395}.
CC -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC structurally defines this protein as a knottin. {ECO:0000305}.
CC -!- PTM: This is a cyclic peptide. {ECO:0000255|PROSITE-ProRule:PRU00395,
CC ECO:0000269|PubMed:19879608}.
CC -!- MASS SPECTROMETRY: Mass=3373; Method=Electrospray;
CC Evidence={ECO:0000269|PubMed:19879608};
CC -!- SIMILARITY: Belongs to the cyclotide family. Bracelet subfamily.
CC {ECO:0000305|PubMed:19879608}.
CC -!- CAUTION: This peptide is cyclic. The start position was chosen by
CC similarity to Voc2 (cycloviolacin-O11) for which the DNA sequence is
CC known. {ECO:0000305}.
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DR AlphaFoldDB; C0HL36; -.
DR SMR; C0HL36; -.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR InterPro; IPR005535; Cyclotide.
DR Pfam; PF03784; Cyclotide; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Disulfide bond; Knottin; Plant defense.
FT PEPTIDE 1..32
FT /note="Cyclotide glopa B"
FT /evidence="ECO:0000269|PubMed:19879608"
FT /id="PRO_0000441839"
FT DISULFID 6..21
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00395"
FT DISULFID 10..23
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00395"
FT DISULFID 15..29
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00395"
FT CROSSLNK 1..32
FT /note="Cyclopeptide (Gly-Asn)"
FT /evidence="ECO:0000303|PubMed:19879608"
SQ SEQUENCE 32 AA; 3399 MW; 4275C64B764ABCCC CRC64;
GGSVPCIETC VWTGCFLVPG CSCKSDKKCY LN