ID   CYHR1_BOVIN             Reviewed;         311 AA.
AC   Q7YR89; Q3SX19; Q7YR91; Q7YRA6; Q8MK42;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 2.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Cysteine and histidine-rich protein 1;
GN   Name=CYHR1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND ALTERNATIVE SPLICING.
RX   PubMed=14667821; DOI=10.1016/s0888-7543(03)00238-6;
RA   Winter A., Alzinger A., Fries R.;
RT   "Assessment of the gene content of the chromosomal regions flanking bovine
RT   DGAT1.";
RL   Genomics 83:172-180(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford;
RX   PubMed=19390049; DOI=10.1126/science.1169588;
RG   The bovine genome sequencing and analysis consortium;
RT   "The genome sequence of taurine cattle: a window to ruminant biology and
RT   evolution.";
RL   Science 324:522-528(2009).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   STRAIN=Hereford; TISSUE=Uterus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 32-311.
RA   Craig J.A., Sharma B.S., Jiang Z.;
RT   "The sequence of the bovine cysteine- and histidine-rich cytoplasmic gene:
RT   EST puzzle solving by comparative assembly and confirmation by genomic
RT   sequencing.";
RL   J. Anim. Breed. Genet. 120:210-215(2003).
CC   -!- SUBUNIT: Interacts with LGALS3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear
CC       region {ECO:0000250}. Note=Shows a prominent perinuclear and
CC       cytoplasmic localization. {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q7YR89-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q7YR89-2; Sequence=VSP_032817;
CC   -!- SIMILARITY: Belongs to the CYHR1 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAM89496.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=CAD58789.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=CAD58806.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AJ518952; CAD58789.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AJ518967; CAD58804.1; -; Genomic_DNA.
DR   EMBL; AJ518969; CAD58806.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AAFC03123630; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAFC03126621; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAFC03128213; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC104552; AAI04553.1; -; mRNA.
DR   EMBL; AY129504; AAM89496.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AY129503; AAM89496.1; JOINED; Genomic_DNA.
DR   RefSeq; NP_001309753.1; NM_001322824.1. [Q7YR89-2]
DR   AlphaFoldDB; Q7YR89; -.
DR   STRING; 9913.ENSBTAP00000037191; -.
DR   PaxDb; Q7YR89; -.
DR   PRIDE; Q7YR89; -.
DR   Ensembl; ENSBTAT00000037358; ENSBTAP00000037191; ENSBTAG00000035254. [Q7YR89-1]
DR   GeneID; 282612; -.
DR   KEGG; bta:282612; -.
DR   CTD; 50626; -.
DR   VEuPathDB; HostDB:ENSBTAG00000035254; -.
DR   eggNOG; KOG3002; Eukaryota.
DR   GeneTree; ENSGT00390000018258; -.
DR   HOGENOM; CLU_035849_0_0_1; -.
DR   InParanoid; Q7YR89; -.
DR   OrthoDB; 1174688at2759; -.
DR   TreeFam; TF324281; -.
DR   Proteomes; UP000009136; Chromosome 14.
DR   Bgee; ENSBTAG00000035254; Expressed in laryngeal cartilage and 104 other tissues.
DR   ExpressionAtlas; Q7YR89; baseline.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   InterPro; IPR039338; CYHR1.
DR   PANTHER; PTHR23059; PTHR23059; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Cytoplasm; Metal-binding; Reference proteome; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..311
FT                   /note="Cysteine and histidine-rich protein 1"
FT                   /id="PRO_0000328851"
FT   ZN_FING         17..63
FT                   /note="RING-type; degenerate"
FT   ZN_FING         59..132
FT                   /note="TRAF-type"
FT   VAR_SEQ         32..311
FT                   /note="CTNGHLMCAGCFIHLLADARLKEEQATCPNCRCEISKSLCCRNLAVEKAVSE
FT                   LPSECGFCLCQFPRSILERHQKEECQDRVTQCKYKRIGCPWHGPFHELTVHEAACAHPT
FT                   KTGNELMEILDEMDQSHRKEMQLYNSIFSLLSFEKIGYTEVQFRPYRTDDFITRLYYET
FT                   PRFTVLNQTWVLKARVNDSERNPNLSCKRTLSFQLLLKSKVTAPLECSFLLLKGPYDDV
FT                   KISPVIYHFVFTNESNETDYVPLPIVDSVECNKLLAAKNINLRLFLFQIQK -> ANRG
FT                   AAAGFLLQALATATMLASGLGTDEDCLAGAWVATVIGLPLLAFDFHWVNGDCSSANLLL
FT                   GGGMVLAVAGDHLGAEGRSVAGQAVVLVVAVTILIVAVFTTNSYGMWGGVMLGAAGLLS
FT                   RLEEDRLMLLLPKEDICRWALAGGSWAYHRALHTQRLQWE (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.3"
FT                   /id="VSP_032817"
SQ   SEQUENCE   311 AA;  35489 MW;  64399EA6CDA93376 CRC64;
     MTPRPGGEWS SALSHLALGA VSLHAALSTA QCTNGHLMCA GCFIHLLADA RLKEEQATCP
     NCRCEISKSL CCRNLAVEKA VSELPSECGF CLCQFPRSIL ERHQKEECQD RVTQCKYKRI
     GCPWHGPFHE LTVHEAACAH PTKTGNELME ILDEMDQSHR KEMQLYNSIF SLLSFEKIGY
     TEVQFRPYRT DDFITRLYYE TPRFTVLNQT WVLKARVNDS ERNPNLSCKR TLSFQLLLKS
     KVTAPLECSF LLLKGPYDDV KISPVIYHFV FTNESNETDY VPLPIVDSVE CNKLLAAKNI
     NLRLFLFQIQ K