CYHR1_DROME
ID CYHR1_DROME Reviewed; 412 AA.
AC Q9VZV5; Q960J5;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 2.
DT 03-AUG-2022, entry version 159.
DE RecName: Full=Cysteine and histidine-rich protein 1 homolog;
GN ORFNames=CG32486;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
CC -!- SIMILARITY: Belongs to the CYHR1 family. {ECO:0000305}.
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DR EMBL; AE014296; AAF47711.2; -; Genomic_DNA.
DR EMBL; AY052026; AAK93450.1; -; mRNA.
DR RefSeq; NP_647765.1; NM_139508.3.
DR AlphaFoldDB; Q9VZV5; -.
DR BioGRID; 63866; 15.
DR DIP; DIP-21068N; -.
DR IntAct; Q9VZV5; 8.
DR STRING; 7227.FBpp0072874; -.
DR PaxDb; Q9VZV5; -.
DR PRIDE; Q9VZV5; -.
DR DNASU; 38367; -.
DR EnsemblMetazoa; FBtr0073004; FBpp0072874; FBgn0266918.
DR GeneID; 38367; -.
DR KEGG; dme:Dmel_CG32486; -.
DR UCSC; CG32486-RD; d. melanogaster.
DR FlyBase; FBgn0266918; CG32486.
DR VEuPathDB; VectorBase:FBgn0266918; -.
DR eggNOG; KOG3002; Eukaryota.
DR GeneTree; ENSGT00390000018258; -.
DR HOGENOM; CLU_035849_0_1_1; -.
DR InParanoid; Q9VZV5; -.
DR OMA; TNEHERN; -.
DR OrthoDB; 1174688at2759; -.
DR PhylomeDB; Q9VZV5; -.
DR BioGRID-ORCS; 38367; 0 hits in 1 CRISPR screen.
DR ChiTaRS; CG32486; fly.
DR GenomeRNAi; 38367; -.
DR PRO; PR:Q9VZV5; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0266918; Expressed in brain and 45 other tissues.
DR Genevisible; Q9VZV5; DM.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR Gene3D; 3.30.40.10; -; 2.
DR InterPro; IPR039338; CYHR1.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR001293; Znf_TRAF.
DR PANTHER; PTHR23059; PTHR23059; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
DR PROSITE; PS50145; ZF_TRAF; 1.
PE 2: Evidence at transcript level;
KW Metal-binding; Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..412
FT /note="Cysteine and histidine-rich protein 1 homolog"
FT /id="PRO_0000328858"
FT ZN_FING 113..158
FT /note="RING-type; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT ZN_FING 171..227
FT /note="TRAF-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00207"
FT REGION 1..85
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..52
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 412 AA; 45395 MW; 6C8DD9B272ACCF16 CRC64;
MSVESSSSAV QQPPSSSNLP LLGDNQAVAT TSSASSASSS STSSSSSSVG GGNVVGVPLD
TQGSGEPPAK KQLLDGGGGG ATSSSGSSLL SSAAAASGMH EKLAHRISNA LCCAVCLDLP
KTAMYQCQMG HLMCAACFTH LLADGRLRDQ IATCPNCRVE ISKSTASRNL AVEKAASELP
SECQFCNKEF PYKSLERHEQ HECQERPTKC KYHRIGCQWR GPYHETNEHE RNCLHPQKSG
YEVMAALEAH DDRIKEEKKM FNTLIDLLSY EKIIFNDLQM KPYRTDEYVH KLFYETARFS
AFNQQWVVKA RINNSQRDPH QSNERTITYQ LILKTKTSTP MSIHFFALKG PFSDMKVSTQ
IYKHEFTETS TESEYYVLPL PDGVGGSGSS ECNRMLANKG INFRLLMFLL NK
