CYHR1_HUMAN
ID CYHR1_HUMAN Reviewed; 362 AA.
AC Q6ZMK1; B3KSX0; D3DWM3; Q9BSF6; Q9BSU6;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 08-APR-2008, sequence version 2.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Cysteine and histidine-rich protein 1;
GN Name=CYHR1; Synonyms=KIAA0496;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
RC TISSUE=Brain;
RX PubMed=9455484; DOI=10.1093/dnares/4.5.345;
RA Seki N., Ohira M., Nagase T., Ishikawa K., Miyajima N., Nakajima D.,
RA Nomura N., Ohara O.;
RT "Characterization of cDNA clones in size-fractionated cDNA libraries from
RT human brain.";
RL DNA Res. 4:345-349(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Brain cortex, and Spleen;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 85-362 (ISOFORM 1).
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBUNIT: Interacts with LGALS3. {ECO:0000250}.
CC -!- INTERACTION:
CC Q6ZMK1; O00629: KPNA4; NbExp=3; IntAct=EBI-3908824, EBI-396343;
CC Q6ZMK1-3; P49639: HOXA1; NbExp=3; IntAct=EBI-11997340, EBI-740785;
CC Q6ZMK1-3; O00505: KPNA3; NbExp=3; IntAct=EBI-11997340, EBI-358297;
CC Q6ZMK1-3; Q07627: KRTAP1-1; NbExp=3; IntAct=EBI-11997340, EBI-11959885;
CC Q6ZMK1-3; Q8IUG1: KRTAP1-3; NbExp=3; IntAct=EBI-11997340, EBI-11749135;
CC Q6ZMK1-3; P0DPK4: NOTCH2NLC; NbExp=3; IntAct=EBI-11997340, EBI-22310682;
CC Q6ZMK1-3; P15151: PVR; NbExp=3; IntAct=EBI-11997340, EBI-3919694;
CC Q6ZMK1-3; O00560: SDCBP; NbExp=3; IntAct=EBI-11997340, EBI-727004;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear
CC region {ECO:0000250}. Note=Shows a prominent perinuclear and
CC cytoplasmic localization. {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q6ZMK1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6ZMK1-2; Sequence=VSP_032818;
CC Name=3;
CC IsoId=Q6ZMK1-3; Sequence=VSP_032819;
CC Name=4;
CC IsoId=Q6ZMK1-4; Sequence=VSP_032818, VSP_032820;
CC -!- SIMILARITY: Belongs to the CYHR1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAD18724.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB007965; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AK094514; BAG52882.1; -; mRNA.
DR EMBL; AK160381; BAD18724.1; ALT_INIT; mRNA.
DR EMBL; CH471162; EAW82088.1; -; Genomic_DNA.
DR EMBL; CH471162; EAW82089.1; -; Genomic_DNA.
DR EMBL; CH471162; EAW82091.1; -; Genomic_DNA.
DR EMBL; BC004544; AAH04544.2; -; mRNA.
DR EMBL; BC005073; AAH05073.1; -; mRNA.
DR EMBL; BC065484; AAH65484.1; -; mRNA.
DR RefSeq; NP_001123360.1; NM_001129888.1. [Q6ZMK1-3]
DR RefSeq; NP_001317547.1; NM_001330618.1.
DR RefSeq; NP_116076.1; NM_032687.3. [Q6ZMK1-3]
DR RefSeq; NP_612505.1; NM_138496.1. [Q6ZMK1-1]
DR RefSeq; XP_006716623.1; XM_006716560.3.
DR RefSeq; XP_006716624.1; XM_006716561.3.
DR RefSeq; XP_011515353.1; XM_011517051.1.
DR AlphaFoldDB; Q6ZMK1; -.
DR BioGRID; 119101; 48.
DR IntAct; Q6ZMK1; 12.
DR MINT; Q6ZMK1; -.
DR STRING; 9606.ENSP00000387426; -.
DR CarbonylDB; Q6ZMK1; -.
DR iPTMnet; Q6ZMK1; -.
DR PhosphoSitePlus; Q6ZMK1; -.
DR BioMuta; CYHR1; -.
DR DMDM; 182641989; -.
DR EPD; Q6ZMK1; -.
DR jPOST; Q6ZMK1; -.
DR MassIVE; Q6ZMK1; -.
DR MaxQB; Q6ZMK1; -.
DR PaxDb; Q6ZMK1; -.
DR PeptideAtlas; Q6ZMK1; -.
DR PRIDE; Q6ZMK1; -.
DR ProteomicsDB; 67884; -. [Q6ZMK1-1]
DR ProteomicsDB; 67885; -. [Q6ZMK1-2]
DR ProteomicsDB; 67886; -. [Q6ZMK1-3]
DR ProteomicsDB; 67887; -. [Q6ZMK1-4]
DR Antibodypedia; 52728; 24 antibodies from 11 providers.
DR DNASU; 50626; -.
DR Ensembl; ENST00000306145.10; ENSP00000304826.5; ENSG00000187954.13. [Q6ZMK1-3]
DR Ensembl; ENST00000403000.6; ENSP00000385962.2; ENSG00000187954.13. [Q6ZMK1-3]
DR Ensembl; ENST00000424149.6; ENSP00000414647.2; ENSG00000187954.13. [Q6ZMK1-3]
DR Ensembl; ENST00000438911.6; ENSP00000387426.2; ENSG00000187954.13. [Q6ZMK1-1]
DR GeneID; 50626; -.
DR KEGG; hsa:50626; -.
DR UCSC; uc003zcv.3; human. [Q6ZMK1-1]
DR CTD; 50626; -.
DR DisGeNET; 50626; -.
DR GeneCards; CYHR1; -.
DR HGNC; HGNC:17806; CYHR1.
DR HPA; ENSG00000187954; Low tissue specificity.
DR MIM; 616635; gene.
DR neXtProt; NX_Q6ZMK1; -.
DR OpenTargets; ENSG00000187954; -.
DR PharmGKB; PA27081; -.
DR VEuPathDB; HostDB:ENSG00000187954; -.
DR eggNOG; KOG3002; Eukaryota.
DR GeneTree; ENSGT00390000018258; -.
DR InParanoid; Q6ZMK1; -.
DR OrthoDB; 1174688at2759; -.
DR PhylomeDB; Q6ZMK1; -.
DR TreeFam; TF324281; -.
DR PathwayCommons; Q6ZMK1; -.
DR SignaLink; Q6ZMK1; -.
DR BioGRID-ORCS; 50626; 29 hits in 1079 CRISPR screens.
DR ChiTaRS; CYHR1; human.
DR GenomeRNAi; 50626; -.
DR Pharos; Q6ZMK1; Tdark.
DR PRO; PR:Q6ZMK1; -.
DR Proteomes; UP000005640; Chromosome 8.
DR RNAct; Q6ZMK1; protein.
DR Bgee; ENSG00000187954; Expressed in right hemisphere of cerebellum and 177 other tissues.
DR ExpressionAtlas; Q6ZMK1; baseline and differential.
DR Genevisible; Q6ZMK1; HS.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR039338; CYHR1.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR001293; Znf_TRAF.
DR PANTHER; PTHR23059; PTHR23059; 1.
DR PROSITE; PS50145; ZF_TRAF; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cytoplasm; Metal-binding; Reference proteome; Zinc;
KW Zinc-finger.
FT CHAIN 1..362
FT /note="Cysteine and histidine-rich protein 1"
FT /id="PRO_0000328852"
FT ZN_FING 68..114
FT /note="RING-type; degenerate"
FT ZN_FING 110..183
FT /note="TRAF-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00207"
FT VAR_SEQ 1..88
FT /note="Missing (in isoform 2 and isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:9455484"
FT /id="VSP_032818"
FT VAR_SEQ 83..362
FT /note="CTNGHLMCAGCFIHLLADARLKEEQATCPNCRCEISKSLCCRNLAVEKAVSE
FT LPSECGFCLRQFPRSLLERHQKEECQDRVTQCKYKRIGCPWHGPFHELTVHEAACAHPT
FT KTGSELMEILDGMDQSHRKEMQLYNSIFSLLSFEKIGYTEVQFRPYRTDDFITRLYYET
FT PRFTVLNQTWVLKARVNDSERNPNLSCKRTLSFQLLLKSKVTAPLECSFLLLKGPYDDV
FT RISPVIYHFVFTNESNETDYVPLPIIDSVECNKLLAAKNINLRLFLFQIQK -> VNGD
FT RSSANLLLGGGMVLAVAGGHLGPEGRSVAGQAMLLVVAVTILIVAVFTANTYGMWGGAM
FT LGVAGLLSRLEEDRLLLLPKEDVCRWALAVGSWAYCRALHTQRLQWE (in isoform
FT 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_032819"
FT VAR_SEQ 233..362
FT /note="EVQFRPYRTDDFITRLYYETPRFTVLNQTWVLKARVNDSERNPNLSCKRTLS
FT FQLLLKSKVTAPLECSFLLLKGPYDDVRISPVIYHFVFTNESNETDYVPLPIIDSVECN
FT KLLAAKNINLRLFLFQIQK -> GEAPRRLLHATQVWVGGLAARSLGAAGSGHWALTAP
FT DSRALDKLPVDRWTPRSRRQAGD (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:9455484"
FT /id="VSP_032820"
SQ SEQUENCE 362 AA; 40703 MW; 2409CCF532C6C868 CRC64;
MAPKPGAEWS TALSHLVLGV VSLHAAVSTA EASRGAAAGF LLQVLAATTT LAPGLSTHED
CLAGAWVATV IGLPLLAFDF HWCTNGHLMC AGCFIHLLAD ARLKEEQATC PNCRCEISKS
LCCRNLAVEK AVSELPSECG FCLRQFPRSL LERHQKEECQ DRVTQCKYKR IGCPWHGPFH
ELTVHEAACA HPTKTGSELM EILDGMDQSH RKEMQLYNSI FSLLSFEKIG YTEVQFRPYR
TDDFITRLYY ETPRFTVLNQ TWVLKARVND SERNPNLSCK RTLSFQLLLK SKVTAPLECS
FLLLKGPYDD VRISPVIYHF VFTNESNETD YVPLPIIDSV ECNKLLAAKN INLRLFLFQI
QK
