CYK3_SCHPO
ID CYK3_SCHPO Reviewed; 886 AA.
AC O14302;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=cytokinesis protein 3;
GN Name=cyk3; ORFNames=SPAC9G1.06c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-213, AND IDENTIFICATION BY
RP MASS SPECTROMETRY.
RX PubMed=18257517; DOI=10.1021/pr7006335;
RA Wilson-Grady J.T., Villen J., Gygi S.P.;
RT "Phosphoproteome analysis of fission yeast.";
RL J. Proteome Res. 7:1088-1097(2008).
CC -!- FUNCTION: Involved in cytokinesis. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell tip {ECO:0000269|PubMed:16823372}. Cell
CC septum {ECO:0000269|PubMed:16823372}.
CC -!- SIMILARITY: Belongs to the CYK3 family. {ECO:0000305}.
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DR EMBL; CU329670; CAB11490.1; -; Genomic_DNA.
DR PIR; T39229; T39229.
DR RefSeq; NP_593561.1; NM_001018994.2.
DR AlphaFoldDB; O14302; -.
DR BioGRID; 279190; 48.
DR STRING; 4896.SPAC9G1.06c.1; -.
DR iPTMnet; O14302; -.
DR MaxQB; O14302; -.
DR PaxDb; O14302; -.
DR PRIDE; O14302; -.
DR EnsemblFungi; SPAC9G1.06c.1; SPAC9G1.06c.1:pep; SPAC9G1.06c.
DR GeneID; 2542740; -.
DR KEGG; spo:SPAC9G1.06c; -.
DR PomBase; SPAC9G1.06c; cyk3.
DR VEuPathDB; FungiDB:SPAC9G1.06c; -.
DR eggNOG; KOG4575; Eukaryota.
DR HOGENOM; CLU_008674_1_0_1; -.
DR InParanoid; O14302; -.
DR OMA; CTPYELT; -.
DR PhylomeDB; O14302; -.
DR PRO; PR:O14302; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0051285; C:cell cortex of cell tip; IDA:PomBase.
DR GO; GO:0140472; C:cell cortex of non-growing cell tip; IDA:PomBase.
DR GO; GO:0032153; C:cell division site; HDA:PomBase.
DR GO; GO:0009986; C:cell surface; IDA:PomBase.
DR GO; GO:0051286; C:cell tip; HDA:PomBase.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0000935; C:division septum; IDA:PomBase.
DR GO; GO:0110085; C:mitotic actomyosin contractile ring; IDA:PomBase.
DR GO; GO:0120105; C:mitotic actomyosin contractile ring, intermediate layer; IDA:PomBase.
DR GO; GO:1902404; P:mitotic actomyosin contractile ring contraction; IMP:PomBase.
DR GO; GO:0140278; P:mitotic division septum assembly; IMP:PomBase.
DR CDD; cd11889; SH3_Cyk3p-like; 1.
DR InterPro; IPR035553; Cyk3_SH3.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR002931; Transglutaminase-like.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00326; SH3; 1.
DR SMART; SM00460; TGc; 1.
DR SUPFAM; SSF50044; SSF50044; 1.
DR SUPFAM; SSF54001; SSF54001; 1.
DR PROSITE; PS50002; SH3; 1.
PE 1: Evidence at protein level;
KW Cell cycle; Cell division; Phosphoprotein; Reference proteome; SH3 domain.
FT CHAIN 1..886
FT /note="cytokinesis protein 3"
FT /id="PRO_0000116705"
FT DOMAIN 6..67
FT /note="SH3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT REGION 72..189
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 219..290
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 358..393
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 72..120
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 130..189
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 237..290
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 213
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
SQ SEQUENCE 886 AA; 98263 MW; D0C4879C1882E869 CRC64;
MSIPKQLPCM VRALYAWPGE REGDLKFTEG DLIECLSIGD GKWWIGRHIN TNTQGIFPSN
FVHCLDIPTV RPGSSMSRTS ASSFRYSSPQ KSSIDTPITS SDQGLTPDLV GSSNALNKPT
RESDSLKHQK SHPMLNSLGS SLSLKKSVSR PPSSMSRTNL DVSSRWDNTA DNDSQIDAQD
LSRSTPSPLR SAMENVLQSL NAMGKKSFSR ANSPLLRLTK STTTSKETDF IPVPPAHGST
SMTSRSKLDD STDNSSKPRT SLQPGESPMK SSRDISRKPS MASSVLSPSD YFPQHRRFQS
APAPIPRPVS TLIPLTQVRT TASNVIKPRP QTTERPSTAQ SFRKGGGFLK KTFKKLLRRG
SSKRKPSLQP TPPVSYPAHN VPQKGVRPAS PHTLKSVKDD LKRTKTYTKA EFAAKREEIF
NKLSMPVYEP LKDLSECIGN VLADGEPVQF SVGTNIHNMN FSAIDKQIRS IIPQRVQVSP
AVLAKNYLAP GQTTALAQMR AVFIYISERI TFTNQTLDND ELRTSTQVIS EGQGTPFEVA
LLVKEMLQAL DLWCEVIEGY LKSPDDIYYT RDININHAWN VVTFDNEVRL IDASFASPTH
PQQALKSSSS NDFYFLMKPN ECIFTHVPEN PDQQFIMPDL SMPIVMALPW VSSVYFTLGL
KLRKFNTSIL HLNDLEVLQI EFLAPKDIEC VAEVDALSAL APTADVSQCY KYTLTQAFWE
TPDIRVMRVK AVMPANNRAA VLRIYAGRLG VSSPVRTAPH PMAMSLPFVH HGKNKALEFV
TRHPVPHCPS VDLYINSPQC GTLHSGVEYK FNVSAYACQP STSISNTRLA IQTPTGNIVR
LREERSGNGV IFFSLSLTIN ETGEYRALIL AEKIGRWVVY ATWQAV
