CYL1_ARATH
ID CYL1_ARATH Reviewed; 255 AA.
AC Q93V74; O49487;
DT 25-APR-2018, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 25-MAY-2022, entry version 118.
DE RecName: Full=Cyclase-like protein 1 {ECO:0000305};
DE Flags: Precursor;
GN Name=CYCLASE1 {ECO:0000303|PubMed:25862728};
GN OrderedLocusNames=At4g34180 {ECO:0000312|Araport:AT4G34180};
GN ORFNames=F10M10.6 {ECO:0000312|EMBL:AEE86337.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP FUNCTION, IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION,
RP INDUCTION BY SALICYLATE, DISRUPTION PHENOTYPE, GENE FAMILY, AND
RP NOMENCLATURE.
RX PubMed=25862728; DOI=10.1074/mcp.m114.045054;
RA Smith S.J., Kroon J.T., Simon W.J., Slabas A.R., Chivasa S.;
RT "A novel function for Arabidopsis CYCLASE1 in programmed cell death
RT revealed by isobaric tags for relative and absolute quantitation (iTRAQ)
RT analysis of extracellular matrix proteins.";
RL Mol. Cell. Proteomics 14:1556-1568(2015).
CC -!- FUNCTION: Acts as a negative regulator of fumonisin B1- and pathogen-
CC induced programmed cell death (PCD), and regulates pathogen-induced
CC symptom development (PubMed:25862728). May function redundantly with
CC CYCLASE2 for normal plant growth, development and viability (Probable).
CC {ECO:0000269|PubMed:25862728, ECO:0000305|PubMed:25862728}.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000269|PubMed:25862728}.
CC -!- INDUCTION: Induced by salicylate. {ECO:0000269|PubMed:25862728}.
CC -!- DISRUPTION PHENOTYPE: No visible phenotype under normal growth
CC conditions, but leaves of mutant plants exhibit a severly increased
CC cell death when exposed to fumonisin B1 or a bacterial pathogen that
CC triggers the defensive hypersensitive cell death. The double mutants
CC cyclase1 and cyclase2 are embryonic lethal.
CC {ECO:0000269|PubMed:25862728}.
CC -!- SIMILARITY: Belongs to the Cyclase 1 superfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA17554.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAB80135.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AL021961; CAA17554.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL161585; CAB80135.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002687; AEE86337.1; -; Genomic_DNA.
DR EMBL; AF428442; AAL16211.1; -; mRNA.
DR EMBL; AY037228; AAK59828.1; -; mRNA.
DR EMBL; AY125547; AAM78057.1; -; mRNA.
DR EMBL; AY088629; AAM66951.1; -; mRNA.
DR PIR; T05418; T05418.
DR RefSeq; NP_567957.1; NM_119581.4.
DR AlphaFoldDB; Q93V74; -.
DR SMR; Q93V74; -.
DR STRING; 3702.AT4G34180.1; -.
DR MetOSite; Q93V74; -.
DR SwissPalm; Q93V74; -.
DR PaxDb; Q93V74; -.
DR PRIDE; Q93V74; -.
DR ProteomicsDB; 222739; -.
DR EnsemblPlants; AT4G34180.1; AT4G34180.1; AT4G34180.
DR GeneID; 829566; -.
DR Gramene; AT4G34180.1; AT4G34180.1; AT4G34180.
DR KEGG; ath:AT4G34180; -.
DR Araport; AT4G34180; -.
DR TAIR; locus:2124231; AT4G34180.
DR eggNOG; ENOG502QRBQ; Eukaryota.
DR HOGENOM; CLU_030671_4_1_1; -.
DR InParanoid; Q93V74; -.
DR OMA; DTPRNKN; -.
DR OrthoDB; 1264549at2759; -.
DR PhylomeDB; Q93V74; -.
DR PRO; PR:Q93V74; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; Q93V74; baseline and differential.
DR GO; GO:0005783; C:endoplasmic reticulum; HDA:TAIR.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0005794; C:Golgi apparatus; HDA:TAIR.
DR GO; GO:0005886; C:plasma membrane; HDA:TAIR.
DR GO; GO:0099503; C:secretory vesicle; HDA:TAIR.
DR GO; GO:0004061; F:arylformamidase activity; IBA:GO_Central.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0043069; P:negative regulation of programmed cell death; IMP:TAIR.
DR GO; GO:0019441; P:tryptophan catabolic process to kynurenine; IBA:GO_Central.
DR Gene3D; 3.50.30.50; -; 1.
DR InterPro; IPR007325; KFase/CYL.
DR InterPro; IPR037175; KFase_sf.
DR PANTHER; PTHR31118; PTHR31118; 1.
DR Pfam; PF04199; Cyclase; 1.
DR SUPFAM; SSF102198; SSF102198; 1.
PE 1: Evidence at protein level;
KW Extracellular matrix; Plant defense; Reference proteome; Secreted; Signal.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..255
FT /note="Cyclase-like protein 1"
FT /id="PRO_5011950512"
SQ SEQUENCE 255 AA; 28385 MW; E9DB5E20FF842BC7 CRC64;
MTRSVSFPLF LFAVVLSLSS SLLADDPKPI RREVYEGGKI YDISHRYTPE IPAWESSEGL
GKTFLRLAAS MKNGSFANVS EMKLSVHSGT HVDAPGHFWD NYYDAGFDTD SLDLQVLNGP
ALLVDVPRDK NITAEVMESL HIQRGVRRVL FRTSNTDKRL MFKKEFDSSF AGFMTDGAKW
LVENTDIKLI GLDYLSFAAF EESPATHRVI LKGRDIIPVE ALKLDGVEVG TYSLHCLPLR
LVGAEGAPTR CILIK
