CYL2_ARATH
ID CYL2_ARATH Reviewed; 272 AA.
AC Q94JT5; O65505;
DT 25-APR-2018, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 25-MAY-2022, entry version 114.
DE RecName: Full=Cyclase-like protein 2 {ECO:0000305};
DE Flags: Precursor;
GN Name=CYCLASE2 {ECO:0000303|PubMed:25862728};
GN OrderedLocusNames=At4g35220 {ECO:0000312|Araport:AT4G35220};
GN ORFNames=F23E12.220 {ECO:0000312|EMBL:CAA18747.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP FUNCTION, DISRUPTION PHENOTYPE, GENE FAMILY, AND NOMENCLATURE.
RX PubMed=25862728; DOI=10.1074/mcp.m114.045054;
RA Smith S.J., Kroon J.T., Simon W.J., Slabas A.R., Chivasa S.;
RT "A novel function for Arabidopsis CYCLASE1 in programmed cell death
RT revealed by isobaric tags for relative and absolute quantitation (iTRAQ)
RT analysis of extracellular matrix proteins.";
RL Mol. Cell. Proteomics 14:1556-1568(2015).
CC -!- FUNCTION: May function redundantly with CYCLASE1 for normal plant
CC growth, development and viability. {ECO:0000305|PubMed:25862728}.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000250|UniProtKB:Q93V74}.
CC -!- DISRUPTION PHENOTYPE: No visible phenotype under normal growth
CC conditions, but the double mutants cyclase1 and cyclase2 are embryonic
CC lethal. {ECO:0000269|PubMed:25862728}.
CC -!- SIMILARITY: Belongs to the Cyclase 1 superfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA18747.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAB80239.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AL022604; CAA18747.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL161587; CAB80239.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002687; AEE86481.1; -; Genomic_DNA.
DR EMBL; AF372956; AAK50095.1; -; mRNA.
DR EMBL; AY074834; AAL69532.1; -; mRNA.
DR EMBL; AY085190; AAM61741.1; -; mRNA.
DR PIR; T06135; T06135.
DR RefSeq; NP_567979.1; NM_119688.4.
DR AlphaFoldDB; Q94JT5; -.
DR SMR; Q94JT5; -.
DR STRING; 3702.AT4G35220.1; -.
DR PaxDb; Q94JT5; -.
DR PRIDE; Q94JT5; -.
DR ProteomicsDB; 224690; -.
DR EnsemblPlants; AT4G35220.1; AT4G35220.1; AT4G35220.
DR GeneID; 829675; -.
DR Gramene; AT4G35220.1; AT4G35220.1; AT4G35220.
DR KEGG; ath:AT4G35220; -.
DR Araport; AT4G35220; -.
DR TAIR; locus:2122053; AT4G35220.
DR eggNOG; ENOG502QRBQ; Eukaryota.
DR HOGENOM; CLU_030671_4_1_1; -.
DR InParanoid; Q94JT5; -.
DR OMA; GHPTHKT; -.
DR OrthoDB; 1264549at2759; -.
DR PhylomeDB; Q94JT5; -.
DR PRO; PR:Q94JT5; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; Q94JT5; baseline and differential.
DR GO; GO:0005783; C:endoplasmic reticulum; HDA:TAIR.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0005794; C:Golgi apparatus; HDA:TAIR.
DR GO; GO:0005886; C:plasma membrane; HDA:TAIR.
DR GO; GO:0099503; C:secretory vesicle; HDA:TAIR.
DR GO; GO:0004061; F:arylformamidase activity; IBA:GO_Central.
DR GO; GO:0019441; P:tryptophan catabolic process to kynurenine; IBA:GO_Central.
DR Gene3D; 3.50.30.50; -; 1.
DR InterPro; IPR007325; KFase/CYL.
DR InterPro; IPR037175; KFase_sf.
DR PANTHER; PTHR31118; PTHR31118; 1.
DR Pfam; PF04199; Cyclase; 1.
DR SUPFAM; SSF102198; SSF102198; 1.
PE 2: Evidence at transcript level;
KW Extracellular matrix; Reference proteome; Secreted; Signal.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..272
FT /note="Cyclase-like protein 2"
FT /id="PRO_5011950584"
SQ SEQUENCE 272 AA; 29988 MW; B2CF071A8C378B35 CRC64;
MAVPPLFFLL TLLSLPSLLI SAGASNAYPS IPGTAPIDGG FTDELKPIRR EVYGNGKIYD
ISHRYTPEMP SWDSSEGIGR FLWLAASMKN GSLANNSEMK IPTHTGTHVD SPGHVYDKYY
DAGFDVDSLD LQVLNGLALL VDVPKDKNIT AEVMKSLHIP KGVSRVLFRT LNTDRRLMFK
KEFDTSYVGF MKDGAQWLVD NTDIKLVGID YLSVAAYDDL IPSHLVFLKD RETILVEGLK
LDGVKAGLYS VHCLPLRLVG AEGSPIRCIL ID
