CYL3_ARATH
ID CYL3_ARATH Reviewed; 271 AA.
AC Q94LA9;
DT 25-APR-2018, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 25-MAY-2022, entry version 125.
DE RecName: Full=Cyclase-like protein 3 {ECO:0000305};
DE Flags: Precursor;
GN Name=CYCLASE3 {ECO:0000303|PubMed:25862728};
GN OrderedLocusNames=At1g44542 {ECO:0000312|Araport:AT1G44542};
GN ORFNames=T18F15.4 {ECO:0000312|EMBL:AAK43483.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Shinn P., Chen H., Cheuk R., Kim C.J., Carninci P., Hayashizaki Y.,
RA Ishida J., Kamiya A., Kawai J., Narusaka M., Sakurai T., Satou M., Seki M.,
RA Shinozaki K., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=25862728; DOI=10.1074/mcp.m114.045054;
RA Smith S.J., Kroon J.T., Simon W.J., Slabas A.R., Chivasa S.;
RT "A novel function for Arabidopsis CYCLASE1 in programmed cell death
RT revealed by isobaric tags for relative and absolute quantitation (iTRAQ)
RT analysis of extracellular matrix proteins.";
RL Mol. Cell. Proteomics 14:1556-1568(2015).
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000250|UniProtKB:Q93V74}.
CC -!- SIMILARITY: Belongs to the Cyclase 1 superfamily. {ECO:0000305}.
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DR EMBL; AC084807; AAK43483.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE32038.1; -; Genomic_DNA.
DR EMBL; BT012646; AAT06465.1; -; mRNA.
DR EMBL; AK220578; BAD94854.1; -; mRNA.
DR RefSeq; NP_175091.1; NM_103551.3.
DR AlphaFoldDB; Q94LA9; -.
DR SMR; Q94LA9; -.
DR STRING; 3702.AT1G44542.1; -.
DR PaxDb; Q94LA9; -.
DR PRIDE; Q94LA9; -.
DR ProteomicsDB; 224694; -.
DR EnsemblPlants; AT1G44542.1; AT1G44542.1; AT1G44542.
DR GeneID; 841032; -.
DR Gramene; AT1G44542.1; AT1G44542.1; AT1G44542.
DR KEGG; ath:AT1G44542; -.
DR Araport; AT1G44542; -.
DR TAIR; locus:2823650; AT1G44542.
DR eggNOG; ENOG502QRBQ; Eukaryota.
DR HOGENOM; CLU_030671_4_1_1; -.
DR InParanoid; Q94LA9; -.
DR OMA; NGSMANE; -.
DR OrthoDB; 1264549at2759; -.
DR PhylomeDB; Q94LA9; -.
DR PRO; PR:Q94LA9; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q94LA9; baseline and differential.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; HDA:TAIR.
DR GO; GO:0004061; F:arylformamidase activity; IBA:GO_Central.
DR GO; GO:0019441; P:tryptophan catabolic process to kynurenine; IBA:GO_Central.
DR Gene3D; 3.50.30.50; -; 1.
DR InterPro; IPR007325; KFase/CYL.
DR InterPro; IPR037175; KFase_sf.
DR PANTHER; PTHR31118; PTHR31118; 1.
DR Pfam; PF04199; Cyclase; 1.
DR SUPFAM; SSF102198; SSF102198; 1.
PE 2: Evidence at transcript level;
KW Extracellular matrix; Reference proteome; Secreted; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..271
FT /note="Cyclase-like protein 3"
FT /id="PRO_5011950592"
SQ SEQUENCE 271 AA; 30636 MW; 871911F62A9AB110 CRC64;
MYHLLIIITT LSFSSINITF AVDEAFPSIP TTFSVATKQH YDVKPIHHEV YDGERKIYDI
SHQYTPELPV WESSEGLGNF LRLAVSMKNG SDANISKMEL SVHSGTHVDA PGHFHDHYYE
SGFDTDSLDL QILNGPALLV DVPRDKNISA EVMKSLHIPR GIRRVLFKTL NTDRRLMFKK
EFDSSFVGFM VDGAKWLVEN TDIKLVGLDY LSFAAYDEAP ATHRFILERR DIIPVEALKL
DDVEVGMYTL HCLPLRLVGA EGAPTRCILI K
