ID   CYLC1_BOVIN             Reviewed;         667 AA.
AC   P35662;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=Cylicin-1;
DE   AltName: Full=Cylicin I;
DE   AltName: Full=Multiple-band polypeptide I;
GN   Name=CYLC1; Synonyms=CYL, CYL1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE.
RC   TISSUE=Testis;
RX   PubMed=8354692; DOI=10.1083/jcb.122.5.1043;
RA   Hess H., Heid H., Franke W.W.;
RT   "Molecular characterization of mammalian cylicin, a basic protein of the
RT   sperm head cytoskeleton.";
RL   J. Cell Biol. 122:1043-1052(1993).
CC   -!- FUNCTION: Possible architectural role during spermatogenesis. May be
CC       involved in spermatid differentiation.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, perinuclear theca,
CC       calyx. Note=Sperm head cytoskeletal structure.
CC   -!- TISSUE SPECIFICITY: Testis.
CC   -!- DEVELOPMENTAL STAGE: Specific to late spermatogenesis.
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DR   EMBL; Z22779; CAA80456.1; -; mRNA.
DR   PIR; A40713; A40713.
DR   RefSeq; NP_776727.1; NM_174302.3.
DR   AlphaFoldDB; P35662; -.
DR   STRING; 9913.ENSBTAP00000054504; -.
DR   PaxDb; P35662; -.
DR   GeneID; 281737; -.
DR   KEGG; bta:281737; -.
DR   CTD; 1538; -.
DR   eggNOG; ENOG502RFCV; Eukaryota.
DR   InParanoid; P35662; -.
DR   OrthoDB; 1388571at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0043159; C:acrosomal matrix; IBA:GO_Central.
DR   GO; GO:0033150; C:cytoskeletal calyx; IEA:UniProtKB-SubCell.
DR   GO; GO:0005200; F:structural constituent of cytoskeleton; IEA:InterPro.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR   InterPro; IPR026189; CYLC.
DR   InterPro; IPR029354; Cylicin_N.
DR   PANTHER; PTHR16742; PTHR16742; 2.
DR   Pfam; PF15241; Cylicin_N; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Cytoskeleton; Developmental protein; Differentiation;
KW   Direct protein sequencing; Reference proteome; Repeat; Spermatogenesis.
FT   CHAIN           1..667
FT                   /note="Cylicin-1"
FT                   /id="PRO_0000079752"
FT   REPEAT          287..305
FT                   /note="1"
FT   REPEAT          306..337
FT                   /note="2"
FT   REPEAT          338..368
FT                   /note="3"
FT   REPEAT          369..405
FT                   /note="4"
FT   REPEAT          406..442
FT                   /note="5"
FT   REPEAT          443..475
FT                   /note="6"
FT   REPEAT          476..516
FT                   /note="7"
FT   REPEAT          517..547
FT                   /note="8"
FT   REPEAT          548..569
FT                   /note="9"
FT   REGION          121..251
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          275..634
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          287..569
FT                   /note="9 X approximate tandem repeats"
FT   COMPBIAS        125..172
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        200..227
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        228..251
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        279..342
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        349..534
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        543..616
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        619..633
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   667 AA;  74817 MW;  CBF66EA462243D91 CRC64;
     MSLPRLCLGE LINEDIHTWN SLCRQEITIK TYDNSIPISE SSKKIRNQQY LTITFPKSSQ
     PGGNKRLRPS EIQVTVPRHD KRNLDELQKP AHIWIRHSLR KKFQSPSINL IVRRQASFRH
     PYTHITHSKK AESKKYKDDK KETALKKISK KDTGPHEVDE KPKRRNKADK TPSKSSHGSQ
     LSKKSKSKSE TNPESKDSIS VSIKHQKKEK RYSKDSKEMD FESTSTKKYS KSSKNNSDAV
     SETCSKNSSN VGLMVHLGES DAESMEFDMW LKNYSQNNSK KPTKKDAKKD AKGKGSDAES
     VDSKDAKKDK KGATKDTKKG AKKDTESTDA ESGDSKDAKK GKKESKKDKK KDAKKDAASD
     AESGDSKDAK KDSKKGKKDS KKDNKKKDAK KDAESTDAES GDSKDAKKDS KKGKKDSKKD
     DKKKDAKKDA ESTDAESGDS KNAKKDSKKG KKDDKKKDAK KDAVSTDADS ESEGDAKKSK
     KDSKKDKKDL KKDDQKKPAM KSKESTETES DWESKKVKRD SKKDTKKTAK KATESSGAES
     DVSSKRYLKK TEMFKSSDAE SEESLFKPGS KKRVDESDAT STDSKKDAVE PKRGIKMPSR
     RTTFKEKGKK IGTGRVPPSR ERPPLPPCEP ILPSPRVKRL CRCQMPPPPP KPRYAPLPEA
     KWIHKLL