CYLC1_HUMAN
ID CYLC1_HUMAN Reviewed; 651 AA.
AC P35663; A0AVQ8; Q5JQQ9;
DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 2.
DT 03-AUG-2022, entry version 158.
DE RecName: Full=Cylicin-1;
DE AltName: Full=Cylicin I;
DE AltName: Full=Multiple-band polypeptide I;
GN Name=CYLC1; Synonyms=CYL, CYL1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 54-651.
RC TISSUE=Testis;
RX PubMed=8354692; DOI=10.1083/jcb.122.5.1043;
RA Hess H., Heid H., Franke W.W.;
RT "Molecular characterization of mammalian cylicin, a basic protein of the
RT sperm head cytoskeleton.";
RL J. Cell Biol. 122:1043-1052(1993).
CC -!- FUNCTION: Possible architectural role during spermatogenesis. May be
CC involved in spermatid differentiation.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, perinuclear theca,
CC calyx. Note=Sperm head cytoskeletal structure.
CC -!- TISSUE SPECIFICITY: Testis.
CC -!- DEVELOPMENTAL STAGE: Specific to late spermatogenesis.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AL627233; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC126461; AAI26462.1; -; mRNA.
DR EMBL; Z22780; CAA80457.1; -; mRNA.
DR CCDS; CCDS35341.1; -.
DR PIR; B40713; B40713.
DR RefSeq; NP_066941.1; NM_021118.2.
DR AlphaFoldDB; P35663; -.
DR BioGRID; 107918; 1.
DR IntAct; P35663; 1.
DR STRING; 9606.ENSP00000331556; -.
DR CarbonylDB; P35663; -.
DR iPTMnet; P35663; -.
DR PhosphoSitePlus; P35663; -.
DR BioMuta; CYLC1; -.
DR DMDM; 77416856; -.
DR MassIVE; P35663; -.
DR MaxQB; P35663; -.
DR PaxDb; P35663; -.
DR PeptideAtlas; P35663; -.
DR PRIDE; P35663; -.
DR ProteomicsDB; 55129; -.
DR Antibodypedia; 14277; 49 antibodies from 20 providers.
DR DNASU; 1538; -.
DR Ensembl; ENST00000329312.5; ENSP00000331556.4; ENSG00000183035.13.
DR GeneID; 1538; -.
DR KEGG; hsa:1538; -.
DR MANE-Select; ENST00000329312.5; ENSP00000331556.4; NM_021118.3; NP_066941.1.
DR UCSC; uc004eei.3; human.
DR CTD; 1538; -.
DR DisGeNET; 1538; -.
DR GeneCards; CYLC1; -.
DR HGNC; HGNC:2582; CYLC1.
DR HPA; ENSG00000183035; Tissue enriched (testis).
DR MIM; 300768; gene.
DR neXtProt; NX_P35663; -.
DR OpenTargets; ENSG00000183035; -.
DR PharmGKB; PA27082; -.
DR VEuPathDB; HostDB:ENSG00000183035; -.
DR eggNOG; ENOG502RFCV; Eukaryota.
DR GeneTree; ENSGT00730000111075; -.
DR HOGENOM; CLU_480276_0_0_1; -.
DR InParanoid; P35663; -.
DR OMA; RQAPFRN; -.
DR OrthoDB; 1388571at2759; -.
DR PhylomeDB; P35663; -.
DR TreeFam; TF337809; -.
DR PathwayCommons; P35663; -.
DR SignaLink; P35663; -.
DR BioGRID-ORCS; 1538; 10 hits in 691 CRISPR screens.
DR ChiTaRS; CYLC1; human.
DR GenomeRNAi; 1538; -.
DR Pharos; P35663; Tdark.
DR PRO; PR:P35663; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; P35663; protein.
DR Bgee; ENSG00000183035; Expressed in sperm and 18 other tissues.
DR ExpressionAtlas; P35663; baseline and differential.
DR Genevisible; P35663; HS.
DR GO; GO:0043159; C:acrosomal matrix; IDA:MGI.
DR GO; GO:0033150; C:cytoskeletal calyx; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; HDA:UniProtKB.
DR GO; GO:0005200; F:structural constituent of cytoskeleton; IEA:InterPro.
DR GO; GO:0005198; F:structural molecule activity; NAS:UniProtKB.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007283; P:spermatogenesis; NAS:UniProtKB.
DR InterPro; IPR026189; CYLC.
DR InterPro; IPR029354; Cylicin_N.
DR PANTHER; PTHR16742; PTHR16742; 1.
DR Pfam; PF15241; Cylicin_N; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Cytoskeleton; Developmental protein; Differentiation;
KW Reference proteome; Repeat; Spermatogenesis.
FT CHAIN 1..651
FT /note="Cylicin-1"
FT /id="PRO_0000079753"
FT REPEAT 278..305
FT /note="1"
FT REPEAT 306..342
FT /note="2"
FT REPEAT 343..379
FT /note="3"
FT REPEAT 380..417
FT /note="4"
FT REPEAT 418..453
FT /note="5"
FT REPEAT 454..491
FT /note="6"
FT REPEAT 492..531
FT /note="7"
FT REPEAT 532..553
FT /note="8"
FT REGION 110..241
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 267..615
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 532..553
FT /note="8 X approximate tandem repeats"
FT COMPBIAS 110..136
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 146..177
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 178..193
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 194..230
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 280..498
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 505..532
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 539..564
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 573..600
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 399
FT /note="D -> H (in dbSNP:rs12008888)"
FT /id="VAR_050937"
FT CONFLICT 54
FT /note="S -> G (in Ref. 3; CAA80457)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 651 AA; 74242 MW; EF63B156ADE67B85 CRC64;
MSLPRLLKVN IRTYDNSIPI SESSRKSWNQ KHFALTFPKP LQRGTNDKSR PLKSQITVTR
HDKRKLEEGQ KPAHKWIRHS FRKILQWPPI YTAAREQTPF RHLYTSKTHL KKAEYKKSKD
EKGGTPLKKD SKKKGGSYAT NPESKQIVEE KTKRQNEADK TPLKSSHENE QSKKSKSSSE
TNPESQNSKT VSKNCSQKDK KDSKNSKKTN TEFLHTKNNP KKDLKRSKTS NDPISEICSE
NSLNVDFLML VGQSDDESIN FDAWLRNYSQ NNSKNYSLKY TKYTKKDTKK NAKKSSDAES
EDSKDAKKDS KKVKKNVKKD DKKKDVKKDT ESTDAESGDS KDERKDTKKD KKKLKKDDKK
KDTKKYPEST DTESGDAKDA RNDSRNLKKA SKNDDKKKDA KKITFSTDSE SELESKESQK
DEKKDKKDSK TDNKKSVKND EESTDADSEP KGDSKKGKKD EKKGKKDSKK DDKKKDAKKN
AESTEMESDL ELKKDKKHSK EKKGSKKDIK KDARKDTEST DAEFDESSKT GFKTSTKIKG
SDTESEESLY KPGAKKKIDE SDGTSANSKM EGLESKRGFR MSSKKTTFNE KGEKASTGRV
PPSREKPPLP ACEPSLPSPK VRRLCWCKMP PPPPKPRYAP LPEAPWIHKL L
