ID   CYLC2_BOVIN             Reviewed;         488 AA.
AC   Q28092;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Cylicin-2;
DE   AltName: Full=Cylicin II;
DE   AltName: Full=Multiple-band polypeptide II;
GN   Name=CYLC2; Synonyms=CYL2;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Testis;
RX   PubMed=7737358; DOI=10.1006/excr.1995.1145;
RA   Hess H., Heid H., Zimbelmann R., Franke W.W.;
RT   "The protein complexity of the cytoskeleton of bovine and human sperm
RT   heads: the identification and characterization of cylicin II.";
RL   Exp. Cell Res. 218:174-182(1995).
RN   [2]
RP   PARTIAL PROTEIN SEQUENCE.
RX   PubMed=8354692; DOI=10.1083/jcb.122.5.1043;
RA   Hess H., Heid H., Franke W.W.;
RT   "Molecular characterization of mammalian cylicin, a basic protein of the
RT   sperm head cytoskeleton.";
RL   J. Cell Biol. 122:1043-1052(1993).
CC   -!- FUNCTION: Possible architectural role during spermatogenesis. May be
CC       involved in spermatid differentiation.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, perinuclear theca,
CC       calyx. Note=Sperm head cytoskeletal structure.
CC   -!- TISSUE SPECIFICITY: Testis.
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DR   EMBL; Z46789; CAA86753.1; -; mRNA.
DR   PIR; I46014; I46014.
DR   RefSeq; NP_776728.1; NM_174303.2.
DR   AlphaFoldDB; Q28092; -.
DR   STRING; 9913.ENSBTAP00000020732; -.
DR   PaxDb; Q28092; -.
DR   GeneID; 281738; -.
DR   KEGG; bta:281738; -.
DR   CTD; 1539; -.
DR   eggNOG; ENOG502SY9T; Eukaryota.
DR   InParanoid; Q28092; -.
DR   OrthoDB; 1524900at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0033150; C:cytoskeletal calyx; IEA:UniProtKB-SubCell.
DR   GO; GO:0005200; F:structural constituent of cytoskeleton; IEA:InterPro.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR   InterPro; IPR026189; CYLC.
DR   InterPro; IPR029354; Cylicin_N.
DR   PANTHER; PTHR16742; PTHR16742; 2.
DR   Pfam; PF15241; Cylicin_N; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Cytoskeleton; Developmental protein; Differentiation;
KW   Direct protein sequencing; Reference proteome; Repeat; Spermatogenesis.
FT   CHAIN           1..488
FT                   /note="Cylicin-2"
FT                   /id="PRO_0000079754"
FT   REPEAT          189..212
FT                   /note="1"
FT   REPEAT          213..239
FT                   /note="2"
FT   REPEAT          240..267
FT                   /note="3"
FT   REPEAT          268..295
FT                   /note="4"
FT   REPEAT          296..323
FT                   /note="5"
FT   REPEAT          324..351
FT                   /note="6"
FT   REPEAT          352..379
FT                   /note="7"
FT   REPEAT          380..407
FT                   /note="8"
FT   REGION          25..487
FT                   /note="49 X 3 AA repeats of K-K-X"
FT   REGION          34..488
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          189..407
FT                   /note="8 X approximate tandem repeats"
FT   COMPBIAS        61..77
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        115..482
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   488 AA;  53562 MW;  5F3107CE2D019C5A CRC64;
     MSVPRFQKIN FGAYDNYVPV SELSKKSWNQ QHFALVFPKP PRPGKRRRSK PSLLQENTSP
     KYDAEKLRGD RKQPLWMHRS LMRISERPSV YLAARSRHPQ KETPPSQEDA KQAAKPSSPK
     VKKSKEDKDK SDSEAESIVS KEKPRKLSKA KEEKPDEKKD LKKERKDSKK GKESATESED
     EKAGAEKGAK KDRKGSKKGK ETPSDSGSEK GDAKKDSKKS KKDSKGKESA TESEGEKGDA
     KKDDKKGKKG SKKGKESATE SEGEKGDAKK DDKKGKKGSK KGKESATESE GEKGDAKKDD
     KKGKKGSKKG KESATESEGE KGDAKKDDKK GKKGSKKGKE SATESEGEKG DAKKDDKKGK
     KGSKKGKESD SKAEGDKGDA KKDDKKDKKG SKKGKESATE SEGEKKDSKK DKAGKKDPTK
     AGEKGDESKD KKDAKKKDSK KEKKDEKKPG EAESEPKDSA KKDAKKDAKK DAKKDAKKDA
     KKDAKKGK