CYLC2_HUMAN
ID CYLC2_HUMAN Reviewed; 348 AA.
AC Q14093; B2R8F4; Q5VVJ9;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 1.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Cylicin-2;
DE AltName: Full=Cylicin II;
DE AltName: Full=Multiple-band polypeptide II;
GN Name=CYLC2; Synonyms=CYL2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Testis;
RX PubMed=7737358; DOI=10.1006/excr.1995.1145;
RA Hess H., Heid H., Zimbelmann R., Franke W.W.;
RT "The protein complexity of the cytoskeleton of bovine and human sperm
RT heads: the identification and characterization of cylicin II.";
RL Exp. Cell Res. 218:174-182(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Possible architectural role during spermatogenesis. May be
CC involved in spermatid differentiation.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, perinuclear theca,
CC calyx. Note=Sperm head cytoskeletal structure.
CC -!- TISSUE SPECIFICITY: Testis.
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DR EMBL; Z46788; CAA86752.1; -; mRNA.
DR EMBL; AK313349; BAG36151.1; -; mRNA.
DR EMBL; AL449304; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC114547; AAI14548.1; -; mRNA.
DR CCDS; CCDS35085.1; -.
DR PIR; I37271; I37271.
DR RefSeq; NP_001331.1; NM_001340.4.
DR AlphaFoldDB; Q14093; -.
DR BioGRID; 107919; 18.
DR IntAct; Q14093; 15.
DR MINT; Q14093; -.
DR STRING; 9606.ENSP00000420256; -.
DR iPTMnet; Q14093; -.
DR PhosphoSitePlus; Q14093; -.
DR BioMuta; CYLC2; -.
DR DMDM; 2498278; -.
DR MassIVE; Q14093; -.
DR PaxDb; Q14093; -.
DR PeptideAtlas; Q14093; -.
DR PRIDE; Q14093; -.
DR ProteomicsDB; 59808; -.
DR Antibodypedia; 29199; 86 antibodies from 23 providers.
DR DNASU; 1539; -.
DR Ensembl; ENST00000374798.8; ENSP00000420256.1; ENSG00000155833.15.
DR Ensembl; ENST00000487798.5; ENSP00000417674.1; ENSG00000155833.15.
DR Ensembl; ENST00000612124.4; ENSP00000478399.1; ENSG00000155833.15.
DR GeneID; 1539; -.
DR KEGG; hsa:1539; -.
DR MANE-Select; ENST00000374798.8; ENSP00000420256.1; NM_001340.5; NP_001331.1.
DR UCSC; uc004bbs.2; human.
DR CTD; 1539; -.
DR DisGeNET; 1539; -.
DR GeneCards; CYLC2; -.
DR HGNC; HGNC:2583; CYLC2.
DR HPA; ENSG00000155833; Tissue enriched (testis).
DR MIM; 604035; gene.
DR neXtProt; NX_Q14093; -.
DR OpenTargets; ENSG00000155833; -.
DR PharmGKB; PA27083; -.
DR VEuPathDB; HostDB:ENSG00000155833; -.
DR eggNOG; ENOG502SY9T; Eukaryota.
DR GeneTree; ENSGT00730000111075; -.
DR HOGENOM; CLU_055233_0_0_1; -.
DR InParanoid; Q14093; -.
DR OMA; RDNTVPI; -.
DR OrthoDB; 1524900at2759; -.
DR PhylomeDB; Q14093; -.
DR TreeFam; TF337809; -.
DR PathwayCommons; Q14093; -.
DR SignaLink; Q14093; -.
DR BioGRID-ORCS; 1539; 11 hits in 1067 CRISPR screens.
DR ChiTaRS; CYLC2; human.
DR GenomeRNAi; 1539; -.
DR Pharos; Q14093; Tbio.
DR PRO; PR:Q14093; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; Q14093; protein.
DR Bgee; ENSG00000155833; Expressed in sperm and 100 other tissues.
DR ExpressionAtlas; Q14093; baseline and differential.
DR Genevisible; Q14093; HS.
DR GO; GO:0033150; C:cytoskeletal calyx; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; HDA:UniProtKB.
DR GO; GO:0005200; F:structural constituent of cytoskeleton; TAS:ProtInc.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR InterPro; IPR026189; CYLC.
DR InterPro; IPR029354; Cylicin_N.
DR PANTHER; PTHR16742; PTHR16742; 2.
DR Pfam; PF15241; Cylicin_N; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Cytoskeleton; Developmental protein; Differentiation;
KW Reference proteome; Repeat; Spermatogenesis.
FT CHAIN 1..348
FT /note="Cylicin-2"
FT /id="PRO_0000079755"
FT REPEAT 157..184
FT /note="1"
FT REPEAT 185..212
FT /note="2"
FT REPEAT 213..240
FT /note="3"
FT REGION 25..347
FT /note="31 X 3 AA repeats of K-K-X"
FT REGION 35..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 101..348
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 157..240
FT /note="3 X approximate tandem repeats"
FT COMPBIAS 101..267
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 273..342
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 146
FT /note="D -> Y (in dbSNP:rs13293961)"
FT /id="VAR_050938"
FT VARIANT 184
FT /note="G -> D (in dbSNP:rs10990424)"
FT /id="VAR_050939"
FT VARIANT 190
FT /note="K -> E (in dbSNP:rs2298050)"
FT /id="VAR_020100"
FT VARIANT 208
FT /note="G -> D (in dbSNP:rs2298051)"
FT /id="VAR_020101"
FT VARIANT 319
FT /note="A -> E (in dbSNP:rs3763636)"
FT /id="VAR_020102"
SQ SEQUENCE 348 AA; 39079 MW; D86766599C1809E7 CRC64;
MSLPRFQRVN FGPYDNYIPV SELSKKSWNQ QHFALLFPKP QRPGTKRRSK PSQIRDNTVS
IIDEEQLRGD RRQPLWMYRS LMRISERPSV YLAARRQPLK PTRTVEVDSK AAEIGKKGED
KTTQKDTTDS ESELKQGKKD SKKGKDIEKG KEEKLDAKKD SKKGKKDAEK GKDSATESED
EKGGAKKDNK KDKKDSNKGK DSATESEGEK GGTEKDSKKG KKDSKKGKDS AIELQAVKAD
EKKDEDGKKD ANKGDESKDA KKDAKEIKKG KKDKKKPSST DSDSKDDVKK ESKKDATKDA
KKVAKKDTEK ESADSKKDAK KNAKKDAKKD AKKNAKKDEK KDAKKKGK
