ID   CYMR_PSEPU              Reviewed;         203 AA.
AC   O33453;
DT   22-NOV-2017, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 97.
DE   RecName: Full=HTH-type transcriptional regulator CymR {ECO:0000303|PubMed:9150211};
GN   Name=cymR {ECO:0000303|PubMed:9150211};
OS   Pseudomonas putida (Arthrobacter siderocapsulatus).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=303;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=F1 {ECO:0000312|EMBL:AAB62296.1};
RX   PubMed=8631713; DOI=10.1128/jb.178.5.1351-1362.1996;
RA   Eaton R.W.;
RT   "p-cumate catabolic pathway in Pseudomonas putida F1: cloning and
RT   characterization of DNA carrying the cmt operon.";
RL   J. Bacteriol. 178:1351-1362(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND INDUCTION.
RC   STRAIN=F1 {ECO:0000312|EMBL:AAB62296.1};
RX   PubMed=9150211; DOI=10.1128/jb.179.10.3171-3180.1997;
RA   Eaton R.W.;
RT   "p-Cymene catabolic pathway in Pseudomonas putida F1: cloning and
RT   characterization of DNA encoding conversion of p-cymene to p-cumate.";
RL   J. Bacteriol. 179:3171-3180(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11160798; DOI=10.1099/00221287-147-1-31;
RA   Ohta Y., Maeda M., Kudo T.;
RT   "Pseudomonas putida CE2010 can degrade biphenyl by a mosaic pathway encoded
RT   by the tod operon and cmtE, which are identical to those of P. putida F1
RT   except for a single base difference in the operator-promoter region of the
RT   cmt operon.";
RL   Microbiology 147:31-41(2001).
CC   -!- FUNCTION: Involved in the repression of the cym and cmt operons which
CC       are responsible of the p-cymene degradation.
CC       {ECO:0000269|PubMed:9150211}.
CC   -!- INDUCTION: Induced by p-cumate. {ECO:0000269|PubMed:9150211}.
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DR   EMBL; U24215; AAB62296.1; -; Genomic_DNA.
DR   EMBL; AB042509; BAB17786.1; -; Genomic_DNA.
DR   AlphaFoldDB; O33453; -.
DR   SMR; O33453; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001647; HTH_TetR.
DR   InterPro; IPR036271; Tet_transcr_reg_TetR-rel_C_sf.
DR   Pfam; PF00440; TetR_N; 1.
DR   PRINTS; PR00455; HTHTETR.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   SUPFAM; SSF48498; SSF48498; 1.
DR   PROSITE; PS50977; HTH_TETR_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..203
FT                   /note="HTH-type transcriptional regulator CymR"
FT                   /id="PRO_0000442285"
FT   DOMAIN          13..73
FT                   /note="HTH tetR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
FT   DNA_BIND        36..55
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
SQ   SEQUENCE   203 AA;  23323 MW;  43A1BF69B9A2CD8F CRC64;
     MSPKRRTQAE RAMETQGKLI AAALGVLREK GYAGFRIADV PGAAGVSRGA QSHHFPTKLE
     LLLATFEWLY EQITERSRAR LAKLKPEDDV IQQMLDDAAE FFLDDDFSIS LDLIVAADRD
     PALREGIQRT VERNRFVVED MWLGVLVSRG LSRDDAEDIL WLIFNSVRGL AVRSLWQKDK
     ERFERVRNST LEIARERYAK FKR