CYNS_MYCPA
ID CYNS_MYCPA Reviewed; 155 AA.
AC P61192;
DT 10-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT 10-MAY-2004, sequence version 1.
DT 25-MAY-2022, entry version 97.
DE RecName: Full=Cyanate hydratase {ECO:0000255|HAMAP-Rule:MF_00535};
DE Short=Cyanase {ECO:0000255|HAMAP-Rule:MF_00535};
DE EC=4.2.1.104 {ECO:0000255|HAMAP-Rule:MF_00535};
DE AltName: Full=Cyanate hydrolase {ECO:0000255|HAMAP-Rule:MF_00535};
DE AltName: Full=Cyanate lyase {ECO:0000255|HAMAP-Rule:MF_00535};
GN Name=cynS {ECO:0000255|HAMAP-Rule:MF_00535}; OrderedLocusNames=MAP_4098;
OS Mycolicibacterium paratuberculosis (strain ATCC BAA-968 / K-10)
OS (Mycobacterium paratuberculosis).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium avium complex (MAC).
OX NCBI_TaxID=262316;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-968 / K-10;
RX PubMed=16116077; DOI=10.1073/pnas.0505662102;
RA Li L., Bannantine J.P., Zhang Q., Amonsin A., May B.J., Alt D., Banerji N.,
RA Kanjilal S., Kapur V.;
RT "The complete genome sequence of Mycobacterium avium subspecies
RT paratuberculosis.";
RL Proc. Natl. Acad. Sci. U.S.A. 102:12344-12349(2005).
CC -!- FUNCTION: Catalyzes the reaction of cyanate with bicarbonate to produce
CC ammonia and carbon dioxide. {ECO:0000255|HAMAP-Rule:MF_00535}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=cyanate + 3 H(+) + hydrogencarbonate = 2 CO2 + NH4(+);
CC Xref=Rhea:RHEA:11120, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526,
CC ChEBI:CHEBI:17544, ChEBI:CHEBI:28938, ChEBI:CHEBI:29195;
CC EC=4.2.1.104; Evidence={ECO:0000255|HAMAP-Rule:MF_00535};
CC -!- SIMILARITY: Belongs to the cyanase family. {ECO:0000255|HAMAP-
CC Rule:MF_00535}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAS06648.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AE016958; AAS06648.1; ALT_INIT; Genomic_DNA.
DR RefSeq; WP_003873583.1; NC_002944.2.
DR AlphaFoldDB; P61192; -.
DR SMR; P61192; -.
DR STRING; 262316.MAP_4098; -.
DR EnsemblBacteria; AAS06648; AAS06648; MAP_4098.
DR KEGG; mpa:MAP_4098; -.
DR eggNOG; COG1513; Bacteria.
DR HOGENOM; CLU_103452_1_0_11; -.
DR OMA; YELVMIN; -.
DR Proteomes; UP000000580; Chromosome.
DR GO; GO:0008824; F:cyanate hydratase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0009439; P:cyanate metabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd00559; Cyanase_C; 1.
DR Gene3D; 1.10.260.40; -; 1.
DR Gene3D; 3.30.1160.10; -; 1.
DR HAMAP; MF_00535; Cyanate_hydrat; 1.
DR InterPro; IPR008076; Cyanase.
DR InterPro; IPR003712; Cyanate_lyase_C.
DR InterPro; IPR036581; Cyanate_lyase_C_sf.
DR InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR PANTHER; PTHR34186; PTHR34186; 1.
DR Pfam; PF02560; Cyanate_lyase; 1.
DR PIRSF; PIRSF001263; Cyanate_hydratas; 1.
DR PRINTS; PR01693; CYANASE.
DR SMART; SM01116; Cyanate_lyase; 1.
DR SUPFAM; SSF47413; SSF47413; 1.
DR SUPFAM; SSF55234; SSF55234; 1.
DR TIGRFAMs; TIGR00673; cynS; 1.
PE 3: Inferred from homology;
KW Lyase; Reference proteome.
FT CHAIN 1..155
FT /note="Cyanate hydratase"
FT /id="PRO_0000187525"
FT ACT_SITE 92
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00535"
FT ACT_SITE 95
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00535"
FT ACT_SITE 118
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00535"
SQ SEQUENCE 155 AA; 16941 MW; AE1383398F0B92C9 CRC64;
MLGRMTRNQL TEQIVVARLA KGLTWQELAD AIGRPLLWTT SALLGQHPIP AELGRILVDK
LGLDESAVPV LAAPPMRGGL PTAVPTDPTI YRFYEALQVY GGALKEVIAE QFGDGIMSAI
NFSVDLQKKP HPSGDRVVVT FDGKFLPYQW VSSEQ
