CYNX_ECOLI
ID CYNX_ECOLI Reviewed; 384 AA.
AC P17583; P71308; P75695; Q2MC83;
DT 01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 2.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=Cyanate transport protein CynX;
GN Name=cynX; OrderedLocusNames=b0341, JW0332;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=K12;
RX PubMed=3049588; DOI=10.1016/s0021-9258(18)68104-9;
RA Sung Y.-C., Fuchs J.A.;
RT "Characterization of the cyn operon in Escherichia coli K12.";
RL J. Biol. Chem. 263:14769-14775(1988).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RA Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M.,
RA Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D.,
RA Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.;
RT "Sequence of minutes 4-25 of Escherichia coli.";
RL Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [5]
RP SUBCELLULAR LOCATION.
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=15919996; DOI=10.1126/science.1109730;
RA Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.;
RT "Global topology analysis of the Escherichia coli inner membrane
RT proteome.";
RL Science 308:1321-1323(2005).
CC -!- FUNCTION: This protein is part of an active transport system that
CC transports exogenous cyanate into E.coli cells.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:15919996}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Cyanate
CC porter (TC 2.A.1.17) family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB18065.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; M23219; AAA23627.1; -; Genomic_DNA.
DR EMBL; U73857; AAB18065.1; ALT_INIT; Genomic_DNA.
DR EMBL; U00096; AAC73444.1; -; Genomic_DNA.
DR EMBL; AP009048; BAE76123.1; -; Genomic_DNA.
DR PIR; E64761; BVECCX.
DR RefSeq; NP_414875.1; NC_000913.3.
DR AlphaFoldDB; P17583; -.
DR SMR; P17583; -.
DR BioGRID; 4263183; 8.
DR STRING; 511145.b0341; -.
DR TCDB; 2.A.1.17.1; the major facilitator superfamily (mfs).
DR PaxDb; P17583; -.
DR PRIDE; P17583; -.
DR EnsemblBacteria; AAC73444; AAC73444; b0341.
DR EnsemblBacteria; BAE76123; BAE76123; BAE76123.
DR GeneID; 946770; -.
DR KEGG; ecj:JW0332; -.
DR KEGG; eco:b0341; -.
DR PATRIC; fig|511145.12.peg.349; -.
DR EchoBASE; EB0174; -.
DR eggNOG; COG2807; Bacteria.
DR HOGENOM; CLU_038046_4_0_6; -.
DR InParanoid; P17583; -.
DR OMA; GGYTSMV; -.
DR PhylomeDB; P17583; -.
DR BioCyc; EcoCyc:CYNX-MON; -.
DR PRO; PR:P17583; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IDA:EcoCyc.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0009440; P:cyanate catabolic process; IEP:EcoCyc.
DR Gene3D; 1.20.1250.20; -; 2.
DR InterPro; IPR004747; Cyan_transport.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR TIGRFAMs; TIGR00896; CynX; 1.
DR PROSITE; PS50850; MFS; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..384
FT /note="Cyanate transport protein CynX"
FT /id="PRO_0000205707"
FT TRANSMEM 3..23
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 34..54
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 68..88
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 89..109
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 122..142
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 153..173
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 204..224
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 235..255
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 263..283
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 287..307
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 322..342
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 354..374
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 27
FT /note="R -> A (in Ref. 1; AAA23627)"
FT /evidence="ECO:0000305"
FT CONFLICT 336..384
FT /note="APWFSGVLRSISGNYLMDWAFHALCVVGLMIITLRFAPVRFPQLWVKEA ->
FT PRGFLACCVVSAAIT (in Ref. 1)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 384 AA; 41361 MW; 05A579C7988E90A7 CRC64;
MLLVLVLIGL NMRPLLTSVG PLLPQLRQAS GMSFSVAALL TALPVVTMGG LALAGSWLHQ
HVSERRSVAI SLLLIAVGAL MRELYPQSAL LLSSALLGGV GIGIIQAVMP SVIKRRFQQR
TPLVMGLWSA ALMGGGGLGA AITPWLVQHS ETWYQTLAWW ALPAVVALFA WWWQSAREVA
SSHKTTTTPV RVVFTPRAWT LGVYFGLING GYASLIAWLP AFYIEIGASA QYSGSLLALM
TLGQAAGALL MPAMARHQDR RKLLMLALVL QLVGFCGFIW LPMQLPVLWA MVCGLGLGGA
FPLCLLLALD HSVQPAIAGK LVAFMQGIGF IIAGLAPWFS GVLRSISGNY LMDWAFHALC
VVGLMIITLR FAPVRFPQLW VKEA
