ID   CYOC_BUCAI              Reviewed;         205 AA.
AC   P57542;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2000, sequence version 1.
DT   25-MAY-2022, entry version 112.
DE   RecName: Full=Cytochrome bo(3) ubiquinol oxidase subunit 3;
DE   AltName: Full=Cytochrome o ubiquinol oxidase subunit 3;
DE            Short=Cytochrome o subunit 3;
DE   AltName: Full=Oxidase bo(3) subunit 3;
DE   AltName: Full=Ubiquinol oxidase polypeptide III;
DE   AltName: Full=Ubiquinol oxidase subunit 3;
GN   Name=cyoC; OrderedLocusNames=BU470;
OS   Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon
OS   pisum symbiotic bacterium).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Erwiniaceae; Buchnera.
OX   NCBI_TaxID=107806;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=APS;
RX   PubMed=10993077; DOI=10.1038/35024074;
RA   Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.;
RT   "Genome sequence of the endocellular bacterial symbiont of aphids Buchnera
RT   sp. APS.";
RL   Nature 407:81-86(2000).
CC   -!- FUNCTION: Cytochrome bo(3) ubiquinol terminal oxidase is the component
CC       of the aerobic respiratory chain of E.coli that predominates when cells
CC       are grown at high aeration. Has proton pump activity across the
CC       membrane in addition to electron transfer, pumping 2 protons/electron
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Heterooctamer of two A chains, two B chains, two C chains and
CC       two D chains. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the cytochrome c oxidase subunit 3 family.
CC       {ECO:0000305}.
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DR   EMBL; BA000003; BAB13167.1; -; Genomic_DNA.
DR   RefSeq; NP_240281.1; NC_002528.1.
DR   RefSeq; WP_009874422.1; NC_002528.1.
DR   AlphaFoldDB; P57542; -.
DR   SMR; P57542; -.
DR   STRING; 107806.10039133; -.
DR   EnsemblBacteria; BAB13167; BAB13167; BAB13167.
DR   KEGG; buc:BU470; -.
DR   PATRIC; fig|107806.10.peg.479; -.
DR   eggNOG; COG1845; Bacteria.
DR   HOGENOM; CLU_044071_3_0_6; -.
DR   OMA; SIYWWGS; -.
DR   Proteomes; UP000001806; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0009486; F:cytochrome bo3 ubiquinol oxidase activity; IEA:InterPro.
DR   GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:InterPro.
DR   GO; GO:0019646; P:aerobic electron transport chain; IEA:InterPro.
DR   Gene3D; 1.20.120.80; -; 1.
DR   InterPro; IPR024791; Cyt_c/ubiquinol_Oxase_su3.
DR   InterPro; IPR000298; Cyt_c_oxidase-like_su3.
DR   InterPro; IPR035973; Cyt_c_oxidase_su3-like_sf.
DR   InterPro; IPR013833; Cyt_c_oxidase_su3_a-hlx.
DR   InterPro; IPR014206; Cyt_c_ubiqinol_oxidase_su3.
DR   PANTHER; PTHR11403; PTHR11403; 1.
DR   Pfam; PF00510; COX3; 1.
DR   SUPFAM; SSF81452; SSF81452; 1.
DR   TIGRFAMs; TIGR02842; CyoC; 1.
DR   PROSITE; PS50253; COX3; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Electron transport; Membrane; Oxidoreductase;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..205
FT                   /note="Cytochrome bo(3) ubiquinol oxidase subunit 3"
FT                   /id="PRO_0000183896"
FT   TOPO_DOM        1..26
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        27..47
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        48..69
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        70..90
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        91..97
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        98..118
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        119..138
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        139..159
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        160..177
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        178..198
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        199..205
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   205 AA;  23639 MW;  E4B2A7EC05E184DB CRC64;
     MIENKFNNTI LNSNSSTHDK ISETKKLFGL WIYLMSDCIM FAVLFAVYAI VSSNISINLI
     SNKIFNLSSI LLETFLLLLS SLSCGFVVIA MNQKRIKMIY SFLTITFIFG LIFLLMEVHE
     FYELIIENFG PDKNAFFSIF FTLVATHGVH IFFGLILILS ILYQIKKLGL TNSIRTRILC
     FSVFWHFLDI IWICVFTFVY LNGAI