ID   CYOC_BUCAP              Reviewed;         189 AA.
AC   Q8K995;
DT   08-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=Cytochrome bo(3) ubiquinol oxidase subunit 3;
DE   AltName: Full=Cytochrome o ubiquinol oxidase subunit 3;
DE            Short=Cytochrome o subunit 3;
DE   AltName: Full=Oxidase bo(3) subunit 3;
DE   AltName: Full=Ubiquinol oxidase polypeptide III;
DE   AltName: Full=Ubiquinol oxidase subunit 3;
GN   Name=cyoC; OrderedLocusNames=BUsg_454;
OS   Buchnera aphidicola subsp. Schizaphis graminum (strain Sg).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Erwiniaceae; Buchnera.
OX   NCBI_TaxID=198804;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Sg;
RX   PubMed=12089438; DOI=10.1126/science.1071278;
RA   Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S.,
RA   Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E.;
RT   "50 million years of genomic stasis in endosymbiotic bacteria.";
RL   Science 296:2376-2379(2002).
CC   -!- FUNCTION: Cytochrome bo(3) ubiquinol terminal oxidase is the component
CC       of the aerobic respiratory chain of E.coli that predominates when cells
CC       are grown at high aeration. Has proton pump activity across the
CC       membrane in addition to electron transfer, pumping 2 protons/electron
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Heterooctamer of two A chains, two B chains, two C chains and
CC       two D chains. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the cytochrome c oxidase subunit 3 family.
CC       {ECO:0000305}.
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DR   EMBL; AE013218; AAM67997.1; -; Genomic_DNA.
DR   RefSeq; WP_011053964.1; NC_004061.1.
DR   AlphaFoldDB; Q8K995; -.
DR   SMR; Q8K995; -.
DR   STRING; 198804.BUsg_454; -.
DR   EnsemblBacteria; AAM67997; AAM67997; BUsg_454.
DR   KEGG; bas:BUsg_454; -.
DR   eggNOG; COG1845; Bacteria.
DR   HOGENOM; CLU_044071_3_0_6; -.
DR   OMA; SIYWWGS; -.
DR   OrthoDB; 1502742at2; -.
DR   Proteomes; UP000000416; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0009486; F:cytochrome bo3 ubiquinol oxidase activity; IEA:InterPro.
DR   GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:InterPro.
DR   GO; GO:0019646; P:aerobic electron transport chain; IEA:InterPro.
DR   Gene3D; 1.20.120.80; -; 1.
DR   InterPro; IPR024791; Cyt_c/ubiquinol_Oxase_su3.
DR   InterPro; IPR000298; Cyt_c_oxidase-like_su3.
DR   InterPro; IPR035973; Cyt_c_oxidase_su3-like_sf.
DR   InterPro; IPR013833; Cyt_c_oxidase_su3_a-hlx.
DR   InterPro; IPR014206; Cyt_c_ubiqinol_oxidase_su3.
DR   PANTHER; PTHR11403; PTHR11403; 1.
DR   Pfam; PF00510; COX3; 1.
DR   SUPFAM; SSF81452; SSF81452; 1.
DR   TIGRFAMs; TIGR02842; CyoC; 1.
DR   PROSITE; PS50253; COX3; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Electron transport; Membrane; Oxidoreductase; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..189
FT                   /note="Cytochrome bo(3) ubiquinol oxidase subunit 3"
FT                   /id="PRO_0000183897"
FT   TOPO_DOM        1..10
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        11..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        32..52
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        53..73
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        74..81
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        82..102
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        103..122
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        123..143
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        144..161
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        162..182
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        183..189
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   189 AA;  22163 MW;  1513BB6C59C9F558 CRC64;
     MIKETMRNNK LFGLWIYLMS DCIIFAVLFA VYAIISSNFS TNLINHKIFN LSYVFLETLI
     LLLSSLSSGM LTIQKNKNNI KIIYFYLLLT FFLGLSFLLM EVNEFYKLIL ENCSPSQHAF
     FSIFFTIVGV HGIHVFFGLI FILSILYQLF YLGITNTIRI RILCFSLFWH FLDIIWICVF
     TFVYLNGVI