ID   CYOC_BUCBP              Reviewed;         194 AA.
AC   Q89AA5;
DT   13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   25-MAY-2022, entry version 103.
DE   RecName: Full=Cytochrome bo(3) ubiquinol oxidase subunit 3;
DE   AltName: Full=Cytochrome o ubiquinol oxidase subunit 3;
DE            Short=Cytochrome o subunit 3;
DE   AltName: Full=Oxidase bo(3) subunit 3;
DE   AltName: Full=Ubiquinol oxidase polypeptide III;
DE   AltName: Full=Ubiquinol oxidase subunit 3;
GN   Name=cyoC; OrderedLocusNames=bbp_415;
OS   Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Erwiniaceae; Buchnera.
OX   NCBI_TaxID=224915;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bp;
RX   PubMed=12522265; DOI=10.1073/pnas.0235981100;
RA   van Ham R.C.H.J., Kamerbeek J., Palacios C., Rausell C., Abascal F.,
RA   Bastolla U., Fernandez J.M., Jimenez L., Postigo M., Silva F.J.,
RA   Tamames J., Viguera E., Latorre A., Valencia A., Moran F., Moya A.;
RT   "Reductive genome evolution in Buchnera aphidicola.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:581-586(2003).
CC   -!- FUNCTION: Cytochrome bo(3) ubiquinol terminal oxidase is the component
CC       of the aerobic respiratory chain of E.coli that predominates when cells
CC       are grown at high aeration. Has proton pump activity across the
CC       membrane in addition to electron transfer, pumping 2 protons/electron
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Heterooctamer of two A chains, two B chains, two C chains and
CC       two D chains. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the cytochrome c oxidase subunit 3 family.
CC       {ECO:0000305}.
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DR   EMBL; AE016826; AAO27125.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q89AA5; -.
DR   SMR; Q89AA5; -.
DR   STRING; 224915.bbp_415; -.
DR   EnsemblBacteria; AAO27125; AAO27125; bbp_415.
DR   KEGG; bab:bbp_415; -.
DR   eggNOG; COG1845; Bacteria.
DR   HOGENOM; CLU_044071_3_0_6; -.
DR   OMA; SIYWWGS; -.
DR   Proteomes; UP000000601; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0009486; F:cytochrome bo3 ubiquinol oxidase activity; IEA:InterPro.
DR   GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:InterPro.
DR   GO; GO:0019646; P:aerobic electron transport chain; IEA:InterPro.
DR   CDD; cd02863; Ubiquinol_oxidase_III; 1.
DR   Gene3D; 1.20.120.80; -; 1.
DR   InterPro; IPR024791; Cyt_c/ubiquinol_Oxase_su3.
DR   InterPro; IPR000298; Cyt_c_oxidase-like_su3.
DR   InterPro; IPR035973; Cyt_c_oxidase_su3-like_sf.
DR   InterPro; IPR013833; Cyt_c_oxidase_su3_a-hlx.
DR   InterPro; IPR014206; Cyt_c_ubiqinol_oxidase_su3.
DR   InterPro; IPR033946; Ubiquinol_oxase_su3_dom.
DR   PANTHER; PTHR11403; PTHR11403; 1.
DR   Pfam; PF00510; COX3; 1.
DR   SUPFAM; SSF81452; SSF81452; 1.
DR   TIGRFAMs; TIGR02842; CyoC; 1.
DR   PROSITE; PS50253; COX3; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Electron transport; Membrane; Oxidoreductase;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..194
FT                   /note="Cytochrome bo(3) ubiquinol oxidase subunit 3"
FT                   /id="PRO_0000183898"
FT   TOPO_DOM        1..18
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        19..41
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        42..55
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        56..78
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        79..84
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        85..107
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        108..126
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        127..149
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        150..169
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        170..192
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        193..194
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   194 AA;  22941 MW;  5100E603AA6CBB02 CRC64;
     MKKKYKIDTN IFSKELLGFW LYLMSDCIIF CTLFSVYFIL VDNVAQGPSG HNIFQNNLII
     IETFLLLFSS FSCNLVLFEM KNKNLYMVFL WLGITFLLGL LFVFLELFEF FHLINLGFGP
     TRSGFLSSFF VLIATHGIHV ISGLIWIIVM IKYVYTFNIT NLIYYRMLCL NLFWHFLDIV
     WVFIFSFVYL FGMV