ID   CYOC_ECOL6              Reviewed;         204 AA.
AC   P0ABJ4; P18402;
DT   25-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Cytochrome bo(3) ubiquinol oxidase subunit 3;
DE   AltName: Full=Cytochrome o ubiquinol oxidase subunit 3;
DE            Short=Cytochrome o subunit 3;
DE   AltName: Full=Oxidase bo(3) subunit 3;
DE   AltName: Full=Ubiquinol oxidase chain C;
DE   AltName: Full=Ubiquinol oxidase polypeptide III;
DE   AltName: Full=Ubiquinol oxidase subunit 3;
GN   Name=cyoC; OrderedLocusNames=c0541;
OS   Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=199310;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CFT073 / ATCC 700928 / UPEC;
RX   PubMed=12471157; DOI=10.1073/pnas.252529799;
RA   Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D.,
RA   Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F.,
RA   Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T.,
RA   Donnenberg M.S., Blattner F.R.;
RT   "Extensive mosaic structure revealed by the complete genome sequence of
RT   uropathogenic Escherichia coli.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002).
CC   -!- FUNCTION: Cytochrome bo(3) ubiquinol terminal oxidase is the component
CC       of the aerobic respiratory chain of E.coli that predominates when cells
CC       are grown at high aeration. Has proton pump activity across the
CC       membrane in addition to electron transfer, pumping 2 protons/electron
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Heterooctamer of two A chains, two B chains, two C chains and
CC       two D chains. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the cytochrome c oxidase subunit 3 family.
CC       {ECO:0000305}.
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DR   EMBL; AE014075; AAN79019.1; -; Genomic_DNA.
DR   RefSeq; WP_000179819.1; NC_004431.1.
DR   AlphaFoldDB; P0ABJ4; -.
DR   SMR; P0ABJ4; -.
DR   STRING; 199310.c0541; -.
DR   EnsemblBacteria; AAN79019; AAN79019; c0541.
DR   GeneID; 66671268; -.
DR   KEGG; ecc:c0541; -.
DR   eggNOG; COG1845; Bacteria.
DR   HOGENOM; CLU_044071_3_0_6; -.
DR   OMA; SIYWWGS; -.
DR   BioCyc; ECOL199310:C0541-MON; -.
DR   Proteomes; UP000001410; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0009486; F:cytochrome bo3 ubiquinol oxidase activity; IEA:InterPro.
DR   GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:InterPro.
DR   GO; GO:0019646; P:aerobic electron transport chain; IEA:InterPro.
DR   CDD; cd02863; Ubiquinol_oxidase_III; 1.
DR   Gene3D; 1.20.120.80; -; 1.
DR   InterPro; IPR024791; Cyt_c/ubiquinol_Oxase_su3.
DR   InterPro; IPR000298; Cyt_c_oxidase-like_su3.
DR   InterPro; IPR035973; Cyt_c_oxidase_su3-like_sf.
DR   InterPro; IPR013833; Cyt_c_oxidase_su3_a-hlx.
DR   InterPro; IPR014206; Cyt_c_ubiqinol_oxidase_su3.
DR   InterPro; IPR033946; Ubiquinol_oxase_su3_dom.
DR   PANTHER; PTHR11403; PTHR11403; 1.
DR   Pfam; PF00510; COX3; 1.
DR   SUPFAM; SSF81452; SSF81452; 1.
DR   TIGRFAMs; TIGR02842; CyoC; 1.
DR   PROSITE; PS50253; COX3; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Electron transport; Membrane;
KW   Oxidoreductase; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..204
FT                   /note="Cytochrome bo(3) ubiquinol oxidase subunit 3"
FT                   /id="PRO_0000183894"
FT   TOPO_DOM        1..31
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        32..50
FT                   /note="Helical"
FT                   /evidence="ECO:0000305"
FT   TOPO_DOM        51..66
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        67..85
FT                   /note="Helical"
FT                   /evidence="ECO:0000305"
FT   TOPO_DOM        86..101
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        102..120
FT                   /note="Helical"
FT                   /evidence="ECO:0000305"
FT   TOPO_DOM        121..142
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        143..161
FT                   /note="Helical"
FT                   /evidence="ECO:0000305"
FT   TOPO_DOM        162..184
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        185..203
FT                   /note="Helical"
FT                   /evidence="ECO:0000305"
FT   TOPO_DOM        204
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   204 AA;  22623 MW;  F1D6ABF9EB6CB5AD CRC64;
     MATDTLTHAT AHAHEHGHHD AGGTKIFGFW IYLMSDCILF SILFATYAVL VNGTAGGPTG
     KDIFELPFVL VETFLLLFSS ITYGMAAIAM YKNNKSQVIS WLALTWLFGA GFIGMEIYEF
     HHLIVNGMGP DRSGFLSAFF ALVGTHGLHV TSGLIWMAVL MVQIARRGLT STNRTRIMCL
     SLFWHFLDVV WICVFTVVYL MGAM