CYOC_SHIFL
ID CYOC_SHIFL Reviewed; 204 AA.
AC P0ABJ5; P18402;
DT 25-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT 25-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Cytochrome bo(3) ubiquinol oxidase subunit 3;
DE AltName: Full=Cytochrome o ubiquinol oxidase subunit 3;
DE Short=Cytochrome o subunit 3;
DE AltName: Full=Oxidase bo(3) subunit 3;
DE AltName: Full=Ubiquinol oxidase chain C;
DE AltName: Full=Ubiquinol oxidase polypeptide III;
DE AltName: Full=Ubiquinol oxidase subunit 3;
GN Name=cyoC; OrderedLocusNames=SF0371, S0376;
OS Shigella flexneri.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Shigella.
OX NCBI_TaxID=623;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=301 / Serotype 2a;
RX PubMed=12384590; DOI=10.1093/nar/gkf566;
RA Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT through comparison with genomes of Escherichia coli K12 and O157.";
RL Nucleic Acids Res. 30:4432-4441(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT "Complete genome sequence and comparative genomics of Shigella flexneri
RT serotype 2a strain 2457T.";
RL Infect. Immun. 71:2775-2786(2003).
CC -!- FUNCTION: Cytochrome bo(3) ubiquinol terminal oxidase is the component
CC of the aerobic respiratory chain of E.coli that predominates when cells
CC are grown at high aeration. Has proton pump activity across the
CC membrane in addition to electron transfer, pumping 2 protons/electron
CC (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Heterooctamer of two A chains, two B chains, two C chains and
CC two D chains. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the cytochrome c oxidase subunit 3 family.
CC {ECO:0000305}.
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DR EMBL; AE005674; AAN42029.1; -; Genomic_DNA.
DR EMBL; AE014073; AAP15906.1; -; Genomic_DNA.
DR RefSeq; NP_706322.1; NC_004337.2.
DR RefSeq; WP_000179819.1; NZ_WPGW01000189.1.
DR AlphaFoldDB; P0ABJ5; -.
DR SMR; P0ABJ5; -.
DR STRING; 198214.SF0371; -.
DR PRIDE; P0ABJ5; -.
DR EnsemblBacteria; AAN42029; AAN42029; SF0371.
DR EnsemblBacteria; AAP15906; AAP15906; S0376.
DR GeneID; 1027694; -.
DR GeneID; 66671268; -.
DR KEGG; sfl:SF0371; -.
DR KEGG; sfx:S0376; -.
DR PATRIC; fig|198214.7.peg.426; -.
DR HOGENOM; CLU_044071_3_0_6; -.
DR OMA; SIYWWGS; -.
DR OrthoDB; 1502742at2; -.
DR Proteomes; UP000001006; Chromosome.
DR Proteomes; UP000002673; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0009486; F:cytochrome bo3 ubiquinol oxidase activity; IEA:InterPro.
DR GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:InterPro.
DR GO; GO:0019646; P:aerobic electron transport chain; IEA:InterPro.
DR CDD; cd02863; Ubiquinol_oxidase_III; 1.
DR Gene3D; 1.20.120.80; -; 1.
DR InterPro; IPR024791; Cyt_c/ubiquinol_Oxase_su3.
DR InterPro; IPR000298; Cyt_c_oxidase-like_su3.
DR InterPro; IPR035973; Cyt_c_oxidase_su3-like_sf.
DR InterPro; IPR013833; Cyt_c_oxidase_su3_a-hlx.
DR InterPro; IPR014206; Cyt_c_ubiqinol_oxidase_su3.
DR InterPro; IPR033946; Ubiquinol_oxase_su3_dom.
DR PANTHER; PTHR11403; PTHR11403; 1.
DR Pfam; PF00510; COX3; 1.
DR SUPFAM; SSF81452; SSF81452; 1.
DR TIGRFAMs; TIGR02842; CyoC; 1.
DR PROSITE; PS50253; COX3; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Electron transport; Membrane;
KW Oxidoreductase; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..204
FT /note="Cytochrome bo(3) ubiquinol oxidase subunit 3"
FT /id="PRO_0000183895"
FT TOPO_DOM 1..31
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 32..50
FT /note="Helical"
FT /evidence="ECO:0000305"
FT TOPO_DOM 51..66
FT /note="Periplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 67..85
FT /note="Helical"
FT /evidence="ECO:0000305"
FT TOPO_DOM 86..101
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 102..120
FT /note="Helical"
FT /evidence="ECO:0000305"
FT TOPO_DOM 121..142
FT /note="Periplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 143..161
FT /note="Helical"
FT /evidence="ECO:0000305"
FT TOPO_DOM 162..184
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 185..203
FT /note="Helical"
FT /evidence="ECO:0000305"
FT TOPO_DOM 204
FT /note="Periplasmic"
FT /evidence="ECO:0000305"
SQ SEQUENCE 204 AA; 22623 MW; F1D6ABF9EB6CB5AD CRC64;
MATDTLTHAT AHAHEHGHHD AGGTKIFGFW IYLMSDCILF SILFATYAVL VNGTAGGPTG
KDIFELPFVL VETFLLLFSS ITYGMAAIAM YKNNKSQVIS WLALTWLFGA GFIGMEIYEF
HHLIVNGMGP DRSGFLSAFF ALVGTHGLHV TSGLIWMAVL MVQIARRGLT STNRTRIMCL
SLFWHFLDVV WICVFTVVYL MGAM
