CYOD_SHIFL
ID CYOD_SHIFL Reviewed; 109 AA.
AC P0ABJ8; P18403; P77116;
DT 25-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT 25-OCT-2005, sequence version 1.
DT 25-MAY-2022, entry version 96.
DE RecName: Full=Cytochrome bo(3) ubiquinol oxidase subunit 4;
DE AltName: Full=Cytochrome o ubiquinol oxidase subunit 4;
DE Short=Cytochrome o subunit 4;
DE AltName: Full=Oxidase bo(3) subunit 4;
DE AltName: Full=Ubiquinol oxidase chain D;
DE AltName: Full=Ubiquinol oxidase polypeptide IV;
DE AltName: Full=Ubiquinol oxidase subunit 4;
GN Name=cyoD; OrderedLocusNames=SF0370, S0375;
OS Shigella flexneri.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Shigella.
OX NCBI_TaxID=623;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=301 / Serotype 2a;
RX PubMed=12384590; DOI=10.1093/nar/gkf566;
RA Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT through comparison with genomes of Escherichia coli K12 and O157.";
RL Nucleic Acids Res. 30:4432-4441(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT "Complete genome sequence and comparative genomics of Shigella flexneri
RT serotype 2a strain 2457T.";
RL Infect. Immun. 71:2775-2786(2003).
CC -!- FUNCTION: Cytochrome bo(3) ubiquinol terminal oxidase is the component
CC of the aerobic respiratory chain of E.coli that predominates when cells
CC are grown at high aeration. Has proton pump activity across the
CC membrane in addition to electron transfer, pumping 2 protons/electron
CC (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Heterooctamer of two A chains, two B chains, two C chains and
CC two D chains. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the cytochrome c oxidase bacterial subunit 4
CC family. {ECO:0000305}.
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DR EMBL; AE005674; AAN42028.1; -; Genomic_DNA.
DR EMBL; AE014073; AAP15905.1; -; Genomic_DNA.
DR RefSeq; NP_706321.1; NC_004337.2.
DR RefSeq; WP_000019869.1; NZ_WPGW01000189.1.
DR AlphaFoldDB; P0ABJ8; -.
DR SMR; P0ABJ8; -.
DR STRING; 198214.SF0370; -.
DR EnsemblBacteria; AAN42028; AAN42028; SF0370.
DR EnsemblBacteria; AAP15905; AAP15905; S0375.
DR GeneID; 1027659; -.
DR GeneID; 66671269; -.
DR KEGG; sfl:SF0370; -.
DR KEGG; sfx:S0375; -.
DR PATRIC; fig|198214.7.peg.425; -.
DR HOGENOM; CLU_140945_1_0_6; -.
DR OMA; IVVHMVF; -.
DR OrthoDB; 2088013at2; -.
DR Proteomes; UP000001006; Chromosome.
DR Proteomes; UP000002673; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0009486; F:cytochrome bo3 ubiquinol oxidase activity; IEA:InterPro.
DR GO; GO:0015990; P:electron transport coupled proton transport; IEA:InterPro.
DR InterPro; IPR005171; Cyt_c_oxidase_su4_prok.
DR InterPro; IPR014210; Cyt_o_ubiqinol_oxidase_su4.
DR Pfam; PF03626; COX4_pro; 1.
DR TIGRFAMs; TIGR02847; CyoD; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Electron transport; Membrane;
KW Oxidoreductase; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..109
FT /note="Cytochrome bo(3) ubiquinol oxidase subunit 4"
FT /id="PRO_0000183912"
FT TOPO_DOM 1..17
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 18..36
FT /note="Helical"
FT /evidence="ECO:0000305"
FT TOPO_DOM 37..45
FT /note="Periplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 46..64
FT /note="Helical"
FT /evidence="ECO:0000305"
FT TOPO_DOM 65..80
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 81..99
FT /note="Helical"
FT /evidence="ECO:0000305"
FT TOPO_DOM 100..109
FT /note="Periplasmic"
FT /evidence="ECO:0000305"
SQ SEQUENCE 109 AA; 12029 MW; E2DBE23C893724BA CRC64;
MSHSTDHSGA SHGSVKTYMT GFILSIILTV IPFWMVMTGA ASPAVILGTI LAMAVVQVLV
HLVCFLHMNT KSDEGWNMTA FVFTVLIIAI LVVGSIWIMW NLNYNMMMH
