ID   CYP11_CAEEL             Reviewed;         183 AA.
AC   P52018;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 130.
DE   RecName: Full=Peptidyl-prolyl cis-trans isomerase 11;
DE            Short=PPIase 11;
DE            EC=5.2.1.8;
DE   AltName: Full=Cyclophilin-11;
DE   AltName: Full=Rotamase 11;
GN   Name=cyn-11; Synonyms=cyp-11; ORFNames=T01B7.4;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Bristol N2;
RX   PubMed=8694762; DOI=10.1042/bj3170179;
RA   Page A.P., Macniven K., Hengartner M.O.;
RT   "Cloning and biochemical characterization of the cyclophilin homologues
RT   from the free-living nematode Caenorhabditis elegans.";
RL   Biochem. J. 317:179-185(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: PPIases accelerate the folding of proteins. It catalyzes the
CC       cis-trans isomerization of proline imidic peptide bonds in
CC       oligopeptides.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[protein]-peptidylproline (omega=180) = [protein]-
CC         peptidylproline (omega=0); Xref=Rhea:RHEA:16237, Rhea:RHEA-
CC         COMP:10747, Rhea:RHEA-COMP:10748, ChEBI:CHEBI:83833,
CC         ChEBI:CHEBI:83834; EC=5.2.1.8;
CC   -!- SIMILARITY: Belongs to the cyclophilin-type PPIase family. PPIase H
CC       subfamily. {ECO:0000305}.
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DR   EMBL; U34955; AAC47115.1; -; mRNA.
DR   EMBL; Z66499; CAA91297.1; -; Genomic_DNA.
DR   PIR; T18578; T18578.
DR   RefSeq; NP_495855.1; NM_063454.5.
DR   AlphaFoldDB; P52018; -.
DR   SMR; P52018; -.
DR   BioGRID; 39721; 1.
DR   STRING; 6239.T01B7.4; -.
DR   EPD; P52018; -.
DR   PaxDb; P52018; -.
DR   PeptideAtlas; P52018; -.
DR   EnsemblMetazoa; T01B7.4.1; T01B7.4.1; WBGene00000887.
DR   GeneID; 174394; -.
DR   KEGG; cel:CELE_T01B7.4; -.
DR   UCSC; T01B7.4; c. elegans.
DR   CTD; 174394; -.
DR   WormBase; T01B7.4; CE03588; WBGene00000887; cyn-11.
DR   eggNOG; KOG0879; Eukaryota.
DR   GeneTree; ENSGT00940000154721; -.
DR   HOGENOM; CLU_012062_4_3_1; -.
DR   InParanoid; P52018; -.
DR   OMA; RHPNNPV; -.
DR   OrthoDB; 1403619at2759; -.
DR   PhylomeDB; P52018; -.
DR   Reactome; R-CEL-72163; mRNA Splicing - Major Pathway.
DR   PRO; PR:P52018; -.
DR   Proteomes; UP000001940; Chromosome II.
DR   Bgee; WBGene00000887; Expressed in embryo and 4 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR   GO; GO:0016018; F:cyclosporin A binding; IBA:GO_Central.
DR   GO; GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IBA:GO_Central.
DR   GO; GO:0006457; P:protein folding; IBA:GO_Central.
DR   GO; GO:0000413; P:protein peptidyl-prolyl isomerization; IBA:GO_Central.
DR   Gene3D; 2.40.100.10; -; 1.
DR   InterPro; IPR029000; Cyclophilin-like_dom_sf.
DR   InterPro; IPR024936; Cyclophilin-type_PPIase.
DR   InterPro; IPR020892; Cyclophilin-type_PPIase_CS.
DR   InterPro; IPR002130; Cyclophilin-type_PPIase_dom.
DR   Pfam; PF00160; Pro_isomerase; 1.
DR   PIRSF; PIRSF001467; Peptidylpro_ismrse; 1.
DR   PRINTS; PR00153; CSAPPISMRASE.
DR   SUPFAM; SSF50891; SSF50891; 1.
DR   PROSITE; PS00170; CSA_PPIASE_1; 1.
DR   PROSITE; PS50072; CSA_PPIASE_2; 1.
PE   2: Evidence at transcript level;
KW   Isomerase; Reference proteome; Rotamase.
FT   CHAIN           1..183
FT                   /note="Peptidyl-prolyl cis-trans isomerase 11"
FT                   /id="PRO_0000064198"
FT   DOMAIN          20..182
FT                   /note="PPIase cyclophilin-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00156"
SQ   SEQUENCE   183 AA;  20193 MW;  23549C922828C533 CRC64;
     MTEYDKFAEQ LRHPDNPIVF LEVTAGGAPI GTIVIELFAD VTPRTAENFR QFCTGEYKKD
     GVPNGYKNCT FHRVIKDFMI QGGDFCNGDG TGLMSIYGSK FRDENFELKH IGPGMLSMAN
     AGSDTNGCQF FITCAKTDFL DNKHVVFGRV LDGMLTVRKI ENVPTGANNK PKLPIVVVQC
     GQL