ID   CYPC_STRCO              Reviewed;         159 AA.
AC   P23154;
DT   01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1991, sequence version 1.
DT   25-MAY-2022, entry version 105.
DE   RecName: Full=Putative polyketide cyclase;
DE   AltName: Full=WhiE ORF VI;
GN   OrderedLocusNames=SCO5315; ORFNames=SC6G9.18;
OS   Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces; Streptomyces albidoflavus group.
OX   NCBI_TaxID=100226;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=A3(2) / NRRL B-16638;
RX   PubMed=2077356; DOI=10.1111/j.1365-2958.1990.tb00545.x;
RA   Davis N.K., Chater K.F., Bruton C.J.;
RT   "Spore colour in Streptomyces coelicolor A3(2) involves the developmentally
RT   regulated synthesis of a compound biosynthetically related to polyketide
RT   antibiotics.";
RL   Mol. Microbiol. 4:1679-1691(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-471 / A3(2) / M145;
RX   PubMed=12000953; DOI=10.1038/417141a;
RA   Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L.,
RA   Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D.,
RA   Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A.,
RA   Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.-H.,
RA   Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E.,
RA   Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D.,
RA   Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A.,
RA   Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A.;
RT   "Complete genome sequence of the model actinomycete Streptomyces coelicolor
RT   A3(2).";
RL   Nature 417:141-147(2002).
CC   -!- FUNCTION: Involved in developmentally regulated synthesis of a compound
CC       biosynthetically related to polyketide antibiotics which is essential
CC       for spore color in Streptomyces coelicolor.
CC   -!- SIMILARITY: To polyketide cyclases. {ECO:0000305}.
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DR   EMBL; X55942; CAA39411.1; -; Genomic_DNA.
DR   EMBL; AL939123; CAB45609.1; -; Genomic_DNA.
DR   PIR; T35614; T35614.
DR   RefSeq; NP_629457.1; NC_003888.3.
DR   RefSeq; WP_003973657.1; NZ_VNID01000040.1.
DR   PDB; 2KF2; NMR; -; A=1-159.
DR   PDB; 3TL1; X-ray; 1.80 A; A/B=1-159.
DR   PDB; 3TVR; X-ray; 1.80 A; A=1-159.
DR   PDBsum; 2KF2; -.
DR   PDBsum; 3TL1; -.
DR   PDBsum; 3TVR; -.
DR   AlphaFoldDB; P23154; -.
DR   BMRB; P23154; -.
DR   SMR; P23154; -.
DR   STRING; 100226.SCO5315; -.
DR   GeneID; 1100755; -.
DR   KEGG; sco:SCO5315; -.
DR   PATRIC; fig|100226.15.peg.5401; -.
DR   eggNOG; COG2867; Bacteria.
DR   HOGENOM; CLU_1651183_0_0_11; -.
DR   OMA; IQDFAMK; -.
DR   PhylomeDB; P23154; -.
DR   EvolutionaryTrace; P23154; -.
DR   Proteomes; UP000001973; Chromosome.
DR   Gene3D; 3.30.530.20; -; 1.
DR   InterPro; IPR005031; COQ10_START.
DR   InterPro; IPR023393; START-like_dom_sf.
DR   Pfam; PF03364; Polyketide_cyc; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Reference proteome.
FT   CHAIN           1..159
FT                   /note="Putative polyketide cyclase"
FT                   /id="PRO_0000079757"
FT   STRAND          3..13
FT                   /evidence="ECO:0007829|PDB:3TL1"
FT   HELIX           15..22
FT                   /evidence="ECO:0007829|PDB:3TL1"
FT   HELIX           25..27
FT                   /evidence="ECO:0007829|PDB:3TL1"
FT   HELIX           28..31
FT                   /evidence="ECO:0007829|PDB:3TL1"
FT   STRAND          33..43
FT                   /evidence="ECO:0007829|PDB:3TL1"
FT   STRAND          45..54
FT                   /evidence="ECO:0007829|PDB:3TL1"
FT   STRAND          64..72
FT                   /evidence="ECO:0007829|PDB:3TL1"
FT   TURN            73..76
FT                   /evidence="ECO:0007829|PDB:3TL1"
FT   STRAND          77..84
FT                   /evidence="ECO:0007829|PDB:3TL1"
FT   STRAND          88..100
FT                   /evidence="ECO:0007829|PDB:3TL1"
FT   STRAND          103..114
FT                   /evidence="ECO:0007829|PDB:3TL1"
FT   STRAND          118..120
FT                   /evidence="ECO:0007829|PDB:3TVR"
FT   HELIX           122..157
FT                   /evidence="ECO:0007829|PDB:3TL1"
SQ   SEQUENCE   159 AA;  18197 MW;  EBEAD2FCCAB23A43 CRC64;
     MAGHTDNEIT IAAPMELVWN MTNDIEKWPG LFSEYASVEV LGRDDDKVTF RLTMHPDADG
     KVWSWVSERV ADPVTRTVRA QRVETGPFQY MNIVWEYAET AEGTVMRWTQ DFAMKPDAPV
     DDAWMTDNIN RNSRTQMALI RDRIEQAAGE RRTASVLAD