ID   CYPK_STRCM              Reviewed;         304 AA.
AC   P41178;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   25-MAY-2022, entry version 47.
DE   RecName: Full=Granaticin polyketide synthase bifunctional cyclase/dehydratase;
DE   AltName: Full=ORF4;
OS   Streptomyces cinnamonensis.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces; Streptomyces virginiae group.
OX   NCBI_TaxID=1900;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=A3823.5;
RX   PubMed=1508151; DOI=10.1007/bf00283846;
RA   Arrowsmith T.J., Malpartida F., Sherman D.H., Birch A., Hopwood D.A.,
RA   Robinson J.A.;
RT   "Characterisation of actI-homologous DNA encoding polyketide synthase genes
RT   from the monensin producer Streptomyces cinnamonensis.";
RL   Mol. Gen. Genet. 234:254-264(1992).
CC   -!- FUNCTION: Is needed for correct cyclization of the oligoketide leading
CC       to isochromanequinone formation.
CC   -!- PATHWAY: Antifungal biosynthesis; monensin biosynthesis.
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DR   EMBL; Z11511; CAA77600.1; -; Genomic_DNA.
DR   PIR; S25080; S25080.
DR   AlphaFoldDB; P41178; -.
DR   SMR; P41178; -.
DR   UniPathway; UPA00178; -.
DR   GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.530.20; -; 2.
DR   InterPro; IPR005031; COQ10_START.
DR   InterPro; IPR023393; START-like_dom_sf.
DR   Pfam; PF03364; Polyketide_cyc; 1.
PE   4: Predicted;
KW   Antibiotic biosynthesis.
FT   CHAIN           1..304
FT                   /note="Granaticin polyketide synthase bifunctional
FT                   cyclase/dehydratase"
FT                   /id="PRO_0000079759"
SQ   SEQUENCE   304 AA;  33822 MW;  E8930CDACC3C8D67 CRC64;
     MTTRQVEHEY TIGAPAATVY RLLADVSHWP QIFPPTIHVE RQATGAHQER IHIWATANGQ
     AKNWTSRRTL DPEALRIDSA SEVTTAPVAA MGGTWIVEPL GADSSRIRLL HDSGPSPRPQ
     DLQWIDRAVD TTRHLELAAL ATTSNHAHAA EERELLSFTD TCTIDGAAKD VFDFVNEADR
     WPERLPHVAT VRFEEPAPGL QILEMDTRAK DGSVHTTKSY RVALDTRKIA YKQVTLPALM
     TLHTGVWTFT RRPGHHRGEL AAHRLHQHAN IAKIPRRAGQ VADARDYVHS ALSTNSRAPW
     ASQG