ID   CYPK_STRCO              Reviewed;         316 AA.
AC   Q02055;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=Actinorhodin polyketide synthase bifunctional cyclase/dehydratase;
DE   AltName: Full=ACTVII;
DE   AltName: Full=actI ORF4;
GN   OrderedLocusNames=SCO5090; ORFNames=SCBAC28G1.16;
OS   Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces; Streptomyces albidoflavus group.
OX   NCBI_TaxID=100226;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC BAA-471 / A3(2) / M145;
RX   PubMed=1527048; DOI=10.1016/s0021-9258(18)41772-3;
RA   Fernandez-Moreno M.A., Martinez E., Boto L., Hopwood D.A., Malpartida F.;
RT   "Nucleotide sequence and deduced functions of a set of cotranscribed genes
RT   of Streptomyces coelicolor A3(2) including the polyketide synthase for the
RT   antibiotic actinorhodin.";
RL   J. Biol. Chem. 267:19278-19290(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-471 / A3(2) / M145;
RX   PubMed=12000953; DOI=10.1038/417141a;
RA   Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L.,
RA   Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D.,
RA   Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A.,
RA   Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.-H.,
RA   Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E.,
RA   Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D.,
RA   Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A.,
RA   Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A.;
RT   "Complete genome sequence of the model actinomycete Streptomyces coelicolor
RT   A3(2).";
RL   Nature 417:141-147(2002).
CC   -!- FUNCTION: Is needed for correct cyclization of the oligoketide leading
CC       to isochromanequinone formation.
CC   -!- PATHWAY: Antibiotic biosynthesis; actinorhodin biosynthesis.
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DR   EMBL; X63449; CAA45046.1; -; Genomic_DNA.
DR   EMBL; AL939122; CAC44203.1; -; Genomic_DNA.
DR   PIR; S25843; S25843.
DR   RefSeq; NP_629240.1; NC_003888.3.
DR   RefSeq; WP_011030049.1; NZ_VNID01000008.1.
DR   AlphaFoldDB; Q02055; -.
DR   SMR; Q02055; -.
DR   STRING; 100226.SCO5090; -.
DR   GeneID; 1100531; -.
DR   KEGG; sco:SCO5090; -.
DR   PATRIC; fig|100226.15.peg.5170; -.
DR   eggNOG; COG2867; Bacteria.
DR   HOGENOM; CLU_049174_0_0_11; -.
DR   OMA; KNWTSRR; -.
DR   PhylomeDB; Q02055; -.
DR   UniPathway; UPA00173; -.
DR   Proteomes; UP000001973; Chromosome.
DR   GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.530.20; -; 2.
DR   InterPro; IPR005031; COQ10_START.
DR   InterPro; IPR023393; START-like_dom_sf.
DR   Pfam; PF03364; Polyketide_cyc; 1.
PE   4: Predicted;
KW   Antibiotic biosynthesis; Reference proteome.
FT   CHAIN           1..316
FT                   /note="Actinorhodin polyketide synthase bifunctional
FT                   cyclase/dehydratase"
FT                   /id="PRO_0000079760"
SQ   SEQUENCE   316 AA;  34665 MW;  E9C946F9A0FD23D3 CRC64;
     MSRPGEHRVV HTLRTQAPAR RLYELVARVE DWPAVFEPTV HVQVLERGPG TERFRIWARV
     GGRVKTWTSR RTLDPDTLRV TFRQELTQPP IASMGGSWEF RGDGDGTEVV LTHDFAAVDE
     AALPGLREAL DANSGKELAA LVALAERRQP PEELVFTFED TLRVPSGDDA YAFIERSDLW
     QERLPHVRKV TLTEEAAGTG PAETRDMTVQ DMTMETVTTD GGTHTTRSIR LCVPARSIVY
     KQLVPPALLS GHCGAWTFGE DTVTARHTVA IDPARVEEVL GKGATVADAR THLREVLGAN
     SRATLRHAAA AAGPAS