ID   CYPK_STRVN              Reviewed;         324 AA.
AC   P16560;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1990, sequence version 1.
DT   25-MAY-2022, entry version 64.
DE   RecName: Full=Granaticin polyketide synthase bifunctional cyclase/dehydratase;
GN   Name=gra-orf4;
OS   Streptomyces violaceoruber.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=1935;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Tu22;
RX   PubMed=2583128; DOI=10.1002/j.1460-2075.1989.tb08413.x;
RA   Sherman D.H., Malpartida F., Bibb M.J., Kieser H.M., Bibb M.J.,
RA   Hopwood D.A.;
RT   "Structure and deduced function of the granaticin-producing polyketide
RT   synthase gene cluster of Streptomyces violaceoruber Tu22.";
RL   EMBO J. 8:2717-2725(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Tu22;
RX   PubMed=7476861; DOI=10.1007/bf02423457;
RA   Bechthold A., Sohng J.K., Smith T.M., Chu X., Floss H.G.;
RT   "Identification of Streptomyces violaceoruber Tu22 genes involved in the
RT   biosynthesis of granaticin.";
RL   Mol. Gen. Genet. 248:610-620(1995).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Tu22;
RX   PubMed=9831526; DOI=10.1016/s1074-5521(98)90292-7;
RA   Ichinose K., Bedford D.J., Tornus D., Bechthold A., Bibb M.J., Revill W.P.,
RA   Floss H.G., Hopwood D.A.;
RT   "The granaticin biosynthetic gene cluster of Streptomyces violaceoruber
RT   Tu22: sequence analysis and expression in a heterologous host.";
RL   Chem. Biol. 5:647-659(1998).
CC   -!- FUNCTION: Is needed for correct cyclization of the oligoketide leading
CC       to isochromanequinone formation.
CC   -!- PATHWAY: Antibiotic biosynthesis; granaticin biosynthesis.
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DR   EMBL; X16300; CAA34372.1; -; Genomic_DNA.
DR   EMBL; X16144; CAA34267.1; -; Genomic_DNA.
DR   EMBL; AJ011500; CAA09656.1; -; Genomic_DNA.
DR   PIR; S05396; S05396.
DR   AlphaFoldDB; P16560; -.
DR   SMR; P16560; -.
DR   UniPathway; UPA00175; -.
DR   GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.530.20; -; 2.
DR   InterPro; IPR019587; Polyketide_cyclase/dehydratase.
DR   InterPro; IPR023393; START-like_dom_sf.
DR   Pfam; PF10604; Polyketide_cyc2; 1.
PE   4: Predicted;
KW   Antibiotic biosynthesis.
FT   CHAIN           1..324
FT                   /note="Granaticin polyketide synthase bifunctional
FT                   cyclase/dehydratase"
FT                   /id="PRO_0000079761"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..20
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   324 AA;  35673 MW;  4893A828DD1CB075 CRC64;
     MVQPAATPVS LPSPTVHRSE HTVTVAAPPE ALYALVADVT RWPAVFEPTV HVRHLAREGR
     TERFEIWAEV NGEIAHWRSR RVLDPVRRYV SFRQEHSRPP VTSMSGGWLF RPLADGRTEI
     VLRHRFTVAD DDPAAVARIE EALDRNSARE LGALAALAET GHPVDELVFS FTDTLPLQGA
     ARDAYTFVER AERWAELLPH VAQCGADRAG TGLEQWLEMD TVTADGSTHT TRSARICRAP
     EWIAYNEQRT PRLVSGHSGE WTFAQTPEGP VATARHTVAV DPSGITEVLG PDATLADARA
     YLRDALGRNS LATLRHAAEA AQRA