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CYPR1_CYNCA
ID   CYPR1_CYNCA             Reviewed;         473 AA.
AC   P40782;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 2.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Cyprosin;
DE            EC=3.4.23.-;
DE   Flags: Precursor; Fragment;
GN   Name=CYPRO1;
OS   Cynara cardunculus (Cardoon).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; campanulids; Asterales; Asteraceae; Carduoideae; Cardueae;
OC   Carduinae; Cynara.
OX   NCBI_TaxID=4265;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 178-186.
RC   TISSUE=Flower bud;
RX   PubMed=8193298; DOI=10.1007/bf00029855;
RA   Cordeiro M.C., Xue Z.-T., Pietrzak M., Pais M.S., Brodelius P.E.;
RT   "Isolation and characterization of a cDNA from flowers of Cynara
RT   cardunculus encoding cyprosin (an aspartic proteinase) and its use to study
RT   the organ-specific expression of cyprosin.";
RL   Plant Mol. Biol. 24:733-741(1994).
CC   -!- TISSUE SPECIFICITY: Mostly present in the violet parts of styles and
CC       corollas of mature flowers.
CC   -!- DEVELOPMENTAL STAGE: Expressed in early stages of floral development
CC       and switched off at maturation of the flower.
CC   -!- SIMILARITY: Belongs to the peptidase A1 family. {ECO:0000305}.
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DR   EMBL; X69193; CAA48939.1; ALT_SEQ; mRNA.
DR   PIR; S47096; S47096.
DR   PIR; T12049; T12049.
DR   AlphaFoldDB; P40782; -.
DR   SMR; P40782; -.
DR   MEROPS; A01.A02; -.
DR   PRIDE; P40782; -.
DR   GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd06098; phytepsin; 1.
DR   Gene3D; 2.40.70.10; -; 2.
DR   InterPro; IPR001461; Aspartic_peptidase_A1.
DR   InterPro; IPR001969; Aspartic_peptidase_AS.
DR   InterPro; IPR033121; PEPTIDASE_A1.
DR   InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR   InterPro; IPR033869; Phytepsin.
DR   InterPro; IPR007856; SapB_1.
DR   InterPro; IPR008138; SapB_2.
DR   InterPro; IPR011001; Saposin-like.
DR   InterPro; IPR008139; SaposinB_dom.
DR   PANTHER; PTHR47966; PTHR47966; 1.
DR   Pfam; PF00026; Asp; 1.
DR   Pfam; PF05184; SapB_1; 1.
DR   Pfam; PF03489; SapB_2; 1.
DR   PRINTS; PR00792; PEPSIN.
DR   SMART; SM00741; SapB; 1.
DR   SUPFAM; SSF47862; SSF47862; 1.
DR   SUPFAM; SSF50630; SSF50630; 1.
DR   PROSITE; PS00141; ASP_PROTEASE; 2.
DR   PROSITE; PS51767; PEPTIDASE_A1; 1.
DR   PROSITE; PS50015; SAP_B; 2.
PE   1: Evidence at protein level;
KW   Aspartyl protease; Direct protein sequencing; Disulfide bond; Glycoprotein;
KW   Hydrolase; Protease; Zymogen.
FT   PROPEP          <1..33
FT                   /note="Activation peptide"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000025899"
FT   CHAIN           34..473
FT                   /note="Cyprosin"
FT                   /id="PRO_0000025900"
FT   DOMAIN          51..470
FT                   /note="Peptidase A1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01103"
FT   DOMAIN          281..384
FT                   /note="Saposin B-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00415"
FT   ACT_SITE        69
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10094"
FT   ACT_SITE        256
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10094"
FT   CARBOHYD        364
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00415"
FT   DISULFID        82..88
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00415"
FT   DISULFID        247..251
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00415"
FT   DISULFID        286..378
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00415"
FT   DISULFID        311..350
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00415"
FT   DISULFID        317..347
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00415"
FT   DISULFID        392..429
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00415"
FT   NON_TER         1
SQ   SEQUENCE   473 AA;  51564 MW;  65F3232EBD06CB56 CRC64;
     LKKRKVNILN HPGEHAGSND ANARRKYGVR GNFRDSDGEL IALKNYMDAQ YFGEIGIGTP
     PQKFTVIFDT GSSNLWVPSS KCYFSVACLF HSKYRSTDST TYKKNGKSAA IQYGTGSISG
     FFSQDSVKLG DLLVKEQDFI EATKEPGITF LAAKFDGILG LGFQEISVGD AVPVWYTMLN
     QGLVQEPVFS FWLNRNADEQ EGGELVFGGV DPNHFKGEHT YVPVTQKGYW QFEMGDVLIG
     DKTTGFCASG CAAIADSGTS LLAGTTTIVT QINQAIGAAG VMSQQCKSLV DQYGKSMIEM
     LLSEEQPEKI CSQMKLCSFD GSHDTSMIIE SVVDKSKGKS SGLPMRCVPC ARWVVWMQNQ
     IRQNETEENI INYVDKLCER LPSPMGESAV DCSSLSSMPN IAFTVGGKTF NLSPEQYVLK
     VGEGATAQCI SGFTAMDVAP PHGPLWILGD VFMGQYHTVF DYGNLRVGFA EAA
 
 
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