CYPT1_MOUSE
ID CYPT1_MOUSE Reviewed; 168 AA.
AC Q8CH20; B1AX51; Q3MSD0; Q3MSD1; Q6P8T4; Q9D4K2; Q9D9I2;
DT 22-NOV-2017, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=Cysteine-rich perinuclear theca protein 1 {ECO:0000303|PubMed:15286030};
GN Name=Cypt1 {ECO:0000303|PubMed:15286030};
GN Synonyms=Ckt1r3 {ECO:0000312|MGI:MGI:3616441},
GN Cypt5 {ECO:0000312|MGI:MGI:3616441};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000312|EMBL:CAJ13846.1}
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), SUBCELLULAR LOCATION, TISSUE
RP SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC STRAIN=C3H/He {ECO:0000312|EMBL:CAJ13846.1};
RC TISSUE=Testis {ECO:0000312|EMBL:CAJ13846.1};
RX PubMed=15286030; DOI=10.1095/biolreprod.104.032789;
RA Kitamura K., Iguchi N., Kaneko Y., Tanaka H., Nishimune Y.;
RT "Characterization of a novel postacrosomal perinuclear theca-specific
RT protein, CYPT1.";
RL Biol. Reprod. 71:1927-1935(2004).
RN [2] {ECO:0000312|EMBL:CAJ13850.1}
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC STRAIN=C3H/He {ECO:0000312|EMBL:CAJ13850.1};
RC TISSUE=Testis {ECO:0000312|EMBL:CAJ13850.1};
RX PubMed=16477651; DOI=10.1002/mrd.20463;
RA Hansen M.A., Nielsen J.E., Tanaka M., Almstrup K., Skakkebaek N.E.,
RA Leffers H.;
RT "Identification and expression profiling of 10 novel spermatid expressed
RT CYPT genes.";
RL Mol. Reprod. Dev. 73:568-579(2006).
RN [3] {ECO:0000312|EMBL:AAO15675.1}
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC STRAIN=CD-1 {ECO:0000312|EMBL:AAO15675.1};
RC TISSUE=Testis {ECO:0000312|EMBL:AAO15675.1};
RA Xu X., Bai X., Silvius D., Escalier D., McFarland L., Xu P.-X.;
RT "Ck2 differentially phosphorylate a family of novel spermatid-specific
RT basic nuclear proteins.";
RL Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000312|EMBL:BAB30253.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:BAB30253.1};
RC TISSUE=Testis {ECO:0000312|EMBL:BAB30253.1};
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [5] {ECO:0000312|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000312|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [6] {ECO:0000312|EMBL:EDL35714.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [7] {ECO:0000312|EMBL:AAH61079.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Testis {ECO:0000312|EMBL:AAH61079.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, perinuclear theca
CC {ECO:0000269|PubMed:15286030}. Note=Found in the postacrosomal region
CC of the perinuclear theca. {ECO:0000269|PubMed:15286030}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8CH20-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8CH20-2; Sequence=VSP_059219;
CC -!- TISSUE SPECIFICITY: Specifically expressed in spermatozoa (at protein
CC level). Detected from the elongated spermatid stage onwards; not found
CC in immature germ cells or somatic cells (at protein level).
CC {ECO:0000269|PubMed:15286030}.
CC -!- DEVELOPMENTAL STAGE: Detected from 29 days postpartum onwards, with
CC increasing expression through to the adult stage.
CC {ECO:0000269|PubMed:15286030}.
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DR EMBL; AM040451; CAJ13846.1; -; mRNA.
DR EMBL; AM040454; CAJ13849.1; -; mRNA.
DR EMBL; AM040455; CAJ13850.1; -; mRNA.
DR EMBL; AF463502; AAO15675.1; -; mRNA.
DR EMBL; AK006892; BAB24782.1; -; mRNA.
DR EMBL; AK016467; BAB30253.1; -; mRNA.
DR EMBL; AL805907; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466584; EDL35714.1; -; Genomic_DNA.
DR EMBL; CH466584; EDL35715.1; -; Genomic_DNA.
DR EMBL; BC061079; AAH61079.1; -; mRNA.
DR CCDS; CCDS40880.1; -. [Q8CH20-2]
DR CCDS; CCDS81101.1; -. [Q8CH20-1]
DR RefSeq; NP_001297390.1; NM_001310461.1. [Q8CH20-1]
DR RefSeq; NP_080014.2; NM_025738.3. [Q8CH20-2]
DR AlphaFoldDB; Q8CH20; -.
DR SMR; Q8CH20; -.
DR STRING; 10090.ENSMUSP00000024026; -.
DR SwissPalm; Q8CH20; -.
DR PRIDE; Q8CH20; -.
DR DNASU; 66742; -.
DR Ensembl; ENSMUST00000024026; ENSMUSP00000024026; ENSMUSG00000023257. [Q8CH20-2]
DR Ensembl; ENSMUST00000115422; ENSMUSP00000111082; ENSMUSG00000023257. [Q8CH20-1]
DR GeneID; 66742; -.
DR KEGG; mmu:66742; -.
DR CTD; 66742; -.
DR MGI; MGI:3616441; Cypt1.
DR VEuPathDB; HostDB:ENSMUSG00000023257; -.
DR GeneTree; ENSGT00390000016779; -.
DR HOGENOM; CLU_1585937_0_0_1; -.
DR OrthoDB; 1814430at2759; -.
DR TreeFam; TF339928; -.
DR BioGRID-ORCS; 66742; 2 hits in 72 CRISPR screens.
DR PRO; PR:Q8CH20; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; Q8CH20; protein.
DR Bgee; ENSMUSG00000023257; Expressed in spermatid and 6 other tissues.
DR Genevisible; Q6P8T4; MM.
DR GO; GO:0001669; C:acrosomal vesicle; IDA:MGI.
DR GO; GO:0033011; C:perinuclear theca; IEA:UniProtKB-SubCell.
PE 1: Evidence at protein level;
KW Alternative splicing; Cytoplasm; Cytoskeleton; Reference proteome.
FT CHAIN 1..168
FT /note="Cysteine-rich perinuclear theca protein 1"
FT /id="PRO_0000442286"
FT REGION 144..168
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 91
FT /note="L -> LKVRDP (in isoform 2)"
FT /id="VSP_059219"
FT CONFLICT 71
FT /note="Y -> H (in Ref. 4; BAB24782)"
FT /evidence="ECO:0000305"
FT CONFLICT 85
FT /note="F -> S (in Ref. 2; CAJ13850)"
FT /evidence="ECO:0000305"
FT CONFLICT 116
FT /note="Q -> K (in Ref. 2; CAJ13849)"
FT /evidence="ECO:0000305"
FT CONFLICT 130
FT /note="P -> S (in Ref. 7; AAH61079)"
FT /evidence="ECO:0000305"
FT CONFLICT 132
FT /note="E -> A (in Ref. 2; CAJ13850)"
FT /evidence="ECO:0000305"
FT CONFLICT Q8CH20-2:92
FT /note="K -> R (in Ref. 1; CAJ13846 and 4; BAB30253)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 168 AA; 18957 MW; 8F30D3D27B9BF595 CRC64;
MAQMAKKVHW SSAAAGAAAA AKISKLEKTT KRFKLIKKRN PSSKLPKRSS HSLLCSLSRS
CCCCRCRCCC YCRCCRCCCS RSRRFRSRTT LKFFQITEKG EQSLQRRIRR QLTRSQLELI
EPEPTMALEP SEITVAFFSH KNANVSDPEE VPPCLDSDPF PNGDLASS
