ID   CYRIA_CHICK             Reviewed;         323 AA.
AC   Q5ZI04;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=CYFIP-related Rac1 interactor A;
GN   Name=CYRIA; Synonyms=FAM49A; ORFNames=RCJMB04_31l4;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: May negatively regulate RAC1 signaling and RAC1-driven
CC       cytoskeletal remodeling. May regulate chemotaxis, cell migration and
CC       epithelial polarization by controlling the polarity, plasticity,
CC       duration and extent of protrusions. {ECO:0000250|UniProtKB:Q9H0Q0}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q9NUQ9}; Lipid-
CC       anchor {ECO:0000250|UniProtKB:Q9NUQ9}.
CC   -!- SIMILARITY: Belongs to the CYRI family. {ECO:0000305}.
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DR   EMBL; AJ720980; CAG32639.1; -; mRNA.
DR   RefSeq; NP_001006418.1; NM_001006418.2.
DR   RefSeq; XP_015131540.1; XM_015276054.1.
DR   RefSeq; XP_015131541.1; XM_015276055.1.
DR   RefSeq; XP_015131542.1; XM_015276056.1.
DR   AlphaFoldDB; Q5ZI04; -.
DR   SMR; Q5ZI04; -.
DR   STRING; 9031.ENSGALP00000026511; -.
DR   PaxDb; Q5ZI04; -.
DR   Ensembl; ENSGALT00000026562; ENSGALP00000026511; ENSGALG00000016463.
DR   Ensembl; ENSGALT00000082144; ENSGALP00000058398; ENSGALG00000016463.
DR   Ensembl; ENSGALT00000095007; ENSGALP00000074038; ENSGALG00000016463.
DR   GeneID; 421949; -.
DR   KEGG; gga:421949; -.
DR   CTD; 378872; -.
DR   VEuPathDB; HostDB:geneid_421949; -.
DR   eggNOG; KOG3951; Eukaryota.
DR   GeneTree; ENSGT00390000015159; -.
DR   HOGENOM; CLU_056470_0_0_1; -.
DR   InParanoid; Q5ZI04; -.
DR   PhylomeDB; Q5ZI04; -.
DR   TreeFam; TF314541; -.
DR   PRO; PR:Q5ZI04; -.
DR   Proteomes; UP000000539; Chromosome 3.
DR   Bgee; ENSGALG00000016463; Expressed in spleen and 14 other tissues.
DR   ExpressionAtlas; Q5ZI04; baseline and differential.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0030833; P:regulation of actin filament polymerization; IEA:InterPro.
DR   InterPro; IPR039789; CYRI.
DR   InterPro; IPR009828; CYRIA/CYRIB_Rac1-bd.
DR   PANTHER; PTHR12422; PTHR12422; 1.
DR   Pfam; PF07159; DUF1394; 1.
PE   2: Evidence at transcript level;
KW   Lipoprotein; Membrane; Reference proteome.
FT   CHAIN           1..323
FT                   /note="CYFIP-related Rac1 interactor A"
FT                   /id="PRO_0000291882"
SQ   SEQUENCE   323 AA;  37314 MW;  9E879E1020802EDF CRC64;
     MGNLLKVLTR EIENYPHFFL DFENAQPTDG EREVWNQISA VLQDSESMLA DLQAYKGAGQ
     EIRDAIQNPN DIQLQEKAWN SVCPLVVRLK RFYEFSLRLE KALQSLLESL TCPPYTPTQH
     LEREQALAKE FAEILHFTLR FDELKMRNPA IQNDFSYYRR TISRNRINNM HLDIENEVNN
     EMANRMSLFY AEATPMLKTL SNATTHFVSE NKTLPIENTT DCLSTMASVC KVMLETPEYR
     SRFTSEETLM FCMRVMVGVI ILYDHVHPVG AFSKTSKIDM KGCIKVLKEQ PPDTVEGLLN
     ALRFTTKHLN DESTSKQIRA MLQ