CYRIA_HUMAN
ID CYRIA_HUMAN Reviewed; 323 AA.
AC Q9H0Q0; B3KNZ1; Q53QW2;
DT 27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=CYFIP-related Rac1 interactor A {ECO:0000305};
DE AltName: Full=Protein CYRIA;
GN Name=CYRIA {ECO:0000303|PubMed:30250061, ECO:0000312|HGNC:HGNC:25373};
GN Synonyms=FAM49A;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RX PubMed=11230166; DOI=10.1101/gr.gr1547r;
RA Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S.,
RA Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J.,
RA Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W.,
RA Ottenwaelder B., Obermaier B., Tampe J., Heubner D., Wambutt R., Korn B.,
RA Klein M., Poustka A.;
RT "Towards a catalog of human genes and proteins: sequencing and analysis of
RT 500 novel complete protein coding human cDNAs.";
RL Genome Res. 11:422-435(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, and Placenta;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP FUNCTION.
RX PubMed=30250061; DOI=10.1038/s41556-018-0198-9;
RA Fort L., Batista J.M., Thomason P.A., Spence H.J., Whitelaw J.A.,
RA Tweedy L., Greaves J., Martin K.J., Anderson K.I., Brown P., Lilla S.,
RA Neilson M.P., Tafelmeyer P., Zanivan S., Ismail S., Bryant D.M.,
RA Tomkinson N.C.O., Chamberlain L.H., Mastick G.S., Insall R.H.,
RA Machesky L.M.;
RT "Fam49/CYRI interacts with Rac1 and locally suppresses protrusions.";
RL Nat. Cell Biol. 20:1159-1171(2018).
CC -!- FUNCTION: May negatively regulate RAC1 signaling and RAC1-driven
CC cytoskeletal remodeling (Probable). May regulate chemotaxis, cell
CC migration and epithelial polarization by controlling the polarity,
CC plasticity, duration and extent of protrusions (Probable).
CC {ECO:0000305|PubMed:30250061}.
CC -!- SUBUNIT: Interacts with RAC1 (GTP-bound form preferentially).
CC {ECO:0000250|UniProtKB:Q9NUQ9}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q9NUQ9}; Lipid-
CC anchor {ECO:0000250|UniProtKB:Q9NUQ9}.
CC -!- SIMILARITY: Belongs to the CYRI family. {ECO:0000305}.
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DR EMBL; AL136704; CAB66639.1; -; mRNA.
DR EMBL; AK055334; BAG51503.1; -; mRNA.
DR EMBL; AK315065; BAG37539.1; -; mRNA.
DR EMBL; CR533504; CAG38535.1; -; mRNA.
DR EMBL; AC104623; AAY24282.1; -; Genomic_DNA.
DR EMBL; CH471053; EAX00879.1; -; Genomic_DNA.
DR EMBL; BC038971; AAH38971.1; -; mRNA.
DR CCDS; CCDS1688.1; -.
DR RefSeq; NP_110424.1; NM_030797.3.
DR RefSeq; XP_005262687.1; XM_005262630.3.
DR RefSeq; XP_006712171.1; XM_006712108.3.
DR AlphaFoldDB; Q9H0Q0; -.
DR SMR; Q9H0Q0; -.
DR BioGRID; 123517; 4.
DR IntAct; Q9H0Q0; 1.
DR STRING; 9606.ENSP00000370724; -.
DR iPTMnet; Q9H0Q0; -.
DR PhosphoSitePlus; Q9H0Q0; -.
DR SwissPalm; Q9H0Q0; -.
DR BioMuta; FAM49A; -.
DR DMDM; 52782791; -.
DR EPD; Q9H0Q0; -.
DR jPOST; Q9H0Q0; -.
DR MassIVE; Q9H0Q0; -.
DR MaxQB; Q9H0Q0; -.
DR PaxDb; Q9H0Q0; -.
DR PeptideAtlas; Q9H0Q0; -.
DR PRIDE; Q9H0Q0; -.
DR ProteomicsDB; 80310; -.
DR Antibodypedia; 55941; 71 antibodies from 14 providers.
DR DNASU; 81553; -.
DR Ensembl; ENST00000381323.7; ENSP00000370724.3; ENSG00000197872.11.
DR Ensembl; ENST00000406434.5; ENSP00000384771.1; ENSG00000197872.11.
DR GeneID; 81553; -.
DR KEGG; hsa:81553; -.
DR MANE-Select; ENST00000381323.7; ENSP00000370724.3; NM_030797.4; NP_110424.1.
DR UCSC; uc002rck.3; human.
DR CTD; 81553; -.
DR DisGeNET; 81553; -.
DR GeneCards; CYRIA; -.
DR HGNC; HGNC:25373; CYRIA.
DR HPA; ENSG00000197872; Low tissue specificity.
DR neXtProt; NX_Q9H0Q0; -.
DR OpenTargets; ENSG00000197872; -.
DR PharmGKB; PA128394730; -.
DR VEuPathDB; HostDB:ENSG00000197872; -.
DR eggNOG; KOG3951; Eukaryota.
DR GeneTree; ENSGT00390000015159; -.
DR HOGENOM; CLU_056470_0_0_1; -.
DR InParanoid; Q9H0Q0; -.
DR OMA; VWNQINA; -.
DR OrthoDB; 1129868at2759; -.
DR PhylomeDB; Q9H0Q0; -.
DR TreeFam; TF314541; -.
DR PathwayCommons; Q9H0Q0; -.
DR SignaLink; Q9H0Q0; -.
DR BioGRID-ORCS; 81553; 13 hits in 1067 CRISPR screens.
DR ChiTaRS; FAM49A; human.
DR GeneWiki; FAM49A; -.
DR GenomeRNAi; 81553; -.
DR Pharos; Q9H0Q0; Tdark.
DR PRO; PR:Q9H0Q0; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q9H0Q0; protein.
DR Bgee; ENSG00000197872; Expressed in cortical plate and 164 other tissues.
DR ExpressionAtlas; Q9H0Q0; baseline and differential.
DR Genevisible; Q9H0Q0; HS.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0030833; P:regulation of actin filament polymerization; IEA:InterPro.
DR InterPro; IPR039789; CYRI.
DR InterPro; IPR009828; CYRIA/CYRIB_Rac1-bd.
DR PANTHER; PTHR12422; PTHR12422; 1.
DR Pfam; PF07159; DUF1394; 1.
PE 2: Evidence at transcript level;
KW Lipoprotein; Membrane; Reference proteome.
FT CHAIN 1..323
FT /note="CYFIP-related Rac1 interactor A"
FT /id="PRO_0000187058"
FT CONFLICT 29
FT /note="E -> D (in Ref. 2; BAG51503)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 323 AA; 37313 MW; 21B0CD613FFD6BD5 CRC64;
MGNLLKVLTR EIENYPHFFL DFENAQPTEG EREIWNQISA VLQDSESILA DLQAYKGAGP
EIRDAIQNPN DIQLQEKAWN AVCPLVVRLK RFYEFSIRLE KALQSLLESL TCPPYTPTQH
LEREQALAKE FAEILHFTLR FDELKMRNPA IQNDFSYYRR TISRNRINNM HLDIENEVNN
EMANRMSLFY AEATPMLKTL SNATMHFVSE NKTLPIENTT DCLSTMTSVC KVMLETPEYR
SRFTSEETLM FCMRVMVGVI ILYDHVHPVG AFCKTSKIDM KGCIKVLKEQ APDSVEGLLN
ALRFTTKHLN DESTSKQIRA MLQ
