ID   CYRIA_MOUSE             Reviewed;         323 AA.
AC   Q8BHZ0;
DT   27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 119.
DE   RecName: Full=CYFIP-related Rac1 interactor A;
GN   Name=Cyria; Synonyms=D12Ertd553e, Fam49a;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Cerebellum;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brain, Brown adipose tissue, Kidney, Lung, and Spleen;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: May negatively regulate RAC1 signaling and RAC1-driven
CC       cytoskeletal remodeling. May regulate chemotaxis, cell migration and
CC       epithelial polarization by controlling the polarity, plasticity,
CC       duration and extent of protrusions. {ECO:0000250|UniProtKB:Q9H0Q0}.
CC   -!- SUBUNIT: Interacts with RAC1 (GTP-bound form preferentially).
CC       {ECO:0000250|UniProtKB:Q9NUQ9}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q9NUQ9}; Lipid-
CC       anchor {ECO:0000250|UniProtKB:Q9NUQ9}.
CC   -!- SIMILARITY: Belongs to the CYRI family. {ECO:0000305}.
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DR   EMBL; AK047142; BAC32969.1; -; mRNA.
DR   EMBL; BC049664; AAH49664.1; -; mRNA.
DR   EMBL; BC052465; AAH52465.1; -; mRNA.
DR   CCDS; CCDS25817.1; -.
DR   RefSeq; NP_001139591.1; NM_001146119.1.
DR   RefSeq; NP_084034.2; NM_029758.4.
DR   RefSeq; XP_006515309.1; XM_006515246.3.
DR   RefSeq; XP_006515310.1; XM_006515247.3.
DR   RefSeq; XP_006515311.1; XM_006515248.3.
DR   AlphaFoldDB; Q8BHZ0; -.
DR   SMR; Q8BHZ0; -.
DR   BioGRID; 218336; 1.
DR   STRING; 10090.ENSMUSP00000065613; -.
DR   iPTMnet; Q8BHZ0; -.
DR   PhosphoSitePlus; Q8BHZ0; -.
DR   EPD; Q8BHZ0; -.
DR   MaxQB; Q8BHZ0; -.
DR   PaxDb; Q8BHZ0; -.
DR   PeptideAtlas; Q8BHZ0; -.
DR   PRIDE; Q8BHZ0; -.
DR   ProteomicsDB; 277026; -.
DR   Antibodypedia; 55941; 71 antibodies from 14 providers.
DR   DNASU; 76820; -.
DR   Ensembl; ENSMUST00000069005; ENSMUSP00000068125; ENSMUSG00000020589.
DR   Ensembl; ENSMUST00000069066; ENSMUSP00000065613; ENSMUSG00000020589.
DR   Ensembl; ENSMUST00000223061; ENSMUSP00000152252; ENSMUSG00000020589.
DR   GeneID; 76820; -.
DR   KEGG; mmu:76820; -.
DR   UCSC; uc007nbc.2; mouse.
DR   CTD; 81553; -.
DR   MGI; MGI:1261783; Cyria.
DR   VEuPathDB; HostDB:ENSMUSG00000020589; -.
DR   eggNOG; KOG3951; Eukaryota.
DR   GeneTree; ENSGT00390000015159; -.
DR   HOGENOM; CLU_056470_0_0_1; -.
DR   InParanoid; Q8BHZ0; -.
DR   OMA; VWNQINA; -.
DR   OrthoDB; 1129868at2759; -.
DR   PhylomeDB; Q8BHZ0; -.
DR   TreeFam; TF314541; -.
DR   BioGRID-ORCS; 76820; 4 hits in 70 CRISPR screens.
DR   ChiTaRS; Fam49a; mouse.
DR   PRO; PR:Q8BHZ0; -.
DR   Proteomes; UP000000589; Chromosome 12.
DR   RNAct; Q8BHZ0; protein.
DR   Bgee; ENSMUSG00000020589; Expressed in embryonic brain and 219 other tissues.
DR   Genevisible; Q8BHZ0; MM.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0030833; P:regulation of actin filament polymerization; IEA:InterPro.
DR   InterPro; IPR039789; CYRI.
DR   InterPro; IPR009828; CYRIA/CYRIB_Rac1-bd.
DR   PANTHER; PTHR12422; PTHR12422; 1.
DR   Pfam; PF07159; DUF1394; 1.
PE   1: Evidence at protein level;
KW   Lipoprotein; Membrane; Reference proteome.
FT   CHAIN           1..323
FT                   /note="CYFIP-related Rac1 interactor A"
FT                   /id="PRO_0000187059"
SQ   SEQUENCE   323 AA;  37343 MW;  21B67A0A4FF23B20 CRC64;
     MGNLLKVLTR EIENYPHFFL DFENAQPTEG EREIWNQISA VLQDSESILT DLQAYKGAGP
     EIRDAIQNPN DIQLQEKAWN AVCPLVVRLK RFYEFSIRLE KALQSLLESL TCPPYTPTQH
     LEREQALAKE FAEILHFTLR FDELKMRNPA IQNDFSYYRR TISRNRINNM HLDIENEVNN
     EMANRMSLFY AEATPMLKTL SNATMHFVSE NKTLPIENTT DCLSTMTSVC KVMLETPEYR
     SRFTSEETLM FCMRVMVGVI ILYDHVHPVG AFCKTSKIDM KGCIKVLKEQ APDSVEGLLN
     ALRFTTKHLN DESTSKQIRA MLQ