ID   CYRIA_PONAB             Reviewed;         323 AA.
AC   Q5R6L2; Q5RD66;
DT   12-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=CYFIP-related Rac1 interactor A;
GN   Name=CYRIA; Synonyms=FAM49A;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May negatively regulate RAC1 signaling and RAC1-driven
CC       cytoskeletal remodeling. May regulate chemotaxis, cell migration and
CC       epithelial polarization by controlling the polarity, plasticity,
CC       duration and extent of protrusions. {ECO:0000250|UniProtKB:Q9H0Q0}.
CC   -!- SUBUNIT: Interacts with RAC1 (GTP-bound form preferentially).
CC       {ECO:0000250|UniProtKB:Q9NUQ9}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q9NUQ9}; Lipid-
CC       anchor {ECO:0000250|UniProtKB:Q9NUQ9}.
CC   -!- SIMILARITY: Belongs to the CYRI family. {ECO:0000305}.
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DR   EMBL; CR858051; CAH90291.1; -; mRNA.
DR   EMBL; CR860476; CAH92598.1; -; mRNA.
DR   RefSeq; NP_001125133.1; NM_001131661.1.
DR   AlphaFoldDB; Q5R6L2; -.
DR   SMR; Q5R6L2; -.
DR   STRING; 9601.ENSPPYP00000014105; -.
DR   Ensembl; ENSPPYT00000014676; ENSPPYP00000014105; ENSPPYG00000012634.
DR   GeneID; 100172018; -.
DR   KEGG; pon:100172018; -.
DR   CTD; 81553; -.
DR   eggNOG; KOG3951; Eukaryota.
DR   GeneTree; ENSGT00390000015159; -.
DR   HOGENOM; CLU_056470_0_0_1; -.
DR   InParanoid; Q5R6L2; -.
DR   OMA; VWNQINA; -.
DR   OrthoDB; 1129868at2759; -.
DR   TreeFam; TF314541; -.
DR   Proteomes; UP000001595; Chromosome 2A.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0030833; P:regulation of actin filament polymerization; IEA:InterPro.
DR   InterPro; IPR039789; CYRI.
DR   InterPro; IPR009828; CYRIA/CYRIB_Rac1-bd.
DR   PANTHER; PTHR12422; PTHR12422; 1.
DR   Pfam; PF07159; DUF1394; 1.
PE   2: Evidence at transcript level;
KW   Lipoprotein; Membrane; Reference proteome.
FT   CHAIN           1..323
FT                   /note="CYFIP-related Rac1 interactor A"
FT                   /id="PRO_0000290015"
FT   CONFLICT        78
FT                   /note="A -> V (in Ref. 1; CAH90291)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        182
FT                   /note="M -> T (in Ref. 1; CAH90291)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        190
FT                   /note="Y -> H (in Ref. 1; CAH90291)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   323 AA;  37313 MW;  21B0CD613FFD6BD5 CRC64;
     MGNLLKVLTR EIENYPHFFL DFENAQPTEG EREIWNQISA VLQDSESILA DLQAYKGAGP
     EIRDAIQNPN DIQLQEKAWN AVCPLVVRLK RFYEFSIRLE KALQSLLESL TCPPYTPTQH
     LEREQALAKE FAEILHFTLR FDELKMRNPA IQNDFSYYRR TISRNRINNM HLDIENEVNN
     EMANRMSLFY AEATPMLKTL SNATMHFVSE NKTLPIENTT DCLSTMTSVC KVMLETPEYR
     SRFTSEETLM FCMRVMVGVI ILYDHVHPVG AFCKTSKIDM KGCIKVLKEQ APDSVEGLLN
     ALRFTTKHLN DESTSKQIRA MLQ